Fabiana Baroni Alves Makdissi

Assessment of Circulating Tumor DNA as a Risk-Stratification Biomarker in Non-Metastatic Triple-Negative Breast Cancer Undergoing Neoadjuvant Chemotherapy

Rafael Canfield Brianese, Karina Miranda Santiago, Nathália de Angelis de Carvalho, Marina de Brot et autres

All articles of this category (opens in new window) Address for correspondence Dirce Maria Carraro (e-mail: dirce.carraro@accamargo.org.br) Introduction: Patients with triple-negative breast cancer (TNBC) who respond favorably to neoadjuvant chemotherapy (NACT) typically exhibit improved outcomes. In contrast, those with residual disease are …

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BRCA1, HRR Pathway Genes and Ancestry in Triple-Negative Breast Cancer: Insights on Germline Risk and Survival from a Brazilian Cohort Study

Rafael Canfield Brianese, Karina Miranda Santiago, Gabriel Bandeira do Carmo, Leticia Santos Pimentel et autres

All articles of this category (opens in new window) Address for correspondence Dirce Maria Carraro (dirce.carraro@accamargo.org.br) Triple-negative breast cancer (TNBC) is an aggressive and heterogeneous subtype of breast cancer often linked to early onset and African ancestry. A significant proportion of TNBC …

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Inequality of access to breast reconstruction in Brazil: An ecological study.

Bernardo Batista, Aline Chibana, Fabiana Baroni Alves Makdissi, Renato Cagnacci Neto et autres

e13742 Background: Breast reconstruction (BR) is an important step in breast cancer treatment, and several authors have reported disparities in its access across different populations. Brazil has a universal public healthcare system, and 25% of the population has access to a private …

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Functional domain disruption to define the molecular and clinical spectrum of germline RAD51 family variants in hereditary breast cancer (BC).

André Luiz Cicilini, Sandrine Caputo, José Cláudio Casali da Rocha, Solange Moraes Sanches et autres

572 Background: RAD51 paralogs (RAD51C, RAD51D, XRCC2) and RAD50 are crucial in DNA repair. Germline pathogenic variants (PVs) increase hereditary breast/ovarian cancer risk, but domain-specific impacts remain unclear. Methods: Retrospective cohort study (2019-2025) of breast cancer patients undergoing multigene testing. PVs were …

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Central nervous system metastases in hereditary breast cancer according to germline pathogenic variants: A real-world cohort study.

Eduarda Mirela Da Silva Montiel, André Luiz Cicilini, Emily Ribeiro de Moraes Carneiro, Patrick Vinicius Batista de Cerqueira et autres

2035 Background: Hereditary breast cancer (HBC) accounts for approximately 5–10% of cases and involves pathogenic germline variants (PGVs) beyond BRCA1/2 . While metastatic patterns differ by tumor subtype, data on central nervous system (CNS) metastases according to germline genetics remain scarce. We …

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Molecular profiling of male breast cancer in Brazil: Comprehensive genomic characterization of a Latin American cohort.

Elizabeth Santos, Patrick Vinicius Batista de Cerqueira, Fernando Augusto Batista Campos, André Luiz Cicilini et autres

571 Background: Male breast cancer (MBC) is a rare disease, accounting for < 1% of all breast cancers. Current treatment recommendations are largely extrapolated from female breast cancer data, which may not reflect the distinct biological features of MBC. Notably, MBC is …

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Structural determinants compared with genetic ancestry and self-reported race in triple-negative breast cancer disparities: A multilevel analysis in an admixed population.

Patrick Vinicius Batista de Cerqueira, Rafael Canfield Brianese, André Luiz Cicilini, Solange Moraes Sanches et autres

617 Background: Triple-negative breast cancer (TNBC) exhibits marked racial disparities in outcomes. However, the contributions of genetic ancestry, self-reported race, and structural determinants remain unclear, particularly in admixed populations. We aimed to disentangle the independent and combined impact of these factors in …

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Clinical Guidelines from the 2025 International Symposium on Breast Diseases of Inland São Paulo: management of breast cancer in special situations

Eduardo Carvalho Pessoa, Fábio Bagnoli, Marcelo Madeira, Joaquim Teodoro Araujo et autres

Introduction: The 2025 International Symposium on Breast Diseases of Inland São Paulo addressed clinically relevant controversies in the management of breast cancer in special situations, including inflammatory carcinoma, axillary micrometastases after neoadjuvant chemotherapy, early luminal tumors in elderly women, and the use …

Association between Spirituality, Religiosity, and Breast Cancer Treatment

Natália Tomaz Pires, Marina Sonagli, Silvana Soares dos Santos, Cristina Haas Tarabay et autres

Abstract To assess the degree of spirituality and religiosity in patients with breast cancer and its relationship with treatment, the Spiritual/Religious Coping (SRCOPE) scale and World Health Organization's Quality of Life Instrument – Spirituality, Religion and Personal Beliefs Module (WHOQOL-SRPB) questionnaires were …

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425eP Identifying key predictors of pathological complete response to neoadjuvant chemotherapy in hereditary breast cancer: The role of pathogenic moderate-penetrance germline variants

André Luiz Cicilini, José Cláudio Casali da Rocha, Dirce Maria Carraro, Giovana Tardin Torrezan et autres

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447eP Impact of HER2-low status on survival and tumor characteristics in hereditary breast cancer with pathogenic moderate penetrance germline variants

André Luiz Cicilini, José Cláudio Casali da Rocha, Dirce Maria Carraro, Giovana Tardin Torrezan et autres

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Impact of Neoadjuvant Chemotherapy on the Quality of Sexual Life of Women with Breast Cancer

Silvana Soares dos Santos, Solange Moraes Sanches, Maria das Graças Silva Matsubara, Fabiana Baroni Alves Makdissi