Veena Gullapalli

Cell-state-specific mechanisms of 5-azacytidine response in myelodysplastic neoplasms

Golam Sarower Bhuyan, Alex Yan, Mary N.T. Nguyen, Hoi Man Chung et autres

Abstract 5-azacytidine improves haematopoiesis and delays leukaemic progression in myelodysplastic neoplasms, but responses vary and are complicated by clonal mosaicism and heterogenous demethylation. Using a novel single-cell pipeline (“SCIMETAR-seq”), we found 5-azacytidine induced clonally distinct differentiation responses, with nuclear DNA demethylation occurring …

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Re-treatment of relapse in elderly AML with time-limited venetoclax-based regimen: a case report and literature review

Jun Yen Ng, Veena Gullapalli, Jad Othman, Dipti Talaulikar

Venetoclax and hypomethylating agent combination therapy is now the standard of care in acute myeloid leukemia (AML) for patients ineligible for intensive therapy, including the elderly; however, venetoclax and low-dose cytarabine remain a viable option for select patients. Relapse in this cohort …

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Re-treatment of relapse in elderly AML with time-limited venetoclax-based regimen: A case report and literature review.

Jun Yen Ng, Veena Gullapalli, Jad Othman, Dipti Talaulikar

Abstract Background Relapse in elderly AML remains a significant challenge. In VIALE-A, 52% and 74% of participants (age >75) with previously untreated AML in the venetoclax (VEN)+azacitidine (AZA) and AZA+placebo arms developed progressive disease (PD) or morphologic relapse (MR) after a median …

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Integrative Genetic Profiling of Circulating Tumour DNA and Bone Marrow for Multiple Myeloma Prognostication

Regina Kwarteng, Yvonne Kong, Stephanie Talam, Shihong Yang et autres

Tranexamic acid versus placebo to prevent bleeding in patients with haematological malignancies and severe thrombocytopenia (TREATT): a randomised, double-blind, parallel, phase 3 superiority trial

Lise J Estcourt, Zoe McQuilten, Peter Bardy, Merrole Faye Cole-Sinclair et autres

Synchronous Development of Acute Megakaryoblastic Leukaemia and Disseminated Melanoma following Treatment of a Germ Cell Tumour: A Case Report

Veena Gullapalli, Hannah Hsu, Vanita Bhargava, Peter Presgrave

Somatic malignant transformation of germ cell tumours is a well-described but poorly understood phenomenon. It is characterized by differentiation of pluripotent teratoma cells into somatic tumour cells. Following malignant transformation, the most common histologies are sarcomas and primitive neuroectodermal tumours; however, other …

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Management and Outcomes of Diffuse Large B-cell Lymphoma Post-transplant Lymphoproliferative Disorder in the Era of PET and Rituximab: A Multicenter Study From the Australasian Lymphoma Alliance

Stephen Boyle, Joshua W.D. Tobin, Jacinta Perram, Nada Hamad et autres

There are limited data on post-transplant lymphoproliferative disorder (PTLD) in the era of positron emission tomography (PET) and rituximab (R). Furthermore, there is limited data on the risk of graft rejection with modern practices in reduction in immunosuppression (RIS). We studied 91 …

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A multi-centre case series of alectinib-related erythrocyte membrane changes and associated haemolysis

Veena Gullapalli, Wen Xu, Craig R. Lewis, Antoinette Catherine Anazodo et autres

Abstract Alectinib is an orally bioavailable anaplastic lymphoma kinase (ALK) inhibitor indicated for ALK mutated non-small cell lung cancer (NSCLC). This case series documents the development of significant erythrocyte membrane changes associated with alectinib use in six patients. Morphological findings found on …

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Management and Outcomes of Diffuse Large B Cell Lymphoma Post-Transplant Lymphoproliferative Disorder in the PET/CT Era: A Multicentre Study from the Australasian Lymphoma Alliance

Stephen Boyle, Joshua W.D. Tobin, Jacinta Perram, Nada Hamad et autres

Introduction Post-transplant lymphoproliferative disorders (PTLD) are aggressive lymphomas which occur in solid organ transplant recipients and cause significant mortality. In the era of positron emission tomography (PET) staging and rituximab (R), there is limited real-world data on treatment outcomes and the incidence …

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Metastatic germ cell tumour presenting as acute megakaryoblastic leukaemia and disseminated melanoma: A case report

Hannah Hsu, Veena Gullapalli

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