Annamaria Cialdella

Correction: A novel oncogenic BTK isoform is overexpressed in colon cancers and required for RAS-mediated transformation

Emanuela Grassilli, Fabio Pisano, Annamaria Cialdella, Sara Bonomo et autres

Following the publication of this article, an error was detected in Figure 1b. Upon re-checking data, it was noted that the incorrect blot relating to the expression of actin in the peritumoral tissue of patients 11, 12, 13 was published. The corrected …

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BTK inhibitors synergise with 5‐FU to treat drug‐resistant TP53‐null colon cancers

Marialuisa Lavitrano, Leonarda Ianzano, Sara Bonomo, Annamaria Cialdella et autres

Colorectal cancer (CRC) is the fourth cause of death from cancer worldwide mainly due to the high incidence of drug-resistance. During a screen for new actionable targets in drug-resistant tumours we recently identified p65BTK - a novel oncogenic isoform of Bruton's tyrosine …

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p65BTK is a novel potential actionable target in KRAS-mutated/EGFR-wild type lung adenocarcinoma

Federica Giordano, Valentina Vaira, Diego Luigi Cortinovis, Sara Bonomo et autres

BACKGROUND: Lung cancer is still the main cause of cancer death worldwide despite the availability of targeted therapies and immune-checkpoint inhibitors combined with chemotherapy. Cancer cell heterogeneity and primary or acquired resistance mechanisms cause the elusive behaviour of this cancer and new …

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Specific Expression of a New Bruton Tyrosine Kinase Isoform (p65BTK) in the Glioblastoma Gemistocytic Histotype

Luca Sala, Giovanni Cirillo, Gabriele Riva, Gabriele Romano et autres

Bruton’s tyrosine-kinase (BTK) is a non-receptor tyrosine kinase recently associated with glioma tumorigenesis and a novel prognostic marker for poor survival in patients with glioma. The p65BTK is a novel BTK isoform involved in different pathways of drug resistance of solid tumors, …

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p65BTK targeting restores the apoptotic response to chemotherapy of p53-null drug-resistant colon cancer cells

Leonarda Ianzano, Sara Bonomo, Annamaria Cialdella, Fabio Pisano et autres

A novel oncogenic BTK isoform is overexpressed in colon cancers and required for RAS-mediated transformation

Emanuela Grassilli, Fabrizio Pisano, Annamaria Cialdella, S Bonomo et autres

Bruton's tyrosine kinase (BTK) is essential for B-cell proliferation/differentiation and it is generally believed that its expression and function are limited to bone marrow-derived cells. Here, we report the identification and characterization of p65BTK, a novel isoform abundantly expressed in colon carcinoma …

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Abstract B121: A novel oncogenic BTK isoform is overexpressed in colon cancers and required for RAS-mediated transformation

Emanuela Grassilli, Fabio Pisano, Annamaria Cialdella, Sara Bonomo et autres

Abstract It is known that Bruton's tyrosine kinase (BTK) is essential for B-cell proliferation/differentiation and it is generally believed that its expression and function are limited to bone marrow-derived cells. Here, we report the identification and characterization of p65BTK, a novel oncogenic …

it, dk (code pays fourni par la source)