Maria D. Christodoulou

A longitudinal study of avian pox in a small passerine, the Dunnock ( Prunella modularis )

Denise C Wawman, Steven R. Fiddaman, Becki Lawson, Maria D. Christodoulou et autres

Long‐term, longitudinal studies of disease in wild bird populations are rare. Diseases are important determinants of bird survival and may spill‐over into other species including livestock and, in some cases, humans. Avian pox is a globally distributed disease, resulting from infection by …

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Large-scale distribution of cestode infections in wild gentoo penguins and their impact on the host microbiome

Chloe Kaczvinsky, Hila Levy, Stephen Preston, Casey Youngflesh et autres

Intestinal helminths often cause chronic infections, which can impact health and productivity, particularly when combined with other stressors including the environmental challenges faced by polar species. Here we employed a faecal DNA amplicon-sequencing-based approach to study on the epidemiology of tapeworms (Cestoda) …

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ABC_GP_IPM:A Python package for applying GP and ABC to Integral Projection Models, with a Soay sheep case study

Zhixiao Zhu, Maria D. Christodoulou, David Steinsaltz

Abstract The integration of Gaussian Process (GP) models with Approximate Bayesian Com-putation (ABC) has been explored as a flexible framework for constructing Integral Projection Models (IPMs), enabling non-parametric modelling of demographic rela-tionships and the incorporation of population-level information without explicit like-lihoods. However, …

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Relationships between alcohol use and dementia: protocol for an observational study in the UK Clinical Practice Research Datalink

Nasri Fatih, Krishnan Bhaskaran, Klaus P. Ebmeier, Thomas E. Nichols et autres

Abstract Introduction Alcohol consumption is an increasingly recognised modifiable risk factor for dementia, yet whether it has differential impacts on dementia subtypes and its role in disease progression remains unclear. This study aims to: 1) quantify the association between alcohol intake and …

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Improving Joint Estimation of Vital Rates in IPMs via Gaussian Processes and ABC

Maria D. Christodoulou, David Steinsaltz

Abstract Developing population dynamic models that can flexibly adapt to different species remains a challenge due to the context-dependent nature of demographic studies. This work introduces ABC GP IPM, a novel Integral Projection Model (IPM) framework, aimed at mitigating key limitations associated …

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ABC for high-dimensional modular models via MCMC samples

Zhixiao Zhu, Maria D. Christodoulou, David Steinsaltz

Abstract Many complex systems are modelled using modular models , where individual sub-models are estimated separately and then combined. While this simplifies inference, it fails to account for interactions between components. A natural solution is to estimate all components jointly, but this …

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Allometry of cell types in planarians by single-cell transcriptomics

Elena Emili, Alberto Pérez-Posada, Virginia Vanni, David A. Salamanca-Díaz et autres

Allometry explores the relationship between an organism's body size and its various components, offering insights into ecology, physiology, metabolism, and disease. The cell is the basic unit of biological systems, and yet the study of cell-type allometry remains relatively unexplored. Single-cell RNA …

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Does hedge plant choice play a role in rainfall-runoff reduction?

Jordan Bilsborrow, John Adair Barker, Maria D. Christodoulou, Tijana Blanuša

Improved estimates of COVID-19 correlates of protection, antibody decay and vaccine efficacy waning: a joint modelling approach

Daniel J. Phillips, Maria D. Christodoulou, Shuo Feng, Andrew John Pollard et autres

Abstract Reliable estimation of the relationship between COVID-19 antibody levels at the time of exposure and the risk of infection is crucial to inform policy decisions on vaccination regimes. We fit a joint model of anti-spike IgG antibody decay and risk of …

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Allometry of cell types in planarians by single cell transcriptomics

Elena Emili, Alberto Pérez-Posada, Maria D. Christodoulou, Jordi Solana

Abstract Allometry explores the relationship between an organism’s body size and its various components, offering insights into ecology, physiology, metabolism, and disease. The cell is the basic unit of biological systems, and yet, the study of cell type allometry remains relatively unexplored. …

gb (code pays fourni par la source)

Collaborative Platforms and Matchmaking Algorithms for Research and Education, Establishment, and Optimization of Consortia

Eleni Papakonstantinou, Vasiliki Efthymiou, Konstantina Dragoumani, Maria D. Christodoulou et autres

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Comparative plastomics of Amaryllidaceae: inverted repeat expansion and the degradation of the ndh genes in Strumaria truncata Jacq.

Kálmán Könyves, Jordan Bilsborrow, Maria D. Christodoulou, Alastair Culham et autres

Amaryllidaceae is a widespread and distinctive plant family contributing both food and ornamental plants. Here we present an initial survey of plastomes across the family and report on both structural rearrangements and gene losses. Most plastomes in the family are of similar …

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