Accès ouvert
2026
article
OpenAlex
Wanbao Yang, Jeffrey Z. Guo, Jianxun Song, Shaodong Guo
Forkhead box protein O1 (Foxo1) is an insulin-suppressed transcription factor that governs multiple biological processes, including cell proliferation, apoptosis, autophagy, mitochondrial function, and energy metabolism. Over the past 25 years, Foxo1 has evolved from a liner insulin effector to a pleiotropic integrator …
us
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Accès ouvert
2025
article
OpenAlex
Nishtaa Modi, Jeffrey Z. Guo
Epigenetic modifications play a crucial role in gene regulation and have been implicated in various physiological processes and disease conditions. DNA methylation (DNAm) has been implicated in the etiology and progression of many stress-related psychiatric behaviors, such as depression. The ability to …
us
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Accès ouvert
2025
preprint
OpenAlex
Nishtaa Modi, Jeffrey Z. Guo, Ryan C. Lee, Ryan Lee et autres
Epigenetic modifications play a crucial role in gene regulation and have been implicated in various physiological processes and disease conditions. DNA methylation (DNAm) has been implicated in the etiology and progression of many stress-related psychiatric behaviors such as depression. The ability to …
Accès ouvert
2024
article
OpenAlex
Olivia Cox, Fayaz Seifuddin, Jeffrey Z. Guo, Mehdi Pirooznia et autres
Epigenomic annotations for the rat lag far behind those of human and mouse, despite the rat’s immense utility in pharmacological and behavioral studies and the need to understand their epigenetic mechanisms. We have designed a targeted-enrichment method followed by next-generation sequencing (Methyl-Seq) …
us, nl
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2023
book-chapter
OpenAlex
Wanbao Yang, Jeffrey Z. Guo, Shaodong Guo
us
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2023
book-chapter
OpenAlex
Wanbao Yang, Jeffrey Z. Guo, Shaodong Guo
us
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Accès ouvert
2020
article
OpenAlex
David Ezra Gordon, Joseph B Hiatt, Mehdi Bouhaddou, Veronica V. Rezelj et autres
The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a grave threat to public health and the global economy. SARS-CoV-2 is closely related to the more lethal but less transmissible coronaviruses SARS-CoV-1 and Middle East respiratory syndrome coronavirus …
us, fr, de, gb
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Accès ouvert
2020
article
OpenAlex
Mehdi Bouhaddou, Danish Memon, Bjoern Meyer, Kris M. White et autres
us, gb, fr, de
(code pays fourni par la source)
Accès ouvert
2020
article
OpenAlex
David Ezra Gordon, Gwendolyn Μ. Jang, Mehdi Bouhaddou, Jiewei Xu et autres
us, fr, gb
(code pays fourni par la source)
Accès ouvert
2020
preprint
OpenAlex
David Ezra Gordon, Gwendolyn Μ. Jang, Mehdi Bouhaddou, Jiewei Xu et autres
ABSTRACT An outbreak of the novel coronavirus SARS-CoV-2, the causative agent of COVID-19 respiratory disease, has infected over 290,000 people since the end of 2019, killed over 12,000, and caused worldwide social and economic disruption 1,2 . There are currently no antiviral …
us, gb, Afrique du Sud, fr
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Accès ouvert
2020
article
OpenAlex
David Ezra Gordon, Ariane Watson, Assen Roguev, Simin Zheng et autres
us, ie
(code pays fourni par la source)
Accès ouvert
2017
conference-abstract
OpenAlex
Miller Huang, Tina Zheng, Jeffrey Z. Guo, Colin P. Sperring et autres
Neuroblastoma (NB) is a malignant tumor that accounts for ~15% of all pediatric cancer mortality. Nearly half of patients present with high-risk disease that has poor outcome, and the proto-oncogene MYCN is amplified in 45% of high-risk cases. Further, relapsed neuroblastoma demonstrates …
us
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