Ian A. Myles

Emerging microbiome-based therapies for atopic dermatitis: clinical insights and future development

Kingsley Osei-Karikari, Kyle Jones, Anna Erickson, Ian A. Myles

INTRODUCTION: overgrowth. However, given the emerging understanding of microbiome-mediated and environmentally driven disease mechanisms, expanding therapeutic strategies to include dysbiosis and upstream environmental contributors represents a promising direction for future research. AREAS COVERED: This manuscript will review the strengths and limitations of …

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“Yet the Problem Remains”: Why Genetic Determinism Still Haunts Biomedical Research

Christopher Donohue, Ian A. Myles

After the horrors of the Holocaust and its connections to eugenics were revealed to the world, many post-war population geneticists sought to establish rhetorical distance from the Nazi's state-led campaigns, without abandoning their belief that actively shaping the population's genetics would produce …

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Topical steroid withdrawal: dissecting the controversy

Ian A. Myles, Grace Ratley

In the past few years, topical steroid withdrawal (TSW) has received increasing recognition from research and regulatory agencies. Delphi protocols have solidified the clinical features and treatment options recognized by clinicians. Pilot studies elucidating the mechanisms of TSW pathology have been performed. …

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P.A.D.D.L.E.: a hypothesis generation tool for assessing pollution’s potential role in disease

Grace Ratley, Aditi I Vijendra, Jalin Jordan, Pranav Thota et autres

Since the 1960s, tens of thousands of chemicals have been added to the global market, yet the vast majority lack comprehensive health risk assessments. During this same period, industrialized nations have experienced dramatic increases in inflammatory diseases, raising concerns about environmental contributors. …

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Examining the Unanswered Questions in TSW: A Case Series of 16 Patients and Review of the Literature

Max Yang Lu, Anna Erickson, Aditi I Vijendra, Grace Ratley et autres

Background/Objectives: Topical steroid withdrawal syndrome is an underrecognized (and at times controversial) diagnosis, predominantly seen in individuals with a history of prolonged medium- to high-potency steroid use with sudden cessation. We aim to present topical steroid withdrawal clinical cases along with a …

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Molecular connections between inflammation and social determinants of health

Claire M. Kunkle, Jalin Jordan, Anna Erickson, Kingsley Osei-Karikari et autres

Chronic inflammatory diseases such as autoimmune disorders, cancer, cardiovascular diseases and neurodegenerative disorders are a significant cause of morbidity and mortality in the industrialized world. Socioeconomically disadvantaged communities bear a disproportionately high burden of these inflammatory diseases. This review synthesizes evidence linking …

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Biomarkers Are Consistent With Patient‐Reported Allergic Sensitization in Topical Steroid Withdrawal

Nadia Shobnam, Jalin Jordan, Pranav Thota, Ian A. Myles

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61872 The role of nicotinic acid and mitochondrial function in the pathogenesis of topical steroid withdrawal

Sarini Saksena, Nadia Shobnam, Grace Ratley, Manoj Yadav et autres

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Possible Treatment of Topical Steroid Withdrawal with Methylene Blue Case Report: Implications for Mitochondrial Pathology

Jalin Jordan, Simon Rose-Ward, Kingsley Osei-Karikari, Ian A. Myles

Introduction: Recent observations have demonstrated that topical steroid withdrawal (TSW) is an induced, but targetable, defect in mitochondrial complex I function that warrants further investigation. Case Presentation: An 8-year-old girl with atopic dermatitis (AD) was treated with topical corticosteroids (TCSs), including high-potency …

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Targeting Pollutants in the Treatment and Prevention of Atopic Dermatitis

Nadia Shobnam, Ian A. Myles

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0172 Environmental pollutants and atopic dermatitis: Associations across age groups in a cross-sectional analysis

J. Jordan, Grace Ratley, Adithya Reddy Vijendra, Ian A. Myles

Reply to Brown and Burleigh’s “Molecular and Cellular Mechanisms Leading to Topical Steroid Withdrawal Syndrome Remain Unexplained and Warrant Further Research”

Nadia Shobnam, Grace Ratley, Sarini Saksena, Manoj Yadav et autres

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