Accès ouvert
2023
article
OpenAlex
Ramy Abramsky, Ceyda Acun, Jesse Alt, Hany Z. Aly et autres
BACKGROUND: Seizures are more common during the neonatal period than at any other age, occurring at a rate of 1.10-5.5 per 1,000 live births.Neonatal seizures occur during the fi rst 30 days of postnatal life and constitute a neurological emergency requiring prompt …
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Accès ouvert
2023
article
OpenAlex
Subhabrata Mitra, Kelly Harvey-Jones, Igor Kraev, Vinita Verma et autres
Neonatal seizures are commonly associated with acute perinatal brain injury, while understanding regarding the downstream molecular pathways related to seizures remains unclear. Furthermore, effective treatment and reliable biomarkers are still lacking. Post-translational modifications can contribute to changes in protein function, and post-translational …
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Accès ouvert
2023
article
OpenAlex
Kelly Harvey-Jones, Frédéric Lange, Vinita Verma, Gemma Bale et autres
Abstract Background Opportunities for adjunct therapies with cooling in neonatal encephalopathy are imminent; however, robust biomarkers of early assessment are lacking. Using an optical platform of broadband near-infrared spectroscopy and diffuse correlation spectroscopy to directly measure mitochondrial metabolism (oxCCO), oxygenation (HbD), cerebral …
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Accès ouvert
2022
article
OpenAlex
Vinita Verma, Frédéric Lange, Alan P Bainbridge, Kelly Harvey-Jones et autres
Brain tissue temperature is a dynamic balance between heat generation from metabolism, passive loss of energy to the environment, and thermoregulatory processes such as perfusion. Perinatal brain injuries, particularly neonatal encephalopathy, and seizures, have a significant impact on the metabolic and haemodynamic …
gb
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Accès ouvert
2022
article
OpenAlex
Rachel Howard, Runci Li, Kelly Harvey-Jones, Vinita Verma et autres
BACKGROUND: Neonatal seizures remain a significant cause of morbidity and mortality worldwide. The past decade has resulted in substantial progress in seizure detection and understanding the impact seizures have on the developing brain. Optical monitoring such as cerebral near-infrared spectroscopy (NIRS) and …
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