Wilfrid Thabard

Protein kinase C δ and η isoenzymes control the shedding of the interleukin 6 receptor α in myeloma cells

Wilfrid Thabard, M. Collette, Régis Bataille, Martine Amiot

The soluble interleukin 6 receptor alpha is an agonistic molecule of interleukin 6 (IL-6) and is important in the biology of multiple myeloma. More precisely, it potentiates the deleterious effects of IL-6 during tumour progression, facilitating angiogenesis and bone resorption. Because the …

Protein kinase C δ and η isoenzymes control the shedding of the interleukin 6 receptor α in myeloma cells

Wilfrid Thabard, M. Collette, Régis Bataille, Martine Amiot

The soluble interleukin 6 receptor α is an agonistic molecule of interleukin 6 (IL-6) and is important in the biology of multiple myeloma. More precisely, it potentiates the deleterious effects of IL-6 during tumour progression, facilitating angiogenesis and bone resorption. Because the …

Interferon α extends the survival of human myeloma cells through an upregulation of the Mcl‐1 anti‐apoptotic molecule

Denis Puthier, Wilfrid Thabard, Marie‐José Rapp, Marguerite Etrillard et autres

We have recently reported that Mcl-1, an anti-apoptotic member of the Bcl-2 family, is upregulated by interleukin (IL)-6 in human myeloma cells through the janus kinase/signal transducers and activators of transduction (JAK/STAT) pathway. In the current study, we have explored the effects …

fr (code pays fourni par la source)

Pkc delta et myelome multiple : implications dans la generation du recepteur soluble a l'interleukine 6 et dans l'apoptose

Wilfrid Thabard

SOLUBLE IL-6Rα UPREGULATES IL-6, MMP-1 AND MMP-2 SECRETION IN BONE MARROW STROMAL CELLS

Sophie Barillé‐Nion, M. Collette, Wilfrid Thabard, Christophe Bleunven et autres

fr (code pays fourni par la source)

Myeloma cells release soluble interleukin-6Ralpha in relation to disease progression by two distinct mechanisms: alternative splicing and proteolytic cleavage.

Wilfrid Thabard, M Collette, Jean‐Luc Harousseau, M. Rapp et autres

Multiple myeloma (MM) is a plasma-cell malignancy characterized by the accumulation of malignant plasma cells within the bone marrow. Interleukin (IL)-6 is an essential survival and growth factor for myeloma cells that exerts its activity through a cell surface receptor composed of …

Tunisie (code pays fourni par la source)

CD130 rather than CD126 expression is associated with disease activity in multiple myeloma

Sophie Barillé‐Nion, Wilfrid Thabard, Nelly Robillard, Philippe Moreau et autres

We analysed the expression of both components of IL-6R, CD126 the ligand binding protein and CD130 the signal transducing protein, on plasma cells from MGUS and multiple myeloma (MM) cases using flow cytometry. CD126 was detectable in 50% of either MGUS or …

fr (code pays fourni par la source)