Bohdana Hurieva

Bacterial defense via RES-mediated NAD+ depletion is countered by phage phosphatases

Ilya Osterman, Bohdana Hurieva, Erez Yirmiya, Azita Leavitt et autres

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Conserved catalytic activity of immune TIR domains in animals

Bohdana Hurieva, Ilya А. Osterman, Alla H. Falkovich, Erez Yirmiya et autres

Abstract The Toll/interleukin-1 receptor (TIR) domain is important for immune signaling across bacteria, plants, and animals. In human innate immunity, TIR domains are known to function as adaptors mediating protein-protein interactions, yet studies in bacteria and plants revealed that TIR domains often …

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Engineering intrinsically disordered regions for guiding genome navigation

Jing Liu, Divya Krishna Kumar, Bohdana Hurieva, Felix Jonas et autres

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Bacterial defense via RES-mediated NAD + depletion is countered by phage phosphatases

Ilya А. Osterman, Bohdana Hurieva, Erez Yirmiya, Dina Hochhauser et autres

Abstract Many bacterial defense systems restrict phage infection by breaking the molecule NAD + to its constituents, adenosine diphosphate ribose (ADPR) and nicotinamide (Nam). To counter NAD + depletion-mediated defense, phages evolved NAD + reconstitution pathway 1 (NARP1), which uses ADPR and …

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Disordered sequences of transcription factors regulate genomic binding by integrating diverse sequence grammars and interaction types

Bohdana Hurieva, Divya Krishna Kumar, R. Graham Morag, Offir Lupo et autres

Intrinsically disordered regions (IDRs) guide transcription factors (TFs) to their genomic binding sites, raising the question of how structure-lacking regions encode for complex binding patterns. We investigated this using the TF Gln3, revealing sets of IDR-embedded determinants that direct Gln3 binding to …

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Cell cycle status of male and female gametes during Arabidopsis reproduction

Yoav Voichek, Bohdana Hurieva, Caroline Michaud, Anna Schmücker et autres

Fertilization in Arabidopsis (Arabidopsis thaliana) is a highly coordinated process that begins with a pollen tube delivering the 2 sperm cells into the embryo sac. Each sperm cell can then fertilize either the egg or the central cell to initiate embryo or …

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Cell-cycle status of male and female gametes during Arabidopsis reproduction

Yoav Voichek, Bohdana Hurieva, Caroline Michaud, Anna Schmücker et autres

Abstract Fertilization in Arabidopsis thaliana is a highly coordinated process that begins with a pollen tube delivering the two sperm cells into the embryo sac. Each sperm cell can then fertilize either the egg or the central cell to initiate embryo or …

at, fr, es, de (code pays fourni par la source)