Yuyang Gu

Regorafenib and Nifuroxazide exert enhanced suppression of hepatocellular carcinoma by inhibiting STAT3 and immune remodeling

Kun Li, Jinwei Chen, Zhi Ping Zheng, Yichun Gao et autres

, H22 tumor‑bearing mice treated with the combination exhibited suppressed tumor growth without systemic toxicity, along with changes in apoptotic proteins, enhanced tumor‑infiltrating immune cells and improved systemic immune responses. These findings indicated that the combination exerts enhanced suppression of HCC by …

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Clinical Features and Treatment Strategies of Li‐Fraumeni Syndrome Patients With Inherited TP53 Mutations

Keyu Chen, Yufen Xu, Binbin Song, Yuyang Gu et autres

BACKGROUND: Li-Fraumeni syndrome is a rare autosomal dominant disorder caused by a pathogenic mutation of the tumor suppressor gene TP53. This disease starts at an early age and has been shown to be associated with multiple tumors. The study aims to discuss …

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High TRA2B expression mediated by ncRNA correlates with adverse outcomes and tumor immune infiltration in hepatocellular carcinoma

Yanjun Li, Yefan Zhang, Qijun Li, Yuyang Gu et autres

Hepatocellular carcinoma (HCC) is one of the most frequent diagnosed malignancies globally with dismalprognosis and high mortality. Transformer 2 beta homolog (TRA2B), known as serine/arginine-rich splicing factor 10 (SRSF10), is a member of the serine/arginine (SR) protein superfamily that modulates gene expression …

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Flexible acoustic and shear wave control for elasticity imaging

Yuyang Gu

Shear wave elasticity imaging is a key technique for noninvasive tissue stiffness assessment, widely used in diagnosing conditions such as liver fibrosis. However, the complex in vivo environment often distorts acoustic and shear wave behavior, leading to inaccurate and high-variance results. Here, …

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CLEC11A as a potential biomarker for prognosis and response to immunotherapy in colon adenocarcinoma

Yuyang Gu, Yanjun Li, Tingting Qian, Xiaofang Xu

Colon adenocarcinoma (COAD) ranks among the most prevalent malignancies. C-type lectin domain family 11 member A (CLEC11A) plays a role in the initiation and progression of various cancers. However, its involvement in COAD remains unclear. This study reveals that CLEC11A expression is …

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NOLC1 suppresses immunochemotherapy by inhibiting p53-mediated ferroptosis in gastric cancer

Shengsheng Zhao, Ji Lin, Bingzi Zhu, Yin Jin et autres

Human gastric cancer (GC) is one of the most malignant cancers, and cisplatin (Cis)-based chemotherapy remains the main clinical treatment for GC. However, Cis resistance often occurs, largely limiting its therapeutic efficacy in tumors. Therefore, a better understanding of the drug resistance …

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Author response: NOLC1 suppresses immunochemotherapy by inhibiting p53-mediated ferroptosis in gastric cancer

Shengsheng Zhao, Ji Lin, Bingzi Zhu, Yin Jin et autres

NOLC1 inhibits p53 nuclear accumulation and transcription, subsequently suppresses cisplatin-induced ferroptosis, and promotes an immunosuppressive microenvironment, eventually suppressing immunochemotherapy in gastric cancer.

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Author response: NOLC1 Suppresses Immuno-chemotherapy by Inhibiting p53-mediated Ferroptosis in Gastric Cancer

Shengsheng Zhao, Ji Lin, Bingzi Zhu, Yin Jin et autres

Gastric cancer (GC) is one of the most malignant cancers, and cisplatin (Cis)-based chemotherapy remains the main clinical treatment for GC. However, Cis resistance often occurs, largely limiting its therapeutic efficacy in tumors. Therefore, a better understanding of the drug resistance mechanism …

NOLC1 Suppresses Immuno-chemotherapy by Inhibiting p53-mediated Ferroptosis in Gastric Cancer

Shengsheng Zhao, Ji Lin, Bingzi Zhu, Yin Jin et autres

Abstract Gastric cancer (GC) is one of the most malignant cancers, and cisplatin (Cis)-based chemotherapy remains the main clinical treatment for GC. However, Cis resistance often occurs, largely limiting its therapeutic efficacy in tumors. Therefore, a better understanding of the drug resistance …

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Acoustofluidic spin control for 3D particle manipulation in droplets

Chuyi Chen, Yuyang Gu, Joseph Rufo, Jinxin Zhang et autres

The rotation of objects and corresponding dynamic systems plays a critical role in applications ranging from microscale droplet-based biochemical assays to nanoscale fluid transport and targeted drug delivery. However, directly observing and controlling these rotational phenomena across these different scales remains a …

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Microplastics in road sediment of typical urban districts of Beijing: Characteristics and risk assessment

Yuyang Gu, Xiaoran Zhang, Junfeng Liu, Jie Deng et autres

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Combining Deep Data-Driven and Physics-Inspired Learning for Shear Wave Speed Estimation in Ultrasound Elastography

Ali K. Z. Tehrani, Scott Joseph Schoen, Ion Candel, Yuyang Gu et autres

The shear wave elastography (SWE) provides quantitative markers for tissue characterization by measuring the shear wave speed (SWS), which reflects tissue stiffness. SWE uses an acoustic radiation force pulse sequence to generate shear waves that propagate laterally through tissue with transient displacements. …

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