Qun Ji

Early prediction of gestational diabetes mellitus using machine learning-integrated metabolomic and clinical features

Qun Ji, Lan Gao, Haiwei Liu, Xiaofang Chen et autres

Background: Gestational diabetes mellitus (GDM), a prevalent metabolic disorder associated with pregnancy, which often postpones intervention until after metabolic complications have developed. This study seeks to develop an integrated predictive model that combines first trimester metabolomic signatures with established clinical risk factors …

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Combined transcriptome and microbiome characterization highlights digestive system development involved in the metabolism and immunity of the large yellow croaker (Larimichthys crocea)

Zhiyi Bai, Hao Xu, Qun Ji, Wei Song

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Analysis of the etiological characteristics of multidrug-resistant organisms and prognostic factors in ICU patients

Fengxia Du, Qun Ji, Ying Li, Jing Jia et autres

Background Multidrug-resistant organism (MDRO) infections contribute to high mortality in intensive care unit (ICU) patients, yet their specific pathogen profile and mortality risk factors are inadequately characterized. Objective In this study, we aim to investigate MDRO infections in ICU patients, identify prevalent …

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Hydrogen sulfide and ferroptosis inhibition underlies the dietary restriction-induced protection against cyclophosphamide cystitis

Zhimin Mao, Ping Chen, Qun Ji, Kun Zhong et autres

Dietary restriction (DR) has emerged as a potential therapeutic intervention for various pathological conditions. This study investigated the effects of DR on cyclophosphamide-induced cystitis in mice. Animals were subjected to controlled food restriction for 1 week prior to cyclophosphamide administration. We evaluated …

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Phage Display Isolation of VHH Antibodies Targeting Capsular Polysaccharides of Intratumor Bacteria

Qun Ji, Oren Moscovitz

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Hydrogen sulfide protects against toxicant acrolein-induced ferroptotic cell death in Sertoli cells

Zhimin Mao, Qun Ji, Ping Chen, Kun Zhong et autres

Acrolein (ACR) is a ubiquitous environmental pollutant and byproduct of lipid peroxidation that has been implicated in male infertility. However, the molecular mechanisms underlying ACR-induced toxicity in Sertoli cells remain unclear. Given its role in inducing oxidative stress, we examined whether ferroptosis, …

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Progression of gestational diabetes mellitus to pregnancy-associated fulminant type 1 diabetes: a case report

Qun Ji, Haiwei Liu, Fei Wang, Lan Gao et autres

Background: Pregnancy-associated fulminant type 1 diabetes (PF) occurs during pregnancy or within 2 weeks of delivery. Although it occurs infrequently, it is associated with high fetal mortality rate. Few studies have examined whether PF is associated with gestational diabetes mellitus (GDM). Case …

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Ghrelin regulates the endoplasmic reticulum stress signalling pathway in gestational diabetes mellitus

Xinying Li, Qun Ji, Chunrong Zhong, Congyin Wu et autres

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A Characterization of the RNA Modification Response to Starvation under Low Temperatures in Large Yellow Croaker (Larimichthys crocea)

Qun Ji, Zhengli Xie, Li-Zhen Li, Xulei Han et autres

Emerging evidence shows that N6-methyladenosine (m6A) is a post-transcriptional RNA modification that plays a vital role in regulation of gene expression, fundamental biological processes, and physiological functions. To explore the effect of starvation on m6A methylation modification in the liver of Larimichthys …

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Effect and Predictive Value of Blood HbA1c, FBG, 2hPBG, and FINS on the Pregnancy Outcome in Patients with Gestational Diabetes Mellitus

Haiwei Liu, Lan Guo, Fei Wang, Qun Ji et autres

BACKGROUND: This study aimed to investigate the effects of hemoglobin A1c (HbA1c), fasting blood glucose (FBG), 2-hours postprandial blood glucose (2hPBG), and fasting insulin (FINS) levels on pregnancy outcomes and their predictive value in patients with gestational diabetes mellitus (GDM). METHODS: A …

Exploring the clinical significance of miR‐148 expression variations in distinct subtypes of irritable bowel syndrome

Qun Ji, Fengxia Du, Yangyaxin Yu, Ying Li

Irritable bowel syndrome (IBS) belongs to chronic functional gastrointestinal diseases featured by abdominal pain and changes in bowel habits. This study aimed to investigate the clinical significance of serum miR-148 expression in different subtypes of IBS. We enrolled 86 IBS patients and …

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Periostin Acts as a Bridge between Gestational Diabetes Mellitus (GDM) and Chronic Inflammation to Modulate Insulin Resistance by Modulating PPARα/NF-κB/TNF-α Signaling Pathway

Qun Ji, Xinying Li, Yan Wang, Haiwei Liu et autres

INTRODUCTION: Gestational diabetes mellitus (GDM) is considered an imbalance of glucose metabolism and insulin resistance during pregnancy. AIMS/OBJECTIVE: To evaluate the levels of periostin (POSTN) in patients with GDM and investigate the association between POSTN and GDM. MATERIALS AND METHODS: A total …

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