Xiaoliang Xie

Integrated network toxicology and experimental validation to investigate potential mechanisms associated with aspartame-induced malignant phenotypic changes in colorectal cancer

Quanxia Liu, Yu Dong, Lijiao Qiao, Nan Wang et autres

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Association analysis of the differences in intestinal flora and clinical tumor indicators among colorectal cancer patients

Lan Ma, Wenjing Wang, shihu Ma, Yanbai Wang et autres

Background Colorectal cancer (CRC) is the third most common malignant tumor globally, and its development is closely related to intestinal flora dysbiosis. However, the heterogeneity of cancerous tissues, paracancerous tissues, and fecal flora, and their clinical significance, has not been fully elucidated. …

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Study on the Effect of Antibiotics on the Efficacy of PD-1 Inhibitors and Its Regulatory Mechanism via the Intestinal Bacterial Community

Xuebing Zhou, Liyuan Liu, Xue Wang, Dan Jiang et autres

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Network pharmacology-based mechanism analysis of dauricine on the alleviating Aβ-induced neurotoxicity in Caenorhabditis elegans

Ranran Zhang, Xiaoyan Huang, Chunling Zhou, Qian Zhang et autres

BACKGROUND: Dauricine (DAU), a benzyl tetrahydroisoquinoline alkaloid isolated from the root of Menispermum dauricum DC, exhibits promising anti-Alzheimer's disease (AD) effects, but its underlying mechanisms remain inadequately investigated. This paper aims to identify potential targets and molecular mechanisms of DAU in AD …

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Metabolome analysis of genus Forsythia related constituents in Forsythia suspensa leaves and fruits using UPLC-ESI-QQQ-MS/MS technique

Lingdi Liu, Yu Sun, Chunxiu Wen, Tao Jiang et autres

Forsythia suspensa is a traditional Chinese herb. Its numerous metabolites have important roles, as they possessed a wide range of biological activities. This study explored the accumulations of F. suspensa metabolites by performing widely targeted metabolomic analysis. The metabolites were studied at …

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Potential and functional prediction of six circular RNAs as diagnostic markers for colorectal cancer

Liyuan Liu, Dan Jiang, Yuliang Qu, Hongxia Wang et autres

Background: Circular RNAs (circRNAs) have been discovered in colorectal cancer (CRC), but there are few reports on the expression distribution and functional mining analysis of circRNAs. Methods: Differentially expressed circRNAs in CRC tissues and adjacent normal tissues were screened and identified by …

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Metabolomics Analysis of Metabolites in Forsythia suspense Fruit Using UPLC/ESI-Q TRAP-MS/MS

Lingdi Liu, Chunxiu Wen, Wei Tian, Xiaoliang Xie et autres

Forsythiae Fructus, the fruit of Forsythia suspense is a traditional Chinese hebal medicine that has the antiviral and antioxidant effects in China. Modern analytical chemistry studies showed that the extracts of Forsythiae Fructus contain many bioactive components, such as flavonoids, lignans, phenolic …

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SNP Molecular Markers Development and Genetic Diversity Analysis of Forsythia suspensa Based on SLAF-seq Technology

Tao Jiang, Chunxiu Wen, Wei Tian, Xiaoliang Xie et autres

Forsythia suspensa (Thunb.) Vahl is an important medicinal plant that has great value to study in China. In this study, the 39 Forsythia suspensa materials were used specific loci amplified fragment sequencing technology (SLAF-seq) to develop SNP molecular markers. A total of …

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Integrated Data Reveal The Flavonoid Biosynthesis Metabolic Pathway In Semen Ziziphi Spinosae Using Transcriptomic And Metabolomic

Tao Jiang, Lingdi Liu, Chunxiu Wen, Xiaoliang Xie et autres

Abstract Semen Ziziphi Spinosae (SZS) is used to treat neurasthenia, insomnia, and anxiety in China. The extract from SZS contains many bioactive components, such as flavonoids, alkaloids, and terpenoids. Among these, the flavonoids are the main bioactive compounds that have been proven …

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CircRNA-miRNA-mRNA Regulatory Network in Colorectal Cancer

Liyuan Liu, Shan Wu, Dan Jiang, Yuliang Qu et autres

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Metabolomics Analysis of Metabolites at Two Different Types of Forsythiae Fructus Using UPLC/ESI-Q TRAP-MS/MS

Lingdi Liu, Chunxiu Wen, Xiaoliang Xie, Wei Tian et autres

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Establishment of a Colorectal Cancer-Related MicroRNA-mRNA Regulatory Network by Microarray and Bioinformatics

Dan Jiang, Xiaoliang Xie, Zhenhui Lu, Liyuan Liu et autres

Colorectal cancer (CRC) is one of the most malignant cancers with high morbidity and mortality. MicroRNAs (miRNAs) are small non-coding RNAs that affect biological processes by binding to mRNAs and regulating their expression, and epigenetic alterations including miRNA dysregulation are significantly involved …

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