Marius Ataman

Dominance of mutations in epigenetic regulators and a diversity of signaling alterations in blast‐phase BCR::ABL1 ‐negative myeloproliferative neoplasms

Petruta Gurban, Cristina Mambet, Anca Botezatu, Laura Necula et autres

TO THE EDITOR : BCR::ABL1-negative myeloproliferative neoplasms (MPNs) can evolve to secondary acute myeloid leukemia (sAML) or blast-phase (BP) MPN, a very severe condition with lack of effective therapy.1 Leukemic transformation (LT) of MPNs displays a variable incidence according to MPN phenotype: …

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Increased mRNA expression for serotonin receptor 1B (HTR1B) is associated with thrombosis in BCR::ABL1‐negative myeloproliferative neoplasms

Petruta Gurban, Cristina Mambet, Anca Botezatu, Laura Necula et autres

BCR::ABL1-negative myeloproliferative neoplasms (MPNs) are clonal haematopoietic stem cell disorders characterized by specific driver mutations and an increased risk of both macrothrombosis and microthrombosis. Serotonin receptor type 1B (HTR1B) was found to be expressed by various solid tumours, and also primary bone …

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Assessment of Total Antioxidant Capacity, 8-Hydroxy-2′-deoxy-guanosine, the Genetic Landscape, and Their Associations in BCR::ABL-1-Negative Chronic and Blast Phase Myeloproliferative Neoplasms

Mihnea‐Alexandru Găman, Cristina Mambet, Ana Iulia Neagu, Coralia Bleoţu et autres

Myeloproliferative neoplasms (MPNs), namely, polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF), are clonal stem cell disorders defined by an excessive production of functionally mature and terminally differentiated myeloid cells. MPNs can transform into secondary acute myeloid leukemia (sAML/blast phase …

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Leukemic conversion involving RAS mutations of type 1 CALR-mutated primary myelofibrosis in a patient treated for HCV cirrhosis: a case report

Petruta Gurban, Cristina Mambet, Anca Botezatu, Laura Necula et autres

Somatic frameshift mutations in exon 9 of calreticulin (CALR) gene are recognized as disease drivers in primary myelofibrosis (PMF), one of the three classical Philadelphia-negative myeloproliferative neoplasms (MPNs). Type 1/type 1-like CALR mutations particularly confer a favorable prognostic and survival advantage in …

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Kinetics and persistence of cellular and humoral immune responses to SARS‐CoV‐2 vaccine in healthcare workers with or without prior COVID‐19

Mihaela Chivu‐Economescu, Coralia Bleoţu, Camelia Grancea, Daniela Chiriac et autres

SARS-CoV-2 vaccines are highly efficient against severe forms of the disease, hospitalization and death. Nevertheless, insufficient protection against several circulating viral variants might suggest waning immunity and the need for an additional vaccine dose. We conducted a longitudinal study on the kinetics …

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Targets and assay types for COVID-19 diagnosis

Marinela Bostan, Marius Ataman, Ioana Stefania Bostan, Coralia Bleoţu

The lack of complete information on the immune response dynamics to infection with severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) has led to the use of mainly molecular tests such as reverse transcription PCR (RT-PCR) to diagnose Coronavirus 2019 disease (COVID-19). Although …

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Therapeutic potential of T regulatory cell manipulation: advantages and limitations

ANA I. NEAGU, Cristina Mambet, LAURA G NECULA, Lilia Matei et autres

Regulatory T cells have a central role in maintaining immune homeostasis by modulating immune responses and promoting tolerance to self-antigens.Treg cells are involved in autoimmune disease prevention, suppression of allergic diseases, confinement of infection-induced immunopathology, induction of fetal-maternal and oral tolerance.On the …

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Virusul Papiloma - potenţială cauză în cazul neoplasmelor orofaringian și laringian

Marius Ataman

The author reviews the Papillomaviruses potentially responsible for the occurence of oro-pharyngo-laryngial cancers in humans, as well as the procedures used in their identification by molecular techniques.

Poststapedectomy reparative granuloma

Marius Ataman, Bülent Sözeri, Tuncay Özçelik, T. Sarıoğlu

A case of poststapedectomy reparative granuloma is reported together with the review of literature. Although classical textbooks of otolaryngology deal with this problem, we could not find recent literature about this unpleasant pathology and this has prompted us to report the present …