Ifegwu Ibe

Case report: High grade serous fallopian tube carcinoma with rare NRG1 gene fusion presenting as widespread peritoneal carcinomatosis

Anthony Crymes, Mark G. Evans, Tolulope Adeyelu, J. Reid et autres

The discovery of gene fusions involving Neuregulin-1 (NRG1) within solid tumors has important therapeutic implications, as they are being actively explored as targets for emerging ERBB/ERBB2/ERBB3-directed anti-cancer agents. NRG1 fusions are very uncommon across all tumor types and are infrequently documented in …

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Follicular dendritic cell sarcoma involving the parotid gland with expression of the melanocytic marker PRAME

Sumayya Aslam, Ifegwu Ibe, Ying Zhang, Roksolana Demianets et autres

Follicular dendritic cell sarcoma is a rare mesenchymal neoplasm arising from follicular dendritic cells (FDC) of lymphoid follicles. While the majority of FDC sarcoma cases arise within lymph nodes, approximately 30% manifest in extranodal sites. Only 4 prior occurrences of intra-parotid FDC …

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Detection of human papillomavirus (HPV) in malignant melanoma

Adam Bedeir, Hassan Ghani, Cyrus Oster, Anthony Crymes et autres

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Sneaky DCIS-Looking Invasive Ductal Carcinoma of the Breast in the Background of Extensive DCIS

Ifegwu Ibe, Chenchen Niu, Wangpan Shi, Dong Ren

In the most cases, invasive ductal carcinoma (IDC) of the breast is identifiable when they present with classic infiltrative growth pattern. However, subset of IDC can occur in a very sneaky way, significantly mimicking the appearance of ductal carcinoma in situ (DCIS). …

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Detection of Human Papillomavirus (Hpv) in Malignant Melanoma

Adam Bedeir, Hassan Ghani, Cyrus Oster, Anthony Crymes et autres

Increased PD-L1 and p16 Expression are Common in Oropharyngeal Squamous Cell Carcinoma

Anna Shestakova, Jana Tarabay, А. А. Бурцев, Ifegwu Ibe et autres

Overexpression of p16 is closely related to human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (SCC) and pertains a prognostic relevance. Programmed cell death 1-ligand 1 (PD-L1) is another important marker, as anti-PD-L1 immunotherapy is available. Retrospective analysis of 57 cases of the …

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Myelolipoma of renal sinus in a patient with end-stage renal disease: A rare differential diagnosis in renal neoplasms

Ted Farzaneh, Ifegwu Ibe, Sherehan Zada

Myelolipoma is an uncommon benign neoplasm composed of mature adipose tissue and hematopoietic elements. Myelolipoma occurs most frequently in the adrenal gland but occasionally can be seen in extra-adrenal locations such as lung, liver, retroperitoneum, mediastinum, and kidney. We report a case …

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Unusual Left Atrium and Pulmonary Vein Mass: Correlation of Imaging and Immunohistochemical Stains

Behdokht Nowroozizadeh, Ifegwu Ibe, Sara Nowroozizadeh, Thangavijayan Bosemani et autres

Abstract Introduction Intimal sarcoma derived from the pulmonary vein and left atrium is an extremely rare and highly aggressive soft tissue neoplasm. We report a 21-year-old woman with a large filling defect in the pulmonary vein. The lesion extended into the left …

Malignant Biphasic Adenomyoepithelioma: A Rare Entity

Timothy Law, Sonia Veran-Taguibao, Ifegwu Ibe, Wamda Goreal

Abstract Objectives Adenomyoepithelioma of the breast is an uncommon biphasic breast lesion characterized by a cytologically bland epithelial and myoepithelial proliferation. It is often considered benign and thought to represent a variant of intraductal papilloma. However, rare cases of adenomyoepitheliomas have been …

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Multiple renal capillary hemangiomas in a patient with end-stage renal disease

Thanh‐Lan Bui, Justin Glavis‐Bloom, Hanna K. Liu, Alexander Ushinsky et autres

Renal capillary hemangiomas are rare and benign vascular tumors which are typically incidentally discovered on imaging. Surgical excision is often performed, as imaging appearance is similar to malignant lesions. Renal hemangiomas are typically solitary and unilateral. We present a rare case of …

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Sinonasal Extranodal Sinus Histocytosis Mimicking Malignant Sarcomas

Ifegwu Ibe, Behdokht Nowroozizadeh, Xiaohui Zhao, Wamda Goreal et autres

Sinus histocytosis with massive lymphadenopathy, aka Rosai-Dorfman disease (RDD) is a rare, non-hereditary, histiocytic proliferative disorder, usually involving lymph nodes but occasionally occurring in extranodal sites. Extranodal involvement can be seen prior to,concurrently with, or post-nodal disease. We report two cases of …

Sinonasal Extranodal Sinus Histocytosis with Massive Lymphadenopathy Mimicking Malignant Sarcomas

Ifegwu Ibe, Beverly Wang, Wamda Goreal, Xiaohui Zhao et autres

Objectives: Sinus histocytosis with massive lymphadenopathy, aka Rosai-Dorfman disease (RDD) is rare, nonhereditary, benign histiocytic proliferative disorder, usually involving lymph nodes but occasionally occurring in extranodal sites. We report 2 cases where initial mass morphology resembled malignant sarcomas. Immunohistochemistry was useful to …

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