Isabel de Fátima Correia Batista

cAmbly, a peptide derived from the star tick Amblyomma sculptum salivary gland transcriptome, attenuates inflammatory pain by activating endogenous opioid pathways

Michelle Cristiane Búfalo, Jorge Luiz Dallazen, Barbara Behr Martins, Gessica Sabrina de Assis Silva et autres

Pain affects more than 1.5 billion people worldwide and remains a leading cause of disability, but currently available analgesics often have limited efficacy and significant adverse effects. In this context, bioactive molecules derived from animal venoms and secretions have emerged as promising …

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E se uma cobra picar? Tem o soro para tratar!: una obra que conecta literatura infantil y juvenil, ciencia y educación no formal

Isabel de Fátima Correia Batista

El Instituto Butantan, ubicado en São Paulo (Brasil), además de ser una referencia histórica, científica y tecnológica, también actúa en la promoción de la cultura y el ocio. Una investigación reciente reveló que los jóvenes brasileños admiran a los científicos, pero indicó …

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E se uma cobra picar? Tem o soro para tratar!: obra que conecta literatura infantojuvenil, ciência e educação não formal

Isabel de Fátima Correia Batista

The Butantan Institute, located in São Paulo, Brazil, is not only a historical, scientific, and technological reference institution but also actively promotes culture and leisure. A recent study revealed that Brazilian youth admire scientists; however, it also indicated that they feel intimidated …

Transcriptomic Dissection of Bothrops moojeni Venom Reveals Fraction-Specific Modulation of Host Cellular Pathways

Fernanda D’Ámelio, Rodrigo Pinheiros Araldi, Isabel de Fátima Correia Batista, Álvaro Rossan de Brandão Prieto da Silva et autres

Snake venom is a remarkably complex cocktail of bioactive molecules capable of hijacking diverse host physiological processes, yet how individual venom components drive these cellular responses remains a bit of a black box. To map these dynamics, we ran a comparative transcriptomic …

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A Novel Ocellatin-P1 Isoform from Leptodactylus labyrinthicus Frog Skin Secretion: Purification, Biological Properties and Three-Dimensional Structure

César Augusto Prías-Márquez, E.S.F. Alves, Carlos José Correia de Santana, Osmindo Rodrigues Pires Júnior et autres

A novel ocellatin-P1 isoform was isolated and purified from the skin secretion of the pepper frog Leptodactylus labyrinthicus. The crude skin secretion was fractionated by reversed-phase high-performance liquid chromatography (RP-HPLC) using a C8 column and the peptide was subsequently purified on a …

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Anti-Inflammatory and Antinociceptive Potential of Vespa crabro Venom Identified Through Human Joint Tissue In Vitro Screening Platform

Douglas S. Oliveira, Nancy Starobinas, Michelle Cristiane Búfalo, Hugo Vigerelli et autres

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Biodiversity-Driven Screening of Amphibian Skin Secretions for Inflammatory Modulation in Joint Diseases

Douglas Souza Oliveira, César Alexandre, Miryam Paola Alvarez Flores, Isadora Maria Villas-Boas et autres

This study explores the direct effects of amphibian skin secretions on human cells involved in joint diseases, aiming to identify species with potential for inflammatory modulation. Secretions were obtained from sixteen species distributed across Brazilian biomes and one European species. Following biochemical …

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Comprehensive RNA-Seq Analysis of Human Osteoclast Function in Response to Bothrops moojeni Venom Fractions: Pathways of Bone Resorption and Cytoskeletal Disruption

Fernanda D’Ámelio, Hugo Vigerelli, Rodrigo Pinheiro Araldi, Isabel de Fátima Correia Batista et autres

This study investigated the effects of Bothrops moojeni (B. moojeni) venom and its high- (HMM) and low-molecular mass (LMM) fractions on human osteoclast (OC) differentiation and function in vitro, aiming to identify novel therapeutics for bone disorders. Venom preparations were applied at …

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The development of a micro method that optimizes venom fractionation for proteomic analysis

MARCOS VINICIUS BURI, Hugo Vigerelli, R. Marques-Porto, A.M. Chudzinski-Tavassi et autres

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Snake and arthropod venoms: Search for inflammatory activity in human cells involved in joint diseases

Miryam Paola Alvarez Flores, Isabel de Fátima Correia Batista, Isadora Maria Villas-Boas, Michelle Cristiane Búfalo et autres

Most anti-inflammatory drugs currently adopted to treat chronic inflammatory joint diseases can alleviate symptoms but they do not lead to remission. Therefore, new and more efficient drugs are needed to block the course of joint inflammatory diseases. Animal venoms, rich in bioactive …

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Plant Kunitz Inhibitors and Their Interaction with Proteases: Current and Potential Pharmacological Targets

Camila Ramalho Bonturi, Ana Beatriz da Silva Teixeira, Vitória Morais Rocha, Penélope Ferreira Valente et autres

The action of proteases can be controlled by several mechanisms, including regulation through gene expression; post-translational modifications, such as glycosylation; zymogen activation; targeting specific compartments, such as lysosomes and mitochondria; and blocking proteolysis using endogenous inhibitors. Protease inhibitors are important molecules to …

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The phytoactive constituents of Eugenia selloi B.D. Jacks (pitangatuba): Toxicity and elucidation of their anti-inflammatory mechanism(s) of action

Josy Goldoni Lazarini, Adna Prado Massarioli, Jackeline Cintra Soares, Bruno Dias Nani et autres

proved to be a promising, yet underexplored source of bioactive compounds, which can be useful employed in agribusiness and in the pharmaceutical and food industry to develop new products or human health supplies.

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