Katherine B. Case

Racial differences in mycosis fungoides and Sézary syndrome: A multicenter cohort study

Pamela B. Allen, Subir Goyal, Swaminathan P. Iyer, Sai M. Talluru et autres

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Black patients with cutaneous T-cell lymphoma (CTCL) and their likelihood to receive novel agents: A retrospective cohort analysis.

Katherine B. Case, Angelo Alessandro Marra, Jeffrey M. Switchenko, Darina Paulino et autres

e13822 Background: Black patients with cutaneous T-cell lymphoma (CTCL) have increased risk of mortality compared to other racial groups. The introduction of novel therapies such as mogamulizumab and brentuximab vedotin (BV) for the treatment of CTCL have demonstrated improved survival compared to …

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Advances in Novel Systemic Therapies for the Management of Cutaneous T Cell Lymphoma (CTCL)

Katherine B. Case, Pamela B. Allen

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Trop-2 and Ephrin B2 expression in urothelial carcinoma with divergent differentiation and aggressive urothelial carcinoma subtypes

Katherine B. Case, Dylan J. Martini, Melad Dababneh, Samuel Bidot et autres

OBJECTIVES: Urothelial carcinomas (UCs) encompass a heterogeneous group of tumors. Several histopathologic features are associated with poor clinical outcomes and limited treatment options. With new rising therapeutic modalities, we aimed to determine the pattern of expression of Trop-2 and ephrin B2 in …

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Real-World Outcomes in Patients with Advanced Penile Squamous Cell Carcinoma Receiving Immune Checkpoint Inhibitors: A Single Institution Experience

Tony Zhuang, Subir Goyal, Katherine B. Case, T. Anders Olsen et autres

Introduction Advanced penile squamous cell carcinoma (pSCC) is a rare and aggressive malignancy with a poor prognosis and an unmet need for biomarkers. We performed a retrospective evaluation of real-world efficacy, safety outcomes, and baseline inflammatory biomarkers in patients with advanced pSCC …

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PD‐L1 and nectin‐4 expression and genomic characterization of bladder cancer with divergent differentiation

Dylan J. Martini, Katherine B. Case, Derrik Gratz, Kathryn L. Pellegrini et autres

BACKGROUND: Bladder cancer with divergent differentiation (BCDD) comprises a heterogenous group of tumors with a poor prognosis, and differential expression of nectin-4 and programmed death ligand-1 (PD-L1) has been reported in BCDD. Importantly, nectin-4 expression in bladder cancer is associated with response …

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Racial differences in therapies received by patients with cutaneous T cell lymphoma (CTCL): A single center retrospective cohort analysis.

Katherine B. Case, Angelo Alessandro Marra, Jeffrey M. Switchenko, Darina Paulino et autres

e23141 Background: Black patients with cutaneous T-cell lymphoma (CTCL) have increased risk of mortality and higher rates of treatment complications compared to other racial groups, however, drivers of these disparities are poorly understood. Recent advances in novel targeted therapies, such as mogamulizumab …

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Barriers and Facilitators Affecting Long-Term Antibiotic Prescriptions for Acne Treatment

Ronnie Festok, Avni S. Ahuja, Jared Y. Chen, Lena Chu et autres

Importance: Dermatologists prescribe more oral antibiotics per clinician than clinicians in any other specialty. Despite clinical guidelines that recommend limitation of long-term oral antibiotic treatments for acne to less than 3 months, there is little evidence to guide the design and implementation …

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Genetic Profiling of African American Patients With Prostatic Adenocarcinoma Metastatic to the Lymph Nodes: A Pilot Study

Samuel Bidot, Jun Jie Yin, Pengbo Zhou, Linsheng Zhang et autres

CONTEXT.—: Genetic profiling data of prostatic adenocarcinoma are derived from predominantly White patients. In African Americans, prostatic adenocarcinoma has a poorer prognosis, raising the possibility of distinct genetic alterations. OBJECTIVE.—: To investigate the genomic alterations of prostatic adenocarcinoma metastatic to regional lymph …

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Investigating the impact of demographic disparities on clinical outcomes in cutaneous T-cell lymphoma (CTCL): A multicenter retrospective cohort analysis.

Tim Niyogusaba, Jeffrey M. Switchenko, Sima Rozati, Swaminathan P. Iyer et autres

7573 Background: Black patients have been shown to have a higher incidence of cutaneous T-cell lymphomas (CTCL) and display unique clinicopathologic features at diagnosis, however, drivers of these disparities and the role of social determinants of health (SDoH) remain poorly understood. Methods: …

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Metastatic Clear-Cell Renal Cell Carcinoma in the Era of Immune Checkpoint Inhibitors: Therapies and Ongoing Trials

Tony Zhuang, Katherine B. Case, T. Anders Olsen, Jacqueline Theresa Brown et autres

Immune checkpoint inhibitors (ICI) are now the bedrock for the treatment of metastatic renal cell carcinoma (RCC). Clear cell RCC (ccRCC) represents the most common subtype of this malignancy. Herein, we explore the therapeutic landscape of ccRCC by discussing the standard of …

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Expression of Nectin-4 and PD-L1 in bladder cancer with variant histology.

Katherine B. Case, Dylan J. Martini, Melad Dababneh, Bassel Nazha et autres

529 Background: Nectin-4, a cell adhesion molecule found in a frequently amplified region of the bladder cancer (BC) genome, has been recently used as target for the systemic treatment of locally advanced or metastatic BC. BC with variant histology (BCVH) is associated …

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