Michele Pellegrini

Incidence of skin and soft-tissue infections in England: 11-year retrospective study

Venanzio Vella, Dominique Derreumaux, Emmanuel Aris, Sashi Mehra et autres

Epidemiological estimates for the incidence of skin and soft-tissue infections (SSTIs) in England are limited. We aimed at evaluating the incidence of SSTIs and associated complications through a retrospective, observational 11-year study (2010-2020). We retrieved data on SSTI and associated complications from …

MSR29 Application of Network Meta-Analysis in Vaccine Research: An Illustration Using Immunogenicity of Pneumococcal Vaccines in Adults

Naveen Karkada, Michele Pellegrini, Shite Sebastian

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Long-term persistence and boostability of immune responses following different rabies pre-exposure prophylaxis priming schedules of a purified chick embryo cell rabies vaccine administered alone or concomitantly with a Japanese encephalitis vaccine

Tomáš Jelı́nek, Mirjam Schunk, Emil C. Reisinger, Marylyn M. Addo et autres

BACKGROUND: Rabies pre-exposure prophylaxis (PrEP) is recommended to individuals at risk for exposure to rabies. Three intramuscular doses of the purified chick embryo cell (PCEC) rabies vaccine can be administered according to a conventional (four-week) or an accelerated (one-week) regimen. METHODOLOGY/PRINCIPAL FINDINGS: …

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The Incidence of Skin and Soft Tissue Infections in the United States and Associated Healthcare Utilization Between 2010 and 2020

Venanzio Vella, Dominique Derreumaux, Emmanuel Aris, Michele Pellegrini et autres

Abstract Background The number of patients with skin and soft tissue infections (SSTIs) in the United States appeared to be increasing well into the 21st century. However, no recent data have confirmed this trend. Methods This retrospective, observational cohort study used claims …

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PCR82 Hierarchical Clustering of Rare Diseases Based on Functional Impacts to Support the Identification of Potential Patient-Centered Outcomes Measures for Rare Diseases Research

T Vilcot, C. Desvignes-Gleizes, G. Mc Donough, Marta Martins Pereira et autres

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Incidence, associated disease burden and healthcare utilization due to Staphylococcus aureus prosthetic joint infection in European hospitals: the COMBACTE-NET ARTHR-IS multi-centre study

Roseli de Moura Espíndola, Venanzio Vella, Natividad Benito, Isabel Mur et autres

BACKGROUND: The aim of this study was to estimate the incidence, associated disease burden and healthcare utilization due to Staphylococcus aureus prosthetic joint infections (SA-PJI) after primary hip and knee arthroplasty in European centres. METHODS: This study was conducted in patients who …

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Re‐randomization tests as sensitivity analyses to confirm immunological noninferiority of an investigational vaccine: Case study

Luca Grassano, Giulia Ranzato, Michele Pellegrini, Marco Costantini

Here we present as case study how re-randomization tests were performed in two randomized, controlled clinical trials as sensitivity analyses, as recommended by the United States Food and Drug Administration in the context of adaptive randomization. This was done to confirm primary …

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PCR243 Facilitating and Accelerating Patient-Reported Outcomes (PRO) Selection to Use for Clinical Research and Rare Diseases (RD) - A European Rare Disease Research Coordination and Support Action (ERICA) Project

C. Desvignes-Gleizes, T Vilcot, G. Mc Donough, Michele Pellegrini et autres

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A data-driven modeling approach for the sustainable remediation of persistent arsenic (As) groundwater contamination in a fractured rock aquifer through a groundwater recirculation well (IEG-GCW®)

Paolo Ciampi, Carlo Esposito, Ernst Bartsch, Eduard J. Alesi et autres

Persistent arsenic (As) pollution sources from anthropogenic activities pose a serious threat to groundwater quality. This work aims to illustrate the application of an innovative remediation technology to remove As from a heavily contaminated fractured aquifer at a historically polluted industrial site. …

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Fully Liquid MenACWY-CRM Vaccine: Results from an Integrated Safety Analysis

Puneet Vir Singh, Paola Tiberi, Gabriele Filippo Di Domenico, Valerio Romolini et autres

INTRODUCTION: The currently licensed quadrivalent MenACWY-CRM conjugate vaccine presentation consists of two vials (lyophilized MenA and liquid MenCWY) to be reconstituted before injection. A new fully liquid, single-vial formulation has been developed to simplify administration and prevent reconstitution errors. We present pooled …

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Correction to: A Decade of Fighting Invasive Meningococcal Disease: A Narrative Review of Clinical and Real-World Experience with the MenACWY-CRM Conjugate Vaccine

Yara Ruiz García, Véronique Abitbol, Michele Pellegrini, Rafik Bekkat-Berkani et autres

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632. Clinical Experience with a New Fully Liquid Presentation of the MenACWY-CRM Vaccine. Results from Two Multicenter, Randomized, Controlled, Observer-Blind, Phase 2b Studies

Javier Díez‐Domingo, Corinne Vandermeulen, Tauseefullah Akhund, Marco Costantini et autres

Abstract Background Currently, licensed MenACWY-CRM conjugate vaccine presentation (Lyo/Liq) consists of two vials (lyophilized MenA, liquid MenCWY) to be reconstituted before injection. A new, fully liquid, single vial formulation has been developed and evaluated in two clinical studies in adolescents and adults …

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