Accès ouvert
2026
article
OpenAlex
Alessio Daniele, Samuel J. E. Lucas, Catarina Rendeiro
< 0.001). Flavanols had no effect on the muscle microvasculature. These findings indicate that flavanol-rich foods may be efficacious nutritional strategies to counteract sitting-induced endothelial impairments during prolonged sitting in older adults, but do not alleviate sitting-induced increases in BP.
gb
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Accès ouvert
2025
article
OpenAlex
Daniel D. Hodgkiss, Shane J. T. Balthazaar, Cameron M. Gee, Shin‐Yi Chiou et autres
BACKGROUND: Spinal cord injury (SCI) affects motor and autonomic functions that reduce exercise capacity. Specifically, the loss of sympathetic drive following SCI at or above the sixth thoracic segment (≥ T6) can impair cardiovascular responses to exercise. This systematic scoping review aimed …
gb, ca
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Accès ouvert
2025
review
OpenAlex
Ben S. Price, Samuel J. E. Lucas, Ashley Paul Akerman, Rachel E. Gilworth et autres
Abstract Heat thermotherapy (HT) is reported to promote cardiovascular (CV) and cardiometabolic health benefits. This systematic review and meta‐analysis (CRD42020193669) empirically investigated the efficacy of HT in improving CV and cardiometabolic parameters by assessing responses to single versus multiple HT bouts. Databases …
gb
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Accès ouvert
2025
article
OpenAlex
Alessio Daniele, Samuel J. E. Lucas, Catarina Rendeiro
Sedentary behaviour is very prevalent in modern societies, with young adults spending approximately 6 h/day sitting. Sitting induces declines in endothelial function, increasing the risk of cardiovascular diseases. Nutrition during sitting may be used as a strategy to minimise such effects. This …
gb
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Accès ouvert
2025
article
OpenAlex
Shahrzad Soleimani Dehnavi, Jonathan D. Smirl, Marc‐Antoine Roy, Lawrence Labrecque et autres
Cerebral blood flow changes are buffered when blood pressure increases versus decreases. The current findings suggest that acute exposure and partial acclimatization to high altitude do not influence the presence of this phenomenon in lowlanders. Preservation of this hysteresis-like pattern across all …
ca, gb
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Accès ouvert
2025
article
OpenAlex
Foyzul Rahman, Kamen A. Tsvetanov, J.-M. Féron, Karen J. Mullinger et autres
Cognitive decline associated with healthy ageing is multifactorial: brain-based and lifestyle factors uniquely and jointly contribute to distinct neurocognitive trajectories of ageing. To evaluate existing models of neurocognitive ageing such as compensation, maintenance, or reserve, we explore how various known brain-based and …
gb, no
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Accès ouvert
2025
article
OpenAlex
Alessio Daniele, Samuel J. E. Lucas, Catarina Rendeiro
Background: Sitting is highly prevalent among young and older adults and can transiently reduce cerebral blood flow. Dietary flavanols confer benefits to the peripheral vasculature and may be effective at counteracting the impact of sitting in the cerebrovasculature. The aim of this …
gb
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Accès ouvert
2025
review
OpenAlex
Arsalan Moinuddin, Craig A. Paterson, Louise A. Turner, Keeron J. Stone et autres
Introduction: Sedentary behavior, specifically an acute bout of prolonged uninterrupted sitting, is associated with heightened cardiovascular disease (CVD) risk, with increased arterial stiffness (AS) being implicated as a principal pathophysiological mechanism. The current systematic review, with meta-analysis, aimed to consolidate the AS …
gb
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Accès ouvert
2025
article
OpenAlex
Rachel E. Gilworth, Bethany D. Skinner, Daniel D. Hodgkiss, Samuel J. E. Lucas et autres
Increasing numbers of females are performing in increasingly hot environments. This scoping review aimed to 1) collate evidence on the effects of environmental heat stress on aerobic exercise performance and work productivity in females specifically, and 2) explore sex differences in the …
gb
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Accès ouvert
2025
article
OpenAlex
Roberto Salgado, A. Bardia, G. Curigliano, Xichun Hu et autres
BACKGROUND: The DESTINY-Breast06 study demonstrated a statistically significant and clinically meaningful improvement in progression-free survival benefit with trastuzumab deruxtecan (T-DXd) versus chemotherapy treatment of physician's choice in patients with hormone receptor-positive metastatic breast cancer (mBC) whose tumors were scored as human epidermal …
sg, au, us, it, cn, fr, jp, be, ch, pl, es
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Accès ouvert
2025
article
OpenAlex
Felicity S. E. Spencer, Richard J. Elsworthy, Leigh Breen, Jonathan R. B. Bishop et autres
Brain-derived neurotrophic factor (BDNF) and secreted amyloid precursor protein-alpha (sAPPα) promote neuronal growth but are lower in people with Alzheimer's Disease (AD). BDNF increases after exercise, but the response may vary with exercise intensity and across blood fractions. While sAPPα rises post-exercise …
gb
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Accès ouvert
2025
article
OpenAlex
Alex J. Wadley, Fendi Pradana, Tarondeep Nijjar, Mark Trehane Drayson et autres
Peripheral blood stem cell (PBSC) donation is the primary procedure used to collect haemopoietic stem cells (HSCs) for transplantation in individuals with haematological malignancies. More than 90,000 HSC transplants take place globally each year, and there is an increasing need to guarantee …
gb, id
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