Richard Nuccitelli

Is Deficiency in the Electrical Current of Injury a Barrier to Healing in Hard-to-Heal Wounds? A Systematic Review with Implications for the TIMERS Paradigm

Jenny Smith, Richard Nuccitelli, Min Zhao, Leanne Atkin et autres

OBJECTIVES: Endogenous bioelectric signaling (including transepidermal potential [TEP] and the current of injury) plays a fundamental role in normal wound repair. Despite this, commonly used wound management frameworks do not consider this important driver of healing. The objectives of this review are …

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First-in-Human Clinical Feasibility Study of Ablation of Benign Thyroid Nodules Using Nanosecond Pulsed Field Ablation

Stefano Spiezia, Chiara Offi, Claudia Misso, Giovanni Antonelli et autres

Background: Thyroid nodules are common in the general population, and most are benign. Thyroidectomy remains the most common treatment for symptomatic benign thyroid nodular disease. The objective of this study is to determine if a novel, cell-specific, nonthermal modality called nanosecond pulsed …

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Nanosecond Pulsed Field Ablation in Oncology

Richard Nuccitelli

Cancer therapy has evolved significantly over the past three decades and this review focuses on some of the new ablation modalities that have been developed as well as the importance of combination therapies which enlist the immune system. During the late 1990’s …

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Nano-Pulse Stimulation Therapy in Oncology

Richard Nuccitelli, Amanda E. McDaniel

Background: Nano-Pulse Stimulation (NPS) therapy applies electric pulses in the nanosecond domain to initiate regulated cell death in the treated tissues. This nonthermal therapy has been used to treat a wide range of murine tumors and has been shown to activate the …

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The CellFX Percutaneous Electrode System for Nanosecond Pulsed Field Ablation

Richard Nuccitelli, Jeffrey S. Litt, KEVIN L. MOSS, Dale Hinman et autres

The purpose of this study was to demonstrate the safety and performance of the CellFX Percutaneous Electrode for delivering nanosecond pulsed field ablation (nsPFA) energy to soft tissues. Three different porcine tissue types were treated, namely, liver, kidney, and skeletal muscle, at …

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Nano-Pulse Stimulation Therapy Initiates Regulated Cell Death in Skin, Unlike Bovie Radiofrequency Ablation and Cryoablation

Richard Nuccitelli, Michelle Martínez, David Ross Kaufman, Darius R. Mehregan et autres

Background: This study describes a unique new bioelectric approach for clearing skin lesions and illustrates the clinical and histological differences between this new method and the standards of cryoablation and Bovie ® radiofrequency ablation (RFA). Objectives: To determine the advantage of stimulating …

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Nano-Pulse Stimulation Treatment Inhibits Pan02 Murine Pancreatic Tumor Growth and Induces a Long-Term Adaptive Immune Response with Abscopal Effects When Combined with Immune-Enhancing Agents

Amanda E. McDaniel, Kristin Von Rothstein, Dacia Gonzalez, Richard Nuccitelli

Pancreatic cancer is associated with a poor prognosis and immunotherapy alone has not demonstrated sufficient efficacy in the treatment of nonresectable tumors. Nano-Pulse Stimulation™ therapy (NPS™) applies nanosecond electric pulses that lead to regulated cell death, exposing tumor antigen to the immune …

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Introduction to This Special Issue: Biomedical Applications of Pulsed Electric Fields

Richard Nuccitelli

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Discoveries in Travels from Nanovolts to Kilovolts

Richard Nuccitelli

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Nano-pulse stimulation™ therapy (NPS™) is superior to cryoablation in clearing murine melanoma tumors

Amanda E. McDaniel, Bruce D. Freimark, Cebrina Navarro, Kristin Von Rothstein et autres

Background: Nano-Pulse Stimulation™ Therapy (NPS™) is a new, bioelectric modality that applies ultrashort pulses of electric energy to trigger regulated cell death in treated tissues. Instead of initiating necrosis by heating or freezing, NPS therapy permeabilizes intracellular organelles to activate the cell's …

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Safety and effectiveness of nano‐pulse stimulation™ technology to treat acne vulgaris of the back

Bruce Katz, Mark S. Nestor, Richard Nuccitelli, Lauren Jauregui Johnston et autres

BACKGROUND AND OBJECTIVES: This feasibility study describes the effects of Nano-pulse stimulation™ (NPS™) technology using the CellFX™ System on acne vulgaris of the back with the objectives of demonstrating safety and effectiveness. The CellFX System applies nanosecond pulses of electrical energy to …

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Multicenter, prospective feasibility study of Nano-Pulse Stimulation™ technology for the treatment of both nodular and superficial low-risk basal cell carcinoma

AMY SIMON ROSS, Todd E. Schlesinger, Christopher B. Harmon, Ronald L. Moy et autres

Background Nano-Pulse Stimulation™ (NPS™) therapy is a new, non-thermal bioelectric modality that applies ultrashort pulses of electric energy to trigger regulated cell death (RCD) in treated tissues. Instead of initiating necrosis by heating or freezing, NPS therapy permeabilizes intracellular organelles to activate …

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