Ian Qureshi

604 Magrolimab + docetaxel in previously treated patients with metastatic non-small cell lung cancer (NSCLC)

Oscar Juan-Vidal, Bruno Fang, Luis Paz‐Ares, Ana Laura Ortega Granados et autres

Background Patients with metastatic NSCLC who progress after chemotherapy ± immune checkpoint inhibitors (ICIs) are limited to single-agent chemotherapy (eg, docetaxel). New treatments are needed in this setting. Magrolimab is a cluster of differentiation 47 (CD47)–targeting antibody that blocks antiphagocytic signals on …

es, us, fr (code pays fourni par la source)

Supplementary Figure 1 from Histone Deacetylase Regulation of ATM-Mediated DNA Damage Signaling

K. Ted Thurn, Scott Thomas, Paromita Raha, Ian Qureshi et autres

PDF file, 257K, HDAC inhibitor effect on DNA damage signaling.

Supplementary Figure 4 from Histone Deacetylase Regulation of ATM-Mediated DNA Damage Signaling

K. Ted Thurn, Scott Thomas, Paromita Raha, Ian Qureshi et autres

PDF file, 285K, Proposed Model.

Supplementary Figure 2 from Histone Deacetylase Regulation of ATM-Mediated DNA Damage Signaling

K. Ted Thurn, Scott Thomas, Paromita Raha, Ian Qureshi et autres

PDF file, 254K, Vorinostat induces DNA double strand breaks.

Supplementary Figure 3 from Histone Deacetylase Regulation of ATM-Mediated DNA Damage Signaling

K. Ted Thurn, Scott Thomas, Paromita Raha, Ian Qureshi et autres

PDF file, 206K, HDAC regulation of DNA repair gene expression.

Supplementary Figure 2 from Histone Deacetylase Regulation of ATM-Mediated DNA Damage Signaling

K. Ted Thurn, Scott Thomas, Paromita Raha, Ian Qureshi et autres

PDF file, 254K, Vorinostat induces DNA double strand breaks.

Data from Histone Deacetylase Regulation of ATM-Mediated DNA Damage Signaling

K. Ted Thurn, Scott Thomas, Paromita Raha, Ian Qureshi et autres

Abstract Ataxia–telangiectasia mutated (ATM) is a major regulator of the DNA damage response. ATM promotes the activation of BRCA1, CHK2, and p53 leading to the induction of response genes such as CDKN1A (p21), GADD45A, and RRM2B that promote cell-cycle arrest and DNA …

Data from Histone Deacetylase Regulation of ATM-Mediated DNA Damage Signaling

K. Ted Thurn, Scott Thomas, Paromita Raha, Ian Qureshi et autres

Abstract Ataxia–telangiectasia mutated (ATM) is a major regulator of the DNA damage response. ATM promotes the activation of BRCA1, CHK2, and p53 leading to the induction of response genes such as CDKN1A (p21), GADD45A, and RRM2B that promote cell-cycle arrest and DNA …

Supplementary Figure 1 from Histone Deacetylase Regulation of ATM-Mediated DNA Damage Signaling

K. Ted Thurn, Scott Thomas, Paromita Raha, Ian Qureshi et autres

PDF file, 257K, HDAC inhibitor effect on DNA damage signaling.

Supplementary Figure 4 from Histone Deacetylase Regulation of ATM-Mediated DNA Damage Signaling

K. Ted Thurn, Scott Thomas, Paromita Raha, Ian Qureshi et autres

PDF file, 285K, Proposed Model.

Supplementary Figure 3 from Histone Deacetylase Regulation of ATM-Mediated DNA Damage Signaling

K. Ted Thurn, Scott Thomas, Paromita Raha, Ian Qureshi et autres

PDF file, 206K, HDAC regulation of DNA repair gene expression.

Safety and Efficacy of Lattice Radiotherapy in Voluminous Non-small Cell Lung Cancer

Beatriz E. Amendola, Naipy Pérez, Xiaodong Wu, Marco A. Amendola et autres

Objective Lattice radiotherapy (LRT) is a novel technique of delivering heterogeneous doses of radiation to voluminous tumors not amenable to surgery. Built from the conventional two-dimensional grid, LRT utilizes the power of new technology, three-dimensional radiation allowing the delivery of higher doses …

us (code pays fourni par la source)