Qun Yi

Research progress on precision targeted therapy strategies for breast cancer based on tumor microenvironment

罗云波, Panlin Xie, Shaokang Yang, Peng Qu et autres

The tumor microenvironment (TME) plays a crucial role in the progression of BC, characterized by abnormal pH, aberrant enzyme expression, redox imbalance, etc. Nano-drug delivery systems (NDDSs) responsive to TME have emerged, including pH-responsive, enzyme-responsive, redox-responsive, and multi-responsive intelligent cascading systems. These …

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The impact of systemic corticosteroids guided by blood eosinophil thresholds and rome classification on clinical outcomes in hospitalized AECOPD patients: a multicenter study

Jiaqi Pu, Mingjing Yu, Yuanming Luo, Hailong Wei et autres

This study assessed the efficacy of combining blood eosinophil (EOS) thresholds and Rome classification to guide corticosteroid therapy in hospitalized acute exacerbations of chronic obstructive pulmonary disease (AECOPD) patients. This multicenter study analyzed data from 7 to 111 AECOPD patients, stratified by …

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Breast Cancer-Associated Venous Thromboembolism: Risk Factors, Mechanisms, and Clinical Management

Panlin Xie, Yunbo Luo, Lingmi Hou, Jia Xu et autres

Venous thromboembolism (VTE) is a clinically significant complication in patients with breast cancer (BC) and may disrupt treatment continuity while contributing to adverse outcomes. Although BC is generally regarded as a relatively low-risk malignancy for VTE compared with several other cancer types, …

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Limited predictive value of Padua and Caprini scores for venous thromboembolism in AECOPD patients with atrial fibrillation

Jiaqi Pu, Yuanming Luo, Hailong Wei, Huiqing Ge et autres

Venous thromboembolism (VTE) risk is elevated in acute exacerbations of COPD (AECOPD), especially with coexisting atrial fibrillation (AF). However, the Caprini and Padua scores, validated in surgical or general medical populations, may not capture thrombotic risk in AECOPD-AF patients, and their predictive …

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Comprehensive circRNA profiling of platelets and exosomes identifies hsa_circ_0061274 as a novel biomarker for lung adenocarcinoma

Peiyin Zhang, Shan Liu, B T Hu, Ping Leng et autres

Background: Lung adenocarcinoma (LUAD) is usually detected late; sensitive, minimally invasive early-detection tools are urgently needed. Circular RNAs (circRNAs) in liquid biopsies are promising cancer biomarkers, yet it remains unclear which blood component-platelets or plasma exosomes-offers the richest and most informative circRNA …

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Supplementary Table S5 from Large-Scale T-cell Receptor Repertoire Profiling Unveils Tumor-Specific Signals for Diagnosing Indeterminate Pulmonary Nodules

Huaichao Luo, Wei Guo, Xinyu Luan, Tao Yue et autres

Evaluate multiple model performance

Supplementary Figure S8 from Large-Scale T-cell Receptor Repertoire Profiling Unveils Tumor-Specific Signals for Diagnosing Indeterminate Pulmonary Nodules

Huaichao Luo, Wei Guo, Xinyu Luan, Tao Yue et autres

Biology and Disease Annotation of Enriched CDR3-beta aaSeqs

Supplementary Table S2 from Large-Scale T-cell Receptor Repertoire Profiling Unveils Tumor-Specific Signals for Diagnosing Indeterminate Pulmonary Nodules

Huaichao Luo, Wei Guo, Xinyu Luan, Tao Yue et autres

Identify lung cancer-enriched TCR sequences

Supplementary Table S1 from Large-Scale T-cell Receptor Repertoire Profiling Unveils Tumor-Specific Signals for Diagnosing Indeterminate Pulmonary Nodules

Huaichao Luo, Wei Guo, Xinyu Luan, Tao Yue et autres

Clinical and TCR characteristics for LungTCR database

Supplementary Table S3 from Large-Scale T-cell Receptor Repertoire Profiling Unveils Tumor-Specific Signals for Diagnosing Indeterminate Pulmonary Nodules

Huaichao Luo, Wei Guo, Xinyu Luan, Tao Yue et autres

Clinical and TCR characteristics for patients with indeterminate pulmonary nodules

Supplementary Figure S4 from Large-Scale T-cell Receptor Repertoire Profiling Unveils Tumor-Specific Signals for Diagnosing Indeterminate Pulmonary Nodules

Huaichao Luo, Wei Guo, Xinyu Luan, Tao Yue et autres

Evaluation and external validation of lung cancer-enriched TCR sequences

Supplementary Figure S6 from Large-Scale T-cell Receptor Repertoire Profiling Unveils Tumor-Specific Signals for Diagnosing Indeterminate Pulmonary Nodules

Huaichao Luo, Wei Guo, Xinyu Luan, Tao Yue et autres

Evaluation of confounding factors and the analysis of clinical applicability for the TCRnodseek plus model