Sultan Khetani

A Programmable, 3D Neuron‐On‐Chip Platform Integrating Near Real‐Time Biosensing and Multiaxial Loading for Mechanobiological Injury Profiling

Sultan Khetani, Kar Wey Yong, Mawafag F. Alhasadi, Amir Hamedzadeh et autres

Mechanical forces imparted to the central nervous system (CNS) generate complex, load-dependent injury patterns, yet the molecular mechanisms linking physical insult to biomarker response remain poorly defined. Here, the Neuron-Injury-on-a-Chip (NIOC) platform is presented as a programmable 3D microfluidic system integrating multiaxial …

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Nanoporous Carbon Immunosensor for Highly Accurate and Sensitive Clinical Detection of Glial Fibrillary Acidic Protein in Traumatic Brain Injury, Stroke, and Spinal Cord Injury

Sultan Khetani, Razieh Salahandish, Jason Tabor, Matthew J. Chilvers et autres

Elevated glial fibrillary acidic protein (GFAP) in the blood serum is one of the promising bodily fluid markers for the diagnosis of central nervous system (CNS) injuries, including traumatic brain injury (TBI), stroke, and spinal cord injury (SCI). However, accurate and point-of-care …

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CoVSense: Ultrasensitive Nucleocapsid Antigen Immunosensor for Rapid Clinical Detection of Wildtype and Variant SARS‐CoV‐2

Razieh Salahandish, Jae Eun Hyun, Fatemeh Haghayegh, Hamed Osouli Tabrizi et autres

The widespread accessibility of commercial/clinically-viable electrochemical diagnostic systems for rapid quantification of viral proteins demands translational/preclinical investigations. Here, Covid-Sense (CoVSense) antigen testing platform; an all-in-one electrochemical nano-immunosensor for sample-to-result, self-validated, and accurate quantification of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

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Immuno-affinity Potent Strip with Pre-Embedded Intermixed PEDOT:PSS Conductive Polymers and Graphene Nanosheets for Bio-Ready Electrochemical Biosensing of Central Nervous System Injury Biomarkers

Razieh Salahandish, Fatemeh Haghayegh, Sultan Khetani, Mohsen Hassani et autres

Future point-of-care (PoC) and wearable electrochemical biosensors explore new technology solutions to eliminate the need for multistep electrode modification and functionalization, overcome the limited reproducibility, and automate the sensing steps. In this work, a new screen-printed immuno-biosensor strip is engineered and characterized …

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(Invited) Heterogeneous Surface Energy Maps of Differentiated-Cath-a Cancer Cells Revealed Via Transitional Tapping Atomic Force Microscopy (TT-AFM)

Arindam Phani, Sultan Khetani, Amir Sanati‐Nezhad, Seonghwan Kim

μDrop: Multi-analyte portable electrochemical-sensing device for blood-based detection of cleaved tau and neuron filament light in traumatic brain injury patients

Sultan Khetani, Anupriya Singh, Brendon C. Besler, Savitri Butterworth et autres

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UV-triggered polymerization of polycatecholamines enables the production of organ-on-chips inside a biosafety cabinet

Sultan Khetani, Kar Wey Yong, Kevin Guan, Anupriya Singh et autres

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Engineering Shelf-Stable Coating for Microfluidic Organ-on-a-Chip Using Bioinspired Catecholamine Polymers

Sultan Khetani, Kar Wey Yong, Vinayaraj Ozhukil Kollath, Erin Eastick et autres

The conceptualization of body-on-a-chip in 2004 resulted in a new approach for studying human physiology in three-dimensional culture. Despite pioneering works and the progress made in replicating human physiology on-a-chip, the stability, reliability, and preservation of cell-culture-treated microfluidic chips remain a challenge. …

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Single-step functionalization of poly-catecholamine nanofilms for ultra-sensitive immunosensing of ubiquitin carboxyl terminal hydrolase-L1 (UCHL-1) in spinal cord injury

Sultan Khetani, Vinayaraj Ozhukil Kollath, Erin Eastick, Chantel T. Debert et autres

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Reproducible and Scalable Generation of Multilayer Nanocomposite Constructs for Ultrasensitive Nanobiosensing

Razieh Salahandish, Hossein Zargartalebi, Mohsen Janmaleki, Sultan Khetani et autres

Abstract Electrochemical nanobiosensors are ultrasensitive tools used for detection and monitoring of various markers in biofluids. In the absence of reliable techniques for large‐scale production of reproducible nanomaterial structures on the electrodes, they are created individually in batch‐production. This has become a …

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Filter‐based isolation, enrichment, and characterization of circulating tumor cells

Sultan Khetani, Mehdi Mohammadi, Amir Sanati‐Nezhad

Isolation of circulating tumor cells (CTCs) from blood has long been a challenge due to the rarity and heterogeneity of these cells. Detection technologies have predominantly focused on different molecular or physical properties of CTCs. Size-based isolation approach using microfilters have been …

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Synthesis of Highly Sensitive Graphene Nanocomposite for Biosensing Glial Fibrillary Acidic Protein (GFAP)

Sultan Khetani, Varun Kundra, Amir Sanati‐Nezhad

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