Ian P.J. Alwayn

Validation of the Incremental Prognostic Value of Deceased Donation Pre-implantation Kidney Transplant Biopsies through Comprehensive Lesion Quantification with Deep Learning

Ziyang Li, Giorgio Buzzanca, Danny van der Helm, Soufian Meziyerh et autres

Abstract Background Pre-implantation biopsy utility for deceased-donor kidney acceptance is controversial due to processing limitations and interpretive variability. We evaluated whether systematic histological assessment, including expert evaluation and quantification with the BanffNET automated deep learning system (17 lesions), predicts post-transplant failure under …

nl (code pays fourni par la source)

Matrix metalloproteinase 9 associates with post-transplant liver injury despite attenuation by normothermic machine perfusion

Abraham M.P. den Dekker, Jason B. Doppenberg, Maxime J. van Kekem, Sadr ul Shaheed et autres

Matrix metalloproteinase-9 (MMP-9) facilitates leukocyte infiltration during hepatic ischemia-reperfusion injury (IRI), and its inhibition mitigates injury in experimental models, underscoring its therapeutic potential in liver transplantation. Normothermic machine perfusion (NMP) offers a unique opportunity to modulate inflammatory pathways during organ preservation and …

nl, gb (code pays fourni par la source)

Degree of islet function preservation and continuous glucose monitoring in individuals undergoing total pancreatectomy with islet autotransplantation

Maarten C. Tol, Willemijn de Vos, Ian P.J. Alwayn, J. Sven D. Mieog et autres

Abstract Aims/hypothesis In individuals undergoing total pancreatectomy, an additional islet autotransplantation (total pancreatectomy with islet autotransplantation [TPIAT]) can be performed. We investigated the degree to which islet secretory function is preserved after TPIAT and assessed the relation to glycaemic control using continuous …

nl (code pays fourni par la source)

Outcomes of Liver Transplant Versus Partial Hepatectomy for Perihilar Cholangiocarcinoma Patients Requiring Arterial Reconstruction

Edoardo Poletto, Pim B. Olthof, Andrea Ruzzenente, Jean‐Philippe Adam et autres

BACKGROUND AND AIMS: Liver resection (LR) and orthotopic liver transplantation (OLT) are therapeutic options for locally advanced perihilar cholangiocarcinoma (pCCA) requiring hepatic artery reconstruction (HAR). This study aimed to compare short- and long-term outcomes of LR and OLT. Outcomes were major vascular …

it, nl, fr, es, gb, us, de, se (code pays fourni par la source)

Kidneys From Older Donors After Circulatory Death Plus Normothermic Regional Perfusion or Standard Rapid Retrieval Have Comparable Function in the Context of Ex Situ Oxygenated Hypothermic Machine Perfusion

Emma F. van de Geijn, Martin B.A. Heemskerk, Madeleine C. van Dijk, Rutger M. van Rooden et autres

Background. With growing transplant waiting lists, more extended criteria donor organs are being accepted, requiring optimization of the organs to increase utilization. Abdominal normothermic regional perfusion (aNRP) benefits the outcomes of transplanted livers and pancreatic islets, but its effects on donor kidneys …

nl (code pays fourni par la source)

Kidney Transplant Outcomes in Patients with and without Type II Diabetes Mellitus

Jan H.N. Lindeman, Rutger J. Ploeg, Edward J. Sharples, Ian P.J. Alwayn et autres

INTRODUCTION: This study aimed to estimate the impact of type II diabetes (DM-II) on kidney transplant outcomes and graft utility. METHODS: A nationwide, registry-based study compares outcomes for all primary kidney transplantations performed between 2000 and 2022 in the Netherlands in DM-II …

nl, gb, ch (code pays fourni par la source)

Comparing risk-adjusted and unadjusted CUSUM monitoring in Dutch liver procurement quality control: Evaluating the potential in a retrospective setting

Hwai-Ding Lam, Alexander F. Schaapherder, Willemijn N. Nijboer, Andries Erik Braat et autres

Background Risk-adjusted CUSUM outcome monitoring adjusts for risk factors that may influence alarm signaling in heterogeneous datasets. This study aimed to compare risk-adjusted and unadjusted CUSUM graphs for iatrogenic injury and discard rates in liver organ procurement in the Netherlands. Methods Data …

nl (code pays fourni par la source)

Liver transplant outcomes of deceased donor types following normothermic machine perfusion: A meta-analysis

Abraham M.P. den Dekker, Alexander Franssen, Ewout Willem Steyerberg, Hwai-Ding Lam et autres

INTRODUCTION AND OBJECTIVES: Livers from donation after circulatory death (DCD) are less frequently utilized than those from donation after brain death (DBD). Normothermic machine perfusion (NMP) offers the opportunity to assess high-risk grafts before transplantation; however, the predictive value for each respective …

nl (code pays fourni par la source)

Kidney Transplant outcomes in patients with and without type 2 diabetes mellitus

Jan H.N. Lindeman, Rutger J. Ploeg, Edward Sharples, Ian P.J. Alwayn et autres

INTRODUCTION: This study aimed to estimate the impact of type II diabetes (DM-II) on kidney transplant outcomes and graft utility. METHODS: A nationwide, registry-based study compares outcomes for all primary kidney transplantations performed between 2000 and 2022 in the Netherlands in DM-II …

The Value of Chest and Abdominal CT Scans in Deceased Organ Donor Screening: A Prospective Nationwide Cohort Study

Kinita A. Chotkan, Ludo F.M. Beenen, Jacobus W. Mensink, Martin B. A. Heemskerk et autres

Background. Standard computed tomography (CT) scanning in deceased organ donor screening may offer advantages over conventional chest radiograph and abdominal ultrasound. Methods. A nationwide prospective cohort study in the Netherlands was conducted, including all deceased organ donors between July 2022 and April …

nl (code pays fourni par la source)

Predicting metabolic preferences through transcriptomics: a data-driven approach to align metabolic signatures with gene expression profiles

Lente J. S. Lerink, Marleen J de Winter, Jaap Adriaan Bakker, Ian P.J. Alwayn et autres

Complex organisms such as mammals have a sophisticated metabolic network to meet energy demand under varying conditions. This network, which includes the exchange of metabolites between organs, is absent in ex vivo model systems like cell culture or isolated organ perfusion. These …

nl, gb (code pays fourni par la source)

Liver transplantation indications and strategies in polycystic liver disease: A european survey

Renée Duijzer, Ian P.J. Alwayn, Flaminia Ferri, Frederik Nevens et autres

Liver transplantation (LT) remains the only cure for severe polycystic liver disease (PLD). However, LT indications and strategies vary across Europe, resulting in (unwanted) practice variation and unequal access to care for patients with PLD. This study aimed to (1) identify existing …

nl, it, be, de, gr, es, ch, pl, cz, us (code pays fourni par la source)