Anna Maslarova

Assessing Pupil Diameter as an Indicator of Arousal State to Distinguish Hippocampal Neural Rhythms During Wakefulness (P1-6.008)

Joyce Zhu, Anna Maslarova, Jiyun Shin, Forouzan Farahani et autres

We determined whether pupil could serve as a reliable measure of arousal state to distinguish awake neural rhythms (e.g. hippocampal theta, gamma) from resting neural rhythms (e.g. hippocampal SPW-Rs) important for memory encoding and consolidation.

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Spatiotemporal patterns differentiate hippocampal sharp-wave ripples from interictal epileptiform discharges in mice and humans

Anna Maslarova, Jiyun N. Shin, Andrea Navas-Olivé, Mihály Vöröslakos et autres

Hippocampal sharp-wave ripples (SPW-Rs) are high-frequency oscillations critical for memory consolidation. Despite extensive characterization in rodents, their detection in humans is limited by coarse spatial sampling, interictal epileptiform discharges (IEDs), and a lack of consensus on human ripple localization and morphology. Here, …

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Blood–brain barrier opening as a predictor of epilepsy and mortality after subarachnoid haemorrhage

Jens Peter Dreier, Svetlana Lublinsky, Viktor Horst, Sebastian Major et autres

BACKGROUND: We determined the predictive power of semi-automated blood-brain barrier assessment and other variables collected during neurocritical care for the outcome of 'epilepsy or late death' following aneurysmal subarachnoid haemorrhage. METHODS: This is a secondary analysis of the prospective, non-interventional, prognostic DISCHARGE-1-cohort …

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Electroanatomy of hippocampal activity patterns: theta, gamma waves, sharp wave-ripples, and dentate spikes

Nicholas Paleologos, Mihály Vöröslakos, Joaquín Antonio González, Anna Maslarova et autres

Monitoring representative fractions of neurons from multiple brain circuits in behaving animals is necessary for understanding how different brain regions interact. Using multishank, high-density recording silicon probes (up to 1,024 sites), we describe the main characteristic LFP patterns in the hippocampus, including …

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Spatiotemporal Patterns Differentiate Hippocampal Sharp-Wave Ripples from Interictal Epileptiform Discharges in Mice and Humans

Anna Maslarova, Jiyun N. Shin, Andrea Navas-Olivé, Mihály Vöröslakos et autres

Hippocampal sharp-wave ripples (SPW-Rs) are high-frequency oscillations critical for memory consolidation in mammals. Despite extensive characterization in rodents, their application as biomarkers to track and treat memory dysfunction in humans is limited by coarse spatial sampling, interference from interictal epileptiform discharges (IEDs), …

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Self supervised learning for in vivo localization of microelectrode arrays using raw local field potential

Tianxi He, Malhar Patel, Chenyi Li, Anna Maslarova et autres

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Interictal epileptiform discharges affect memory in an Alzheimer’s disease mouse model

Marisol Soula, Anna Maslarova, Ryan E. Harvey, Manuel Valero et autres

Interictal epileptiform discharges (IEDs) are transient abnormal electrophysiological events commonly observed in epilepsy patients but are also present in other neurological diseases, such as Alzheimer's disease (AD). Understanding the role IEDs have on the hippocampal circuit is important for our understanding of …

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Interictal epileptiform discharges affect memory in an Alzheimer’s Disease mouse model

Marisol Soula, Anna Maslarova, Ryan E. Harvey, Manuel Valero et autres

Interictal epileptiform discharges (IEDs) are transient abnormal electrophysiological events commonly observed in epilepsy patients but are also present in other neurological disease, such as Alzheimer's Disease (AD). Understanding the role IEDs have on the hippocampal circuit is important for our understanding of …

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Surgical planning, histopathology findings and postoperative outcome in MR-negative extra-temporal epilepsy using intracranial EEG, functional imaging, magnetoencephalography, neuronavigation and intraoperative MRI

Anna Maslarova, Yining Zhao, Julie Rösch, Arnd Dörfler et autres

OBJECTIVE: MRI-negative drug-resistant epilepsy presents a challenge when it comes to surgical planning, and surgical outcome is worse than in cases with an identified lesion. Although increasing implementation of more powerful MRI scanners and artificial intelligence has led to the detection of …

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Status epilepticus induces chronic silencing of burster and dominance of regular firing neurons during sharp wave-ripples in the mouse subiculum

Kristina Lippmann, Zin‐Juan Klaft, Seda Salar, Jan‐Oliver Hollnagel et autres

Sharp wave-ripples (SWRs) are hippocampal oscillations associated with memory consolidation. The subiculum, as the hippocampal output structure, ensures that hippocampal memory representations are transferred correctly to the consolidating neocortical regions. Because patients with temporal lobe epilepsy often develop memory deficits, we hypothesized …

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Surgical hematoma evacuation of cortical intracerebral hemorrhage ≥10 ml reduces risk of subsequent epilepsy by more than 70%: A retrospective monocenter study

Tamara M. Welte, Josephine Steidl, Jenny Stritzelberger, Stephanie Gollwitzer et autres

AIM: The aim of this study was to re-evaluate risk factors for post-ICH epilepsy (PICHE) and examine the impact of surgical hematoma evacuation on epilepsy development after ICH. BACKGROUND AND PURPOSE: Epilepsy is a common complication after intracerebral hemorrhage (ICH). Information on …

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Status epilepticus induces chronic silencing of burster and dominance of regular firing neurons during sharp wave-ripples in the mouse subiculum

Kristina Lippmann, Zin‐Juan Klaft, Seda Salar, Jan‐Oliver Hollnagel et autres

Abstract Sharp wave-ripples (SWRs) are hippocampal oscillations associated with memory consolidation. The subiculum, as the hippocampal output structure, ensures that hippocampal memory representations are transferred correctly to the consolidating neocortical regions. Because patients with temporal lobe epilepsy often develop memory deficits, we …

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