Accès ouvert
2026
article
OpenAlex
Georgios Boutsikas, Konstantinos Agiannitopoulos, Elisavet Kouvidi, Myrto Katraki et autres
BACKGROUND: Flow cytometry and real-time quantitative polymerase chain reaction (qRT-PCR) for MYD88 mutations (MYD88mt) are routinely performed on bone marrow aspirates during the diagnostic evaluation of IgM monoclonal paraproteinemia. The potential predictive value of immunophenotypic findings for molecular results, however, remains to …
gr
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Accès ouvert
2026
article
OpenAlex
Georgios Boutsikas, Konstantinos Agiannitopoulos, Ioannis Anagnostopoulos, Myrofora Vikentiou et autres
Flow cytometry is an essential diagnostic method in hematology, and one of its main applications is the assessment of the clonality of mature B cells. We present a case report of a patient referred for the investigation of absolute lymphocytosis. The flow …
gr, ch
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Accès ouvert
2026
article
OpenAlex
Konstantinos Agiannitopoulos, Charoula Achilla, Emmanouela Poupounaki, Parthena Meltzanidou et autres
The data that support the findings of this study are available from the corresponding author upon reasonable request.
gr
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Accès ouvert
2026
article
OpenAlex
Anastasios Papageorgiou, Fragkiski-Ioanna Sofiou, ANASTASSIOS PHILIPPOU, Maria Gkrampovari et autres
The role of proteins in cellular activity has received close attention. Proteome analysis can detect early enough changes in the cell before the appearance of pathological changes. Due to the increasing number of cardiovascular complications, more specifically hypertension in modern life, this …
gr, bg
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Accès ouvert
2026
article
OpenAlex
Konstantinos Agiannitopoulos, Anastasios Papageorgiou, Elisavet Kouvidi, Eleni Kalampoka et autres
Cardiovascular diseases (CVDs) are the foremost contributor to global mortality, with a significant inherited factor that has long been recognized but only recently become decipherable. Next-generation sequencing (NGS) has transformed the study of cardiovascular genetics, allowing researchers to move beyond single-gene analyses …
gr, bg
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Accès ouvert
2025
article
OpenAlex
Konstantinos Agiannitopoulos, Elisavet Kouvidi
Leukemia is a heterogeneous group of hematologic malignancies characterized by the dysfunctional proliferation of white blood cells in the bone marrow. Genetic alterations are important risk factors for the development and progression of leukemia, and their detection is crucial. Although many genetic …
gr, us
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Accès ouvert
2024
article
OpenAlex
Nikolaos Tsoulos, Konstantinos Agiannitopoulos, Kevisa Potska, Anastasia Katseli et autres
BACKGROUND/AIM: The application of next-generation sequencing (NGS) technology in the genetic investigation of hereditary cancer is important for clinical surveillance, therapeutic approach, and reducing the risk of developing new malignancies. The aim of the study was to explore genetic predisposition in individuals …
gr, ro, tr, cy, lv
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Accès ouvert
2024
article
OpenAlex
Nikolaos Tsoulos, Eirini Papadopoulou, Konstantinos Agiannitopoulos, Dimitrios Grigoriadis et autres
Breast cancer (BC) is the most prominent tumor type among women, accounting for 32% of newly diagnosed cancer cases. BC risk factors include inherited germline pathogenic gene variants and family history of disease. However, the etiology of the disease remains occult in …
gr
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Accès ouvert
2024
preprint
OpenAlex
Kevisa Potska, Anastasia Katseli, Konstantinos Agiannitopoulos, CHRISTINA NTOGKA et autres
Pancreatic cancer stands out as one of the most lethal forms of malignancies, representing 2% of all cancer cases and contributing to 5% of cancer-related fatalities. Therefore, early detection of pancreatic cancer is crucial for enhancing treatment outcomes. Various hereditary cancer syndromes …
gr, ro, tr, gb
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Accès ouvert
2024
article
OpenAlex
Eirini Papadopoulou, George Rigas, Elena Fountzilas, Anastasios L. Boutis et autres
PURPOSE The pan-cancer presence of microsatellite instability (MSI)–positive tumors demonstrates its clinical utility as an agnostic biomarker for identifying immunotherapy-eligible patients. Additionally, MSI is a hallmark of Lynch syndrome (LS), the most prevalent cancer susceptibility syndrome among patients with colorectal and endometrial …
gr
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Accès ouvert
2024
article
OpenAlex
Christos J. Markopoulos, Nikolaos Tsoulos, Konstantinos Agiannitopoulos, Evangelia Karagianni
BACKGROUND/AIM: Breast cancer remains the most prevalent type of cancer among women worldwide, and it remains the primary cause of cancer-related deaths in this demographic. Neuroendocrine breast cancer (NBC), an uncommon subtype comprising less than 1% of cases, typically occurs in older …
gr
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Accès ouvert
2024
article
OpenAlex
Konstantinos Agiannitopoulos, Anastasia Katseli, Kevisa Potska, CHRISTINA NTOGKA et autres
BACKGROUND/AIM: Gliomas are highly heterogeneous malignancies originating from diverse cell types within the brain. Although their precise etiology is frequently unknown, risk factors, such as chemical exposure, radiation, and specific uncommon genetic disorders have been identified. Diagnosis typically entails imaging tests, such …
gr
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