Accès ouvert
2025
article
OpenAlex
Biao Yu, Kangkang Mei, D. Zhan, Qi Tang et autres
BACKGROUND AND OBJECTIVES: Vancomycin (VCM) pharmacokinetic parameters vary widely between individuals. Existing models developed domestically and internationally may not apply universally because of differences in patient populations and testing methodologies. Therefore, the present study aimed to address the clinical challenge of optimizing …
cn
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Accès ouvert
2025
article
OpenAlex
Biao Yu, Ying Wan, Kangkang Mei, D. Zhan et autres
Purpose: The current study was designed to develop and validate a population pharmacokinetic (PPK) model of methotrexate (MTX) in pediatric patients with acute lymphoblastic leukemia (ALL). We aimed to develop a PPK model to evaluate the effects of potential covariates and explore …
cn
(code pays fourni par la source)
2025
article
OpenAlex
Heping Cai, Zaibang Feng, Rui Guo, Kangkang Mei et autres
BACKGROUND: Post-stroke seizures and epilepsy can affect patients' quality of life, increase mortality in stroke patients, affect patient outcomes, and are associated with higher medical expenditures. However, little is known about the risk factors that influence the onset post-stroke seizures and epilepsy. …
cn
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Accès ouvert
2019
article
OpenAlex
Kangkang Mei, Guo‐Kai Wang, Heping Cai, Bai-Xiang Cai
A new Cephalotaxus alkaloid, namely Cephalounei A (1), was isolated from the stems of Cephalotaxus fortune Hook. f. Their structures were elucidated by spectroscopic and mass-spectrometric analyses, including 1D-, 2D-NMR and HRESIMS. The relative and absolute stereochemistry of 1 was determined by …
it, cn, us
(code pays fourni par la source)
2016
article
OpenAlex
Kangkang Mei, Zhihong Luo, Jian Wang, Lijun Qu
Mercaptopurine is used to treat children with acute lymphoblastic leukemia. Mercaptopurine can cause bone marrow suppression and liver toxicity, threatening the lives of children, resulting in interruption or discontinuation of the chemotherapy, increasing the risk of disease recurrence. The mercaptopurine dosage regimens …
cn
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