Connie W. Tsao

Relations of Menopause Timing With Pressure Pulsatility in the Framingham Study

Amy Y. Habib, Ross Okazaki, Brenton Prescott, Vanessa Xanthakis et autres

BACKGROUND: Women have lower pulse pressure (PP) than men as young adults, but higher PP after a midlife PP nadir. This PP reversal is often attributed to lower estrogen levels at menopause. However, a detailed analysis of hemodynamic changes around the time …

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Association of physical activity with arterial stiffness and pulsatility in a community-based cohort

Mawra Jha, Zhiyong Dong, Sean Meagher, Nicole L. Spartano et autres

Introduction: Central arterial stiffness and pressure pulsatility are key measures of arterial health and cardiovascular disease (CVD). Acute physical activity (PA) improves vascular function; however, its relationship with arterial health across varying habitual PA levels remains understudied. Methods: We analyzed Framingham Heart …

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Relations of Artificial Intelligence Vascular Age With Cardiometabolic Disease Progression: The Framingham Heart Study

David J. Hamel‐Sellman, Brenton Prescott, Timothy J. Korzinski, Vanessa Xanthakis et autres

BACKGROUND: Aortic stiffening increases pulsatile power transmission into the microvasculature, resulting in blunted microvascular reactivity, which can impair postprandial nutrient processing and glucose homeostasis. Cardiometabolic disease (CMD) contributes to aortic stiffening and risk for major cardiovascular disease events. Our goal was to …

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Abstract 4370414: Radiomics-Based Coronary Heart Disease Classification Using Cine Cardiac MRI in a Bi-Racial Cohort

Radhika Deshpande, Yi Meng, Kevin S. Peters, Ahmed Fahmy et autres

Introduction: Coronary heart disease (CHD) remains a leading global health burden. Cine cardiovascular magnetic resonance (CMR), the gold standard for evaluating left ventricular (LV) structure and function, avoids contrast but relies on human-derived clinical measures. Radiomics, a high-throughput image analysis method, offers …

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Abstract 4365000: Characterization of Plasma Proteins Associated with Arterial Stiffness and Pressure Pulsatility

Samir Zaman, Michelle J. Keyes, Emelia J. Benjamin, Mawra Jha et autres

Background: Stiffening of large arteries is a key pathophysiologic precursor of micro- and macrovascular disease. Increased arterial stiffness (AoS) and central pressure pulsatility (CPP) can precede the development of atherosclerosis, heart failure, cardiometabolic disease, and renal failure. Further research into the underlying …

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Abstract 4371213: Integrated Radiogenomics Improves Classification of Genetic Hypertrophic Cardiomyopathy

Ujwala Shenoy, Marcela Cuellar-Lobo, Lu Zhang, Radhika Deshpande et autres

Background: The prognosis of hypertrophic cardiomyopathy (HCM) varies by several factors, including imaging characteristics and genotype, reflecting underlying pathology. Traditional machine learning models typically require large datasets, which are challenging to obtain in rare disease research. Bayesian Networks (BN) excel with limited …

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Abstract 4364895: Automated External White Adipose Tissue Segmentation Using Routine Magnetic Resonance Imaging and Artificial Intelligence

Radhika Deshpande, Mawra Jha, Lu Zhang, Marcela Cuellar-Lobo et autres

Introduction: Quantifying adiposity, a key biomarker of metabolic health, typically requires imaging that involves radiation, high costs, and manual effort. We developed an AI framework to segment external white adipose tissue (EWAT) from routine non-contrast MRI, offering a radiation-free, low-effort alternative. Hypothesis: …

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Abstract 4368727: Characteristics and Prognosis of Non-Dilated Idiopathic Non-Ischemic Cardiomyopathy: A Distinct Clinical and Prognostic Entity

Marcela Cuellar-Lobo, Chidiogo Orizu, Elizabeth Király, Victoria Bothwick et autres

Backround: Idiopathic non-ischemic cardiomyopathy (iNICM) includes patients without identifiable causes of left ventricular systolic dysfunction. While dilated cardiomyopathy (DCM) has been extensively studied, the entity of non-dilated iNICM remains poorly understood. Methods: We retrospectively identified 197 consecutive patients with AHA/ACC Stage B …

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Abstract 4362048: Relationship between menopause timing and age-associated pulse pressure widening in the Framingham Heart Study

Ross Okazaki, Brenton Prescott, Vanessa Xanthakis, Leroy L. Cooper et autres

Background and Research Question: Increasing pulse pressure (PP) occurs with aging and is a risk factor for CVD. PP is shown to fall to a nadir in midlife with subsequent increase with age thereafter. This increase is notably sharper in women compared …

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Epicardial adipose tissue: When good fat goes bad

Jamey Cutts, Connie W. Tsao, Amit R. Patel

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Relations of AI-Vascular Age Estimated From a Peripheral Pressure Waveform With Incident Atrial Fibrillation: The Framingham Heart Study

Timothy J. Korzinski, Celestin Hategeka, Brenton Prescott, David J. Hamel‐Sellman et autres

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Associations of cardiovascular health with arterial health in adults free of cardiovascular disease

Mawra Jha, Zhiyong Dong, Maria Ruda, Brenton Prescott et autres

Background: In adults without cardiovascular disease (CVD), there is limited understanding of the association between overall cardiovascular health (CVH) and arterial health. Methods: In 2330 Framingham Heart Study Offspring participants free of CVD (60±9 years; 57% women) with Life's Essential 8 (LE8) …

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