Camille E. Puronen

Pharmacokinetic assessment of subcutaneous rituximab hyaluronidase among Ugandan adults with CD20+ Diffuse Large B-Cell Lymphoma

Kelvin Roland Mubiru, Henry Ddungu, Scott V. Adams, Jacqueline Asea et autres

ABSTRACT Non-Hodgkin lymphoma (NHL) is the most common hematologic malignancy worldwide. In high-income countries (HICs), treatment outcomes for NHL have dramatically improved over the past 25 years in large part due to rituximab. However, these same benefits have not been realized in …

Ouganda, us (code pays fourni par la source)

Phase I Study of Subcutaneous Rituximab Hyaluronidase Combined With CHOP Chemotherapy for the Treatment of Diffuse Large B-Cell Lymphoma in Uganda

Manoj P. Menon, Henry Ddungu, Kelvin Roland Mubiru, Scott V. Adams et autres

PURPOSE: Patients with diffuse large B-cell lymphoma (DLBCL) who are treated in low-resource settings have inferior outcomes compared with those in high-resource settings. Rituximab, an anti-CD20 monoclonal antibody, when combined with chemotherapy, improves overall survival (OS) for DLBCL. However, in part due …

us, Ouganda (code pays fourni par la source)

A Phase 1 Study of Subcutaneous Rituximab Hyaluronidase Combined with Local Standard-of-Care Chemotherapy for the Treatment of Diffuse Large B-Cell Lymphoma in Uganda

Henry Ddugnu, Kelvin Roland Mubiru, Scott V. Adams, Jacqueline Asea et autres

Background: Patients with Diffuse Large B-Cell Lymphoma (DLBCL) who are treated in low-resource settings have inferior outcomes compared to those in high-resource settings, with 12-month overall survival (OS) rates typically under 50% with standard chemotherapy (Gopal et al. [PMID:26934054]). Rituximab, an anti-CD20 …

Ouganda, Afrique du Sud, us (code pays fourni par la source)

Implementation of EMR-integrated ovarian cancer clinical pathways.

Ali Duffens, Devansu S. Tewari, Nina D. Shah, Kathy Pan et autres

577 Background: Adhering to National Comprehensive Cancer Network (NCCN) Guidelines correlates with higher survival in ovarian cancer and serves as a measure of care quality. Adherence to guidelines however is relatively low, routinely reported to be less than 50%. Integration of clinical …

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Serial Analysis of the T-Cell Receptor β-Chain Repertoire in People Living With HIV Reveals Incomplete Recovery After Long-Term Antiretroviral Therapy

Andrea M. H. Towlerton, Shashidhar Ravishankar, David Glen Coffey, Camille E. Puronen et autres

Long-term antiretroviral therapy (ART) in people living with HIV (PLHIV) is associated with sustained increases in CD4+ T-cell count, but its effect on the peripheral blood T-cell repertoire has not been comprehensively evaluated. In this study, we performed serial profiling of the …

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Immunotherapy in People With HIV and Cancer

Camille E. Puronen, Emily S. Ford, Thomas S. Uldrick

HIV infection alters the natural history of several cancers, in large part due to its effect on the immune system. Immune function in people living with HIV may vary from normal to highly dysfunctional and is largely dependent on the timing of …

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Analysis of the Potential Cost Utility of the Addition of Rituximab to Standard Chemotherapy in Adults with Aggressive B Cell Non-Hodgkin Lymphoma in Uganda

Camille E. Puronen

Thesis (Master's)--University of Washington, 2019

Long-Term Follow-Up of 90Y-Ibritumomab Tiuxetan, Fludarabine, and Total Body Irradiation–Based Nonmyeloablative Allogeneic Transplant Conditioning for Persistent High-Risk B Cell Lymphoma

Camille E. Puronen, Ryan Daniel Cassaday, Philip A. Stevenson, Brenda M. Sandmaier et autres

Nonmyeloablative allogeneic hematopoietic cell transplantation (HCT) can provide prolonged remissions in patients with advanced B cell lymphoma (B-NHL) via the graft-versus-lymphoma effect, although inferior results are seen in patients with chemoresistant, bulky, or aggressive disease. Radioimmunotherapy can safely induce responses in B-NHL …

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Acquired von Willebrand syndrome in a patient with monoclonal gammopathy of undetermined significance

Camille E. Puronen, Neil C. Josephson, Virginia C. Broudy

Acquired von Willebrand syndrome (AVWS) is a rare bleeding disorder that typically presents as mucocutaneous bleeding in individuals with no personal or family history of bleeding disorder. Here we present a case in which a patient presented with profound epistaxis and was …

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Decreased Interleukin 7 Responsiveness of T Lymphocytes in Patients With Idiopathic CD4 Lymphopenia

Camille E. Puronen, William L. Thompson, Hiromi Imamichi, Stéphanie Beq et autres

BACKGROUND: Elevated serum interleukin 7 (IL-7) levels are observed in lymphopenic conditions, including idiopathic CD4 lymphopenia (ICL), which is characterized by CD4 lymphopenia in the absence of human immunodeficiency virus infection or other known immunodeficiency. METHODS: To test whether defective IL-7 signaling …

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Higher Levels of CRP, D-dimer, IL-6, and Hyaluronic Acid Before Initiation of Antiretroviral Therapy (ART) Are Associated With Increased Risk of AIDS or Death

David R. Boulware, Katherine Huppler Hullsiek, Camille E. Puronen, Adam W. Rupert et autres

BACKGROUND: Substantial morbidity occurs during the first year of antiretroviral therapy (ART) in persons with advanced human immunodeficiency virus (HIV) disease despite HIV suppression. Biomarkers may identify high-risk groups. METHODS: Pre-ART and 1-month samples from an initial ART trial were evaluated for …

us, au (code pays fourni par la source)

PS1-32 Decreased IL-7 responsiveness of T lymphocytes in patients with idiopathic CD4 lymphopenia

Camille E. Puronen, William L. Thompson, Hiromi Imamichi, Stéphanie Beq et autres

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