Rebecca Piccarducci

Editorial: New horizons in Alzheimer's disease research: combining cell, gene, and emerging therapies

Rebecca Piccarducci, Marco Mainardi, Laura Marchetti

conventional molecular approaches. Reflecting this broader translational perspective, Galeotti and collaborators investigate the use of low mechanical stimulation to counteract cytoskeletal and neuritic damage in cellular models of AD and related tauopathies. By demonstrating that mechanical stimulation can prevent axonal growth impairment …

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Fluid biomarkers in cerebral amyloid angiopathy: current limitations and future directions

Marta Del Chicca, Gaia Mignani, Fabio Iannaccone, Rebecca Piccarducci et autres

INTRODUCTION: Cerebral amyloid angiopathy (CAA) is a major cause of lobar intracerebral hemorrhage and cognitive decline in older adults. Current diagnosis relies mainly on neuroimaging, which lacks pathophysiological specificity. AREAS COVERED: This narrative review summarizes evidence on cerebrospinal fluid (CSF) and plasma …

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Recent advances in the development of selective hMAO-B inhibitors for neurodegenerative diseases: An update from 2020 to present

Silvia Salerno, Giovanni Fabbri, Maria Luisa Di Paolo, Francesco Piazzola et autres

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Mild Cognitive Impairment Associated with Obstructive Sleep Apnoea: A Pilot Study on Oxygen-Related Plasma Biomarkers and Network Analysis

Martina De Felice, Alessia Pascazio, Rebecca Piccarducci, Lorenzo Germelli et autres

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Corrigendum to “Microfluidic-assisted erythrocyte-membrane camouflaged chitosan nanoparticles for nucleic acid delivery” [J. Drug Deliv. Sci. Technol. 115 Part 1 (2026) 107699]

Chiara Migone, Angela Fabiano, Ylenia Zambito, Marta Toigo et autres

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Microfluidic-assisted erythrocyte-membrane camouflaged chitosan nanoparticles for nucleic acid delivery

Chiara Migone, Angela Fabiano, Ylenia Zambito, Marta Toigo et autres

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Extracellular vesicles as vehicles for small non-coding RNA therapeutics: standardization challenges for clinical translation

Lucrezia Luisotti, Lorenzo Germelli, Rebecca Piccarducci, Chiara Giacomelli et autres

Aim: Extracellular vesicles (EVs) have emerged as promising vehicles for the delivery of small non-coding RNAs (sncRNAs); however, their clinical translation is hindered by the lack of standardized manufacturing methods, RNA loading protocols, and dosing strategies in both preclinical and clinical settings. …

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AR-A014418-based dual Glycogen Synthase Kinase 3β/Histone Deacetylase inhibitors as potential therapeutics for Alzheimer's disease

Alan Santini, Elisa Tassinari, Alessandra Altomare, Manuela Loi et autres

Alzheimer's disease (AD), the most common type of dementia, currently represents an unmet medical need worldwide. It is considered the result of a systemic breakdown of multiple physiological networks which might be adequately tackled by multitarget drugs (MTDs) aimed at restoring the …

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Linear DNA–Chitosan Nanoparticles: Formulation Challenges and Transfection Efficiency in Lung Cell Line

Chiara Migone, Angela Fabiano, Ylenia Zambito, Rebecca Piccarducci et autres

Linear DNA constructs are used in gene delivery and therapy application due to their capacity of integration into the mammalian genome, offering stable transgene expression. Compared to circular plasmids, linear DNA also has the advantage that its dimension and steric hindrance are …

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Serum Lactate Dehydrogenase Levels Reflect the Lung Injury Extension in COVID‐19 Patients at Hospital Admission

Maria Sofia Bertilacchi, Giulia Vannucci, Rebecca Piccarducci, Lorenzo Germelli et autres

BACKGROUND: Several hematological and biochemical parameters have been related to the COVID-19 infection severity and outcomes. However, less is known about clinical indicators reflecting lung involvement of COVID-19 patients at hospital admission. Computed tomography (CT) represents an established imaging tool for the …

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Ar-A014418-Based Dual Glycogen Synthase Kinase 3β / Histone Deacetylases Inhibitors as Potential Therapeutics for Alzheimer's Disease

Alan Santini, Elisa Tassinari, Alessandra Altomare, Manuela Loi et autres

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GFP Farnesylation as a Suitable Strategy for Selectively Tagging Exosomes

Rebecca Piccarducci, Lorenzo Germelli, Alessandra Falleni, Lucrezia Luisotti et autres

Exosomes are small extracellular vesicles (EVs) constituting fully biological, cell-derived nanovesicles with great potential in cell-to-cell communication and drug delivery applications. The current gold standard for EV labeling and tracking is represented by fluorescent lipophilic dyes which, however, importantly lack selectivity, due …

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