Kyoung-Mi Lee

Changes in lncRNA NORAD expression reflect stiffness-associated phenotypic alterations in human chondrocytes

Kyoung-Mi Lee, Seongyun Choi, Su-Eun Yang, Dong Suk Yoon

kr (code pays fourni par la source)

Control of lipid metabolism in chondrocytes is critical for skeletal growth

Aijaz Ahmad John, Yeon-Suk Yang, Jun Xie, Sachin R. Chaugule et autres

Chondrodysplasia is a genetic disorder characterized by impaired cartilage development and bone growth. Dysregulation of the endoplasmic reticulum (ER) stress is associated with chondrodysplasia. Here, we demonstrate a critical role for the ER stress regulator PPP1R15B in chondrocyte development. PPP1R15B is a …

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Effects of Multiple Metaphyseal Hole Creation on Long Bone Growth in a Rabbit Model

W Kim, Kyeong‐Hyeon Park, Kyoung-Mi Lee, Byoung Kyu Park et autres

PURPOSE: Long bone overgrowth after pediatric skeletal injury or surgery is well recognized, whereas growth suppression without physeal injury is rare. This study aimed to evaluate the effects of creating multiple metaphyseal holes on bone growth and elucidate the underlying mechanisms in …

kr (code pays fourni par la source)

The effect of metaphyseal holes and interposition material on the longitudinal growth stimulation of long bones in a rabbit model

Byoung Kyu Park, Kyoung-Mi Lee, Kyeong‐Hyeon Park, Hoon Park et autres

Aims: It remains unclear which factors influence overgrowth of the tibia, resulting from the metaphyseal hole created during anterior cruciate ligament (ACL) reconstruction in skeletally immature patients. This study aimed to investigate the effects of growth stimulation by creating a metaphyseal hole …

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Downregulation of MicroRNA-495 Alleviates IL-1β Responses among Chondrocytes by Preventing SOX9 Reduction

Soyeong Joung, Dong Suk Yoon, Sehee Cho, Eun Ae Ko et autres

PURPOSE: Our previous work demonstrated that miRNA-495 targets SOX9 to inhibit chondrogenesis of mesenchymal stem cells. In this study, we aimed to investigate whether miRNA-495-mediated SOX9 regulation could be a novel therapeutic target for osteoarthritis (OA) using an in vitro cell culture …

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Enhancement of Mesenchymal Stem Cell-Driven Bone Regeneration by Resveratrol-Mediated SOX2 Regulation

Yoorim Choi, Dong Suk Yoon, Kyoung-Mi Lee, Seong Mi Choi et autres

Mesenchymal stem cells (MSCs) are an attractive cell source for regenerative medicine. However, MSCs age rapidly during long-term ex vivo culture and lose their therapeutic potential before they reach effective cell doses (ECD) for cell therapy. Thus, a prerequisite for effective MSC …

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Inhibition of STAT5A promotes osteogenesis by DLX5 regulation

Kyoung-Mi Lee, Kwang Hwan Park, Ji Suk Hwang, Moses Lee et autres

The regulation of osteogenesis is important for bone formation and fracture healing. Despite advances in understanding the molecular mechanisms of osteogenesis, crucial modulators in this process are not well-characterized. Here we demonstrate that suppression of signal transducer and activator of transcription 5A …

kr, us (code pays fourni par la source)

Inhibition of miR-449a Promotes Cartilage Regeneration and Prevents Progression of Osteoarthritis in In Vivo Rat Models

Dawoon Baek, Kyoung-Mi Lee, Ki Won Park, Jae Wan Suh et autres

Traumatic and degenerative lesions of articular cartilage usually progress to osteoarthritis (OA), a leading cause of disability in humans. MicroRNAs (miRNAs) can regulate the differentiation of human bone marrow-derived mesenchymal stem cells (hBMSCs) and play important roles in the expression of genes …

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Enhanced articular cartilage regeneration with SIRT1-activated MSCs using gelatin-based hydrogel

Seong Mi Choi, Kyoung-Mi Lee, Seung Bae Ryu, Yoo Jung Park et autres

To investigate the functional effects of resveratrol (RSV) on mesenchymal stem cells (MSCs), we treated MSCs with RSV continuously during ex vivo expansion. MSCs were continuously treated with RSV from passage (P) 0 to P5. A proliferative capacity of RSV-treated MSCs was …

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Zinc Promotes Osteoblast Differentiation in Human Mesenchymal Stem Cells Via Activation of the cAMP-PKA-CREB Signaling Pathway

Kwang Hwan Park, Yoorim Choi, Dong Suk Yoon, Kyoung-Mi Lee et autres

The crucial trace element zinc stimulates osteogenesis in vitro and in vivo. However, the pathways mediating these effects remain poorly understood. This study aimed to investigate the effects of zinc on osteoblast differentiation in human bone marrow-derived mesenchymal stem cells (hBMSCs) and …

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Direct Control of Stem Cell Behavior Using Biomaterials and Genetic Factors

Jeong‐Kee Yoon, Mi-Lan Kang, Joo Hyun Park, Kyoung-Mi Lee et autres

Stem cells have recently emerged as an important candidate for cell therapy. However, some major limitations still exist such as a small quantity of cell supply, senescence, and insufficient differentiation efficiency. Therefore, there is an unmet need to control stem cell behavior …

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Effects of structurally stabilized EGF and bFGF on wound healing in type I and type II diabetic mice

Seong Mi Choi, Kyoung-Mi Lee, Hyun Jung Kim, Ik Kyu Park et autres

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