Accès ouvert
2022
article
OpenAlex
Angela Lehn‐Stefan, Andreas Peter, Jürgen Machann, Fritz Schick et autres
CONTEXT: For a given body mass index (BMI), both impaired metabolic health (MH) and reduced cardiorespiratory fitness (CRF) associate with increased risk of cardiovascular disease (CVD). OBJECTIVE: It remains unknown whether both risk phenotypes relate to CVD independently of each other, and …
de
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Accès ouvert
2021
article
OpenAlex
Róbert Wágner, Martin Heni, Ádám G. Tabák, Jürgen Machann et autres
de, hu, gb, us
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Accès ouvert
2020
article
OpenAlex
Elko Randrianarisoa, Angela Lehn‐Stefan, Anja Hieronimus, Róbert Wágner et autres
Abstract Hyperglycemia and insulin resistance contribute to vascular damage and are regulated by different pathophysiological processes. The aim of the study was to systematically investigate the relative contributions of multiple fasting state- and oral glucose tolerance test (oGTT)-derived glycemic traits to carotid …
de
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Accès ouvert
2020
article
OpenAlex
Angela Lehn‐Stefan, Andreas Peter, Jürgen Machann, Fritz Schick et autres
OBJECTIVE: Elevated plasma glutamate levels are associated with an increased risk of cardiovascular disease (CVD). Because plasma glutamate levels are also strongly associated with visceral adiposity, nonalcoholic fatty liver disease, insulin resistance, and high circulating levels of branched-chain amino acids (BCAAs), it …
de
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Accès ouvert
2020
preprint
OpenAlex
Róbert Wágner, Martin Heni, Ádám G. Tabák, Jürgen Machann et autres
Abstract The state of intermediate hyperglycemia is indicative of elevated risk of developing type 2 diabetes 1 . However, the current definition of prediabetes neither reflects subphenotypes of pathophysiology of type 2 diabetes nor is it predictive of future metabolic trajectories. We …
de, hu, gb, us
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Accès ouvert
2020
article
OpenAlex
Benjamin Assad Jaghutriz, Róbert Wágner, Stephanie Kullmann, Louise Fritsche et autres
Prevalence of both type 1 and type 2 diabetes mellitus is growing worldwide and one major cause for morbidity and mortality. However, not every patient develops diabetes-related complications, but causes for the individual susceptibility are still not fully understood. As a platform …
de
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Accès ouvert
2020
article
OpenAlex
Christoph Hoffmann, Patrick Schneeweiß, Elko Randrianarisoa, G. Schnauder et autres
CONTEXT: Exercise training improves glycemic control and increases mitochondrial content and respiration capacity in skeletal muscle. Rodent studies suggest that training increases mitochondrial respiration in adipose tissue. OBJECTIVE: To assess the effects of endurance training on respiratory capacities of human skeletal muscle …
de
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Accès ouvert
2020
article
OpenAlex
Sebastian Hörber, Angela Lehn‐Stefan, Anja Hieronimus, Sarah Hudak et autres
BACKGROUND: Type 2 diabetes mellitus (T2DM) promotes the development of atherosclerosis and is a major risk factor for cardiovascular disease. High-sensitivity cardiac troponin I (hs-cTnI) assays fundamentally improved the diagnosis of myocardial injury and even enable the prediction of future cardiovascular events …
de
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Accès ouvert
2019
article
OpenAlex
Elko Randrianarisoa, Angela Lehn‐Stefan, Johannes Krier, Anja Böhm et autres
CONTEXT: Adenosine monophosphate (AMP)-activated protein kinase (AMPK) is a heterotrimeric enzyme and central regulator of cellular energy metabolism. The impact of single nucleotide polymorphisms (SNPs) in all 7 AMPK subunit genes on adiposity, glucose metabolism, and lipid metabolism has not yet been …
de
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2019
article
OpenAlex
Elko Randrianarisoa, Angela Lehn‐Stefan, Johannes Krier, Anja Böhm et autres
Abstract Context AMP-activated protein kinase (AMPK) is a heterotrimeric enzyme and central regulator of cellular energy metabolism. The impact of single nucleotide polymorphisms (SNPs) in all seven subunit genes on adiposity, glucose- and lipid metabolism has not been systematically studied yet. Objective …
de
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2019
conference-paper
OpenAlex
R Wagner, Martin Heni, J. Machann, Fritz Schick et autres
Hintergrund: Vor der Entstehung des Typ 2 Diabetes besteht eine längere prädiabetische Übergangsphase, die aktuell aufgrund der Glukosewerte im oralen Glukosetoleranztest (OGTT) klassifiziert wird. Wir stellten die Frage, ob eine neue Klassifikation den Krankheitsverlauf samt Folgeerkrankungen besser vorhersagen könnte, falls weitere Biomarker …
de
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2019
conference-paper
OpenAlex
Christoph Hoffmann, Patrick Schneeweiß, Lisa Kappler, Elko Randrianarisoa et autres
Introduction: Adaptations in skeletal muscle mitochondria are considered to play an important role in the beneficial effect of exercise on metabolic control, while the contribution of adipose tissue is less clear. Methods: 26 obese, sedentary participants (17f/9 m, 30 ± 8years) performed …
de
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