Huidi Xie

Fucoidan attenuates renal fibrosis by alleviating tubular ectopic lipid deposition through sirtuin 1/forkhead box protein O1/adipose triglyceride lipase-associated lipophagy

Jiaming Su, Hongfang Liu, Jing Peng, Yan Guo et autres

) and TGF-β1/palmitic acid-stimulated HK-2 cells (FPS, 100-400 μg/mL). FPS improved renal function, ameliorated systemic and intrarenal lipid metabolic disturbances, reduced renal lipid deposition, and attenuated tubular injury and interstitial fibrosis. Mechanistically, FPS restored lipophagy-related processes, with increased Beclin1/Atg5/LC3-II and Rab7, reduced …

cn (code pays fourni par la source)

Traditional Chinese Medicine related factors of planned dialysis in chronic kidney disease stage 5 patients with type 2 diabetes mellitus: a multicenter cross-sectional study.

Ruimin ZHANG, Shuang LI, Yilun Qu, Qian WANG et autres

OBJECTIVE: To clarify the distribution of Traditional Chinese Medicine (TCM) symptoms, syndrome elements and complications in chronic kidney disease stage 5 (CKD5) patients with type 2 diabetes mellitus (T2DM), and to analyze the correlation factors between dialysis and non-dialysis patients, so as …

cn (code pays fourni par la source)

QiDiTangShen granules alleviates diabetic nephropathy podocyte injury: A network pharmacology study and experimental validation in vivo and vitro

Fei Gao, Ying Zhou, Borui Yu, Huidi Xie et autres

Background QiDiTangShen granules (QDTS), a traditional Chinese medicine (TCM) compound prescription, have remarkable efficacy in diabetic nephropathy (DN) patients, and their pharmacological mechanism needs further exploration. Methods According to the active ingredients and targets of the QDTS in the TCMSP database, the …

cn (code pays fourni par la source)

Identification of endoplasmic reticulum stress-related biomarkers of diabetes nephropathy based on bioinformatics and machine learning

Jiaming Su, Jing Peng, Linlin Wang, Huidi Xie et autres

Backgrounds: Diabetes nephropathy (DN) is a growing public health concern worldwide. Renal dysfunction impairment in DN is intimately linked to ER stress and its related signaling pathways. Nonetheless, the underlying mechanism and biomarkers for this function of ER stress in the DN …

cn (code pays fourni par la source)

Identification of endoplasmic reticulum stress-related biomarkers of diabetes nephropathy based on bioinformatics and machine learning

Jiaming Su, Jing Peng, Linlin Wang, Huidi Xie et autres

Abstract Background: Diabetes nephropathy (DN) is a growing public health concern worldwide. Renal dysfunction impairment in DN is intimately linked to ER stress and its related signaling pathways. Nonetheless, the underlying mechanism and biomarkers for this function of ER stress in the …

cn (code pays fourni par la source)

Prevalence of diabetic nephropathy in the diabetes mellitus population: A protocol for systematic review and meta-analysis

Sicheng Li, Huidi Xie, Yang Shi, Hongfang Liu

BACKGROUND: Diabetic nephropathy (DN) is the leading cause of end-stage renal disease worldwide, placing enormous pressure on healthcare systems and creating a heavy socioeconomic burden. It is urgent to comprehensively study the epidemiological characteristics of DN in diabetic patients and to analyze …

cn (code pays fourni par la source)

TMBIM6 promotes diabetic tubular epithelial cell survival and albumin endocytosis by inhibiting the endoplasmic reticulum stress sensor, IRE1α

Huidi Xie, Yang Shi, Ying Zhou, Hongfang Liu

cn (code pays fourni par la source)

Evaluation of Renal Impairment in Patients with Diabetic Kidney Disease by Integrated Chinese and Western Medicine

Yilun Qu, Zheyi Dong, Hai-mei Cheng, Qian Liu et autres

cn (code pays fourni par la source)

IDF21-0628 Transmembrane bax inhibitor motif containing 6: a potential biomarker for tubular injury in type 2 diabetes

Huidi Xie, H. Liu, Yun Shi, Yufeng Zhou

cn (code pays fourni par la source)

Effects of Qidi Tangshen granules and their separate prescriptions on podocytes in mice with diabetic nephropathy

Borui Yu, Hongfang Liu, Xue Gao, Qingqing Liu et autres

Previous studies have found that Qidi Tangshen granules (QDTS), a combination therapy of supplementing essence (Tianjing, TJ) and unblocking the collaterals (Tongluo, TL), can reduce kidney damage in db/db mice. This study aimed to explore the effect of QDTS and their separate …

cn (code pays fourni par la source)

Transmembrane bax inhibitor motif containing 6: a potential biomarker for tubular injury in type 2 diabetes

Huidi Xie

QiDiTangShen granules modulated the gut microbiome composition and improved bile acid profiles in a mouse model of diabetic nephropathy

Huili Wei, Lin Wang, Zhichao An, Huidi Xie et autres

QiDiTangShen granules (QDTS), a traditional Chinese herbal medicine, have been used in clinical practice for treating diabetic kidney disease for several years. In our previous study, we have demonstrated that QDTS displayed good efficacy on reducing proteinuria in mice with diabetic nephropathy …

cn (code pays fourni par la source)