Abstract B208: Targeting ITGA5 in pancreatic stellate cells as a novel strategy to restrain pancreatic tumor growth
Praneeth Reddy Kuninty, Sanne de Geus, Ruchi Bansal, Jonas Schnittert et autres
Abstract Pancreatic ductal adenocarcinoma (PDAC) is the deadliest tumor type with a 5-year survival rate of less than 5%. PDAC is characterized by abundant desmoplastic stroma, driving tumor progression and metastasis. Cancer-associated fibroblasts (CAFs) are the key pro-tumorigenic stromal cells in pancreatic …
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Molecular Cancer Therapeutics