Bronwyn A. Ellis

A summary of the main themes and findings presented at the ASM Intermountain Branch meeting (2024)

Jay R. Radke, Javier Ochoa‐Repáraz, Jamee Nixon, Sajal Acharya et autres

The annual meeting for the Intermountain Branch was held in April 2024 on the campus of Brigham Young University. There were 127 branch members from Utah, Idaho, and Nevada who attended the meeting and were composed of undergraduate students, graduate or medical …

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Changes in Aerobic Capacity and Visceral Fat but not Myocyte Lipid Levels Predict Increased Insulin Action After Exercise in Overweight and Obese Men

Seng Khee Gan, Adamandia D. Kriketos, Bronwyn A. Ellis, Campbell Henry Thompson et autres

OBJECTIVE: To examine the effect of moderate intensity physical activity on the interactions between central abdominal adiposity, myocyte lipid content, and insulin action in overweight and obese, sedentary men. RESEARCH DESIGN AND METHODS: Myocyte lipid (biochemical triglyceride and long-chain acyl CoA [LCAC] …

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Nicotinic acid-induced insulin resistance is related to increased circulating fatty acids and fat oxidation but not muscle lipid content

Ann M. Poynten, Seng Khee Gan, Adamandia D. Kriketos, Anthony O’Sullivan et autres

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PPARα/γ ragaglitazar eliminates fatty liver and enhances insulin action in fat-fed rats in the absence of hepatomegaly

Ji‐Ming Ye, Miguel A. Iglesias, David George Watson, Bronwyn A. Ellis et autres

Peroxisome proliferator-activated receptor (PPAR)alpha and PPARgamma agonists lower lipid accumulation in muscle and liver by different mechanisms. We investigated whether benefits could be achieved on insulin sensitivity and lipid metabolism by the dual PPARalpha/gamma agonist ragaglitazar in high fat-fed rats. Ragaglitazar completely …

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Prior Thiazolidinedione Treatment Preserves Insulin Sensitivity in Normal Rats during Acute Fatty Acid Elevation: Role of the Liver

Ji‐Ming Ye, Georgia Frangioudakis, Miguel A. Iglesias, Stuart M. Furler et autres

Thiazolidinediones lower lipids, but it is unclear whether this is essential for their insulin-sensitizing action. We investigated relationships between lipid-lowering and insulin-sensitizing actions of a thiazolidinedione. Normal rats were pretreated with or without Pioglitazone (Pio, 3 mg/kg.d) for 2 wk. Insulin sensitivity …

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Acyl-CoA Binding Protein Expression Is Fiber Type- Specific and Elevated in Muscles From the Obese Insulin-Resistant Zucker Rat

Jesper Franch, Jens Knudsen, Bronwyn A. Ellis, Preben K. Pedersen et autres

Accumulation of acyl-CoA is hypothesized to be involved in development of insulin resistance. Acyl-CoA binds to acyl-CoA binding protein (ACBP) with high affinity, and therefore knowledge about ACBP concentration is important for interpreting acyl-CoA data. In the present study, we used a …

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Independent Influences of Central Fat and Skeletal Muscle Lipids on Insulin Sensitivity

Stuart M. Furler, Ann M. Poynten, Adamandia D. Kriketos, Andrew J. Lowy et autres

OBJECTIVE: Insulin resistance is closely associated with two disparate aspects of lipid storage: the intracellular lipid content of skeletal muscle and the magnitude of central adipose beds. Our aim was to determine their relative contribution to impaired insulin action. RESEARCH METHODS AND …

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Long-chain acyl-CoA esters as indicators of lipid metabolism and insulin sensitivity in rat and human muscle

Bronwyn A. Ellis, Ann M. Poynten, Andrew J. Lowy, Stuart M. Furler et autres

Long-chain acyl-CoAs (LCACoA) are an activated lipid species that are key metabolites in lipid metabolism; they also have a role in the regulation of other cellular processes. However, few studies have linked LCACoA content in rat and human muscle to changes in …

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Cytosolic citrate and malonyl-CoA regulation in rat muscle in vivo

Asish Kumar Saha, D. Ross Laybutt, David J. Dean, Demetrios G. Vavvas et autres

In liver, insulin and glucose acutely increase the concentration of malonyl-CoA by dephosphorylating and activating acetyl-CoA carboxylase (ACC). In contrast, in incubated rat skeletal muscle, they appear to act by increasing the cytosolic concentration of citrate, an allosteric activator of ACC, as …

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Stereoselective and substrate-dependent inhibition of hepatic mitochondrial β-oxidation and oxidative phosphorylation by the non-steroidal anti-inflammatory drugs ibuprofen, flurbiprofen, and ketorolac

Gary Browne, Carolyn Nelson, Tuan A.H. Nguyen, Bronwyn A. Ellis et autres

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