Hao Luo

Design of optimized epigenetic regulators for durable gene silencing with application to PCSK9 in nonhuman primates

Shaoshuai Mao, Wenbo Peng, Zhengyan Feng, Yangchao Chen et autres

cn (code pays fourni par la source)

Systematic design and evaluation of artificial CO2 assimilation pathways

Guangyun Chu, Hao Luo, Zhitao Mao, Yufeng Mao et autres

With the advancement of industry and bio-agriculture, the effective management of CO 2 has emerged as a critical challenge for humanity. This study systematically explores multiple CO 2 assimilation pathways using the comb-FBA algorithm, aiming to identify efficient artificial carbon fixation pathways. …

cn (code pays fourni par la source)

A single helicase-binding domain of DnaG couples with hexameric helicase DnaB in Bacillus stearothermophilus

Hao Luo, Yingqin Zhou, Zhongchuan Liu, Yuyang Qin et autres

In bacterial DNA replication, helicase DnaB and primase DnaG form the primosome. Helicase DnaB unwinds double-stranded DNA (dsDNA) to provide templates for DNA polymerase, whereas primase DnaG supplies RNA primers to DNA polymerase for the synthesis of Okazaki fragments. How primase DnaG …

cn (code pays fourni par la source)

BVT-IMA: Binary Vision Transformer with Information-Modified Attention

Zhenyu Wang, Hao Luo, Xuemei Xie, Fan Wang et autres

As a compression method that can significantly reduce the cost of calculations and memories, model binarization has been extensively studied in convolutional neural networks. However, the recently popular vision transformer models pose new challenges to such a technique, in which the binarized …

cn, ky (code pays fourni par la source)

CL2CM: Improving Cross-Lingual Cross-Modal Retrieval via Cross-Lingual Knowledge Transfer

Yabing Wang, Fan Wang, Jianfeng Dong, Hao Luo

Cross-lingual cross-modal retrieval has garnered increasing attention recently, which aims to achieve the alignment between vision and target language (V-T) without using any annotated V-T data pairs. Current methods employ machine translation (MT) to construct pseudo-parallel data pairs, which are then used …

ky, cn (code pays fourni par la source)

Architecture and Future Development Direction of Urban Energy Internet

Gang Wu, Yunce Su, Siying Du, Ruiguang Ma et autres

Urban energy internet can achieve a deep integration and interaction of power network, natural gas network, electrified transportation network and other networks, which is the direction of transformation and development of urban energy system in the future. Firstly, this paper gives the …

Flux regulation through glycolysis and respiration is balanced by inositol pyrophosphates in yeast

Ning Qin, Lingyun Li, Xu Ji, Rui Pereira et autres

Although many prokaryotes have glycolysis alternatives, it's considered as the only energy-generating glucose catabolic pathway in eukaryotes. Here, we managed to create a hybrid-glycolysis yeast. Subsequently, we identified an inositol pyrophosphatase encoded by OCA5 that could regulate glycolysis and respiration by adjusting …

se, cn, fi, de, dk (code pays fourni par la source)

Physicochemical and Photocatalytic Properties of 3D-Printed TiO2/Chitin/Cellulose Composite with Ordered Porous Structures

Lei Li, Jingdan Li, Hao Luo, Shengjuan Li et autres

In this study, we printed three-dimensional (3D) titanium dioxide (TiO2)/chitin/cellulose composite photocatalysts with ordered interconnected porous structures. Chitin microparticles were mixed with cellulose in the N-methylmorpholine-N-oxide (NMMO) solution to prepare the printing “ink”. TiO2 nanoparticles were embedded on the chitin/cellulose composite in …

cn (code pays fourni par la source)

A Comparative Analysis of Bike-Sharing and E-Scooter Sharing Services in a College Town

Ricardo Chahine, Hao Luo, Hua Cai, Konstantina Gkritza

us (code pays fourni par la source)

Oxidative Catalytic Fractionation of Lignocellulosic Biomass under Non-alkaline Conditions

Hao Luo, Eric P. Weeda, Manar Alherech, Colin W. Anson et autres

Biomass pretreatment methods are commonly used to isolate carbohydrates from biomass, but they often lead to modification, degradation, and/or low yields of lignin. Catalytic fractionation approaches provide a possible solution to these challenges by separating the polymeric sugar and lignin fractions in …

us (code pays fourni par la source)

Microbial Synthesis of Human-Hormone Melatonin at Gram Scales

Hao Luo, Konstantin Schneider, Ulla Christensen, Lei Yang et autres

Abstract Melatonin is a commercially attractive tryptophan-derived hormone. Here we describe a bioprocess for the production of melatonin using Escherichia coli to high titers. The first engineered strain produced 0.13 g/L of melatonin from tryptophan under fed-batch fermentation conditions. A 4-fold improvement …

dk, us (code pays fourni par la source)

Directed Metabolic Pathway Evolution Enables Functional Pterin-Dependent Aromatic-Amino-Acid Hydroxylation in Escherichia coli

Hao Luo, Lei Yang, Se Hyeuk Kim, Tune Wulff et autres

Tetrahydrobiopterin-dependent hydroxylation of aromatic amino acids is the first step in the biosynthesis of many neuroactive compounds in humans. A fundamental challenge in building these pathways in Escherichia coli is the provision of the non-native hydroxylase cofactor, tetrahydrobiopterin. To solve this, we …

dk, us (code pays fourni par la source)