Han Wu

Surface-Engineered Phytochemical Nanomedicines for Postmenopausal Osteoporosis: Skeletal Targeting, Imaging-Supported Evaluation, and Therapeutic Performance

Hongwei Gao, Shaorong Li, Han Wu, Weijian Wang et autres

Postmenopausal osteoporosis (PMOP) is a metabolic bone disease driven by estrogen deficiency and a major contributor to fragility fractures, yet long-term use of current antiresorptive and anabolic agents remains constrained by tolerability and adherence. Plant-derived bioactive compounds—including flavonoids, isoflavones, curcuminoids, and stilbenes—show …

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Corrigendum to “Fractionated Dosing of High-Dose Vitamin C Sustains Higher Plasma Trough Concentrations in Advanced Solid Tumors: A Phase I Clinical Study” [Translational Oncology, 2026, 71, 102834]

Qing Yin, You Wang, Han Wu, Qingqing Wang et autres

This was a single-center, open-label, phase I clinical trial conducted at *****

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Structure-based redesign enables clinical translation of CAIX-targeted theranostics in clear cell renal cell carcinoma

Zexin Xu, Hui Zhou, Dong Ye, Dan Feng et autres

Carbonic anhydrase IX (CAIX) is an interesting therapeutic target in clear cell renal cell carcinoma (ccRCC), but gastrointestinal uptake impedes the clinical translation of CAIX-targeted radioligand.In this study, structure-guided optimization of a cyclic peptide scaffold was conducted to decouple tumor targeting from …

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Fractionated high-dose vitamin c sustains higher plasma trough concentrations in advanced solid tumors: a phase I clinical study

Qing Yin, You Wang, Han Wu, Qingqing Wang et autres

High-dose vitamin C (HDVC) has a short half‑life of approximately 2 h, and once‑daily dosing results in sub‑therapeutic plasma concentrations for most of the dosing interval, potentially limiting its pro‑oxidant antitumor activity. In this phase I study, 18 patients with advanced solid …

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Cumulative live birth after unstimulated in vitro maturation versus conventional in vitro fertilization (IVF) in women with polycystic ovary syndrome: a 36-month retrospective matched cohort study

Wei Guo, Lixue Chen, Zi Yang, Linlin Wang et autres

BACKGROUND: Polycystic ovary syndrome (PCOS) is characterized by heterogeneous ovarian responsiveness and a heightened risk of ovarian hyperstimulation syndrome (OHSS) during gonadotropin stimulation. Strictly unstimulated in vitro maturation (IVM) avoids ovarian stimulation and may reduce treatment burden; however, long-term cumulative live birth …

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Recalibrating the evidence level in hepatocellular carcinoma: Integrating efficacy and effectiveness of immunotherapy

Han Wu, Xin‐Fei Xu, Jia Hao Law, Tian Yang

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Influence of neoadjuvant immunotherapy on surgical approaches in non-small cell lung cancer: insights from a Chinese Expert Questionnaire Survey on Contemporary Practices

Han Wu, Long Jiang, Jiantao Li, Jia Huang et autres

Background: The extent to which neoadjuvant immunotherapy may complicate subsequent surgical procedures in selected cases of non-small cell lung cancer (NSCLC) is yet to be definitively established. This study was designed to explore the influence of neoadjuvant immunotherapy on the practical surgical …

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Development and Validation of an Individualized Prediction Model for Postoperative Late Recurrence After Hepatectomy for Hepatocellular Carcinoma (POLAR-HCC): A Multicenter Study

Xin‐Fei Xu, Han Wu, Li‐Hui Gu, Yu-Ze Zhao et autres

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Effect of microscope-assisted modified lateral lumbar interbody fusion and impact on lumbar lordosis and intervertebral height

Weijian Wang, Jilong An, Jiaqi Li, Han Wu et autres

PURPOSE: This study aimed to evaluate the effectiveness of microscope-assisted modified lateral lumbar interbody fusion (micro-XOLIF) and to compare its impact on lumbar sagittal plane imaging parameters with extreme lateral interbody fusion (XLIF). METHODS: We retrospectively collected the data of patients who …

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Oral Eupolyphaga sinensis extract promotes lumbar interbody fusion by enhancing vascularization of cartilage endplate

Ruixin Zhen, Jiaqi Li, Shaorong Li, Han Wu et autres

Objective: (ES) extract on intervertebral fusion in a rabbit model. Methods: A rabbit lumbar lateral interbody fusion model was established. Different treatments were administered to each group, including the control group (CON), oral ES extract group (ES), interbody fusion group (IBF) and …

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Adipocyte RNA-binding protein CELF1 promotes beiging of white fat through stabilizing Dio2 mRNA

Ting Zeng, Liuling Xiao, Jiajie Li, Han Wu et autres

RNA-binding proteins (RBPs) regulate diverse post-transcriptional processes and play roles in adipocyte development; however, their role in white fat beiging remains unclear. Here we identify CUG-BP Elav-like family member 1 (CELF1) as a key RBP promoting beiging of inguinal white adipose tissue …

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A differential diagnostic model based on immunological evaluation and routine laboratory tests: distinguishing multiple myeloma from other disorders with aberrant immunoglobulin elevation

Manning Li, Sixun Jia, Han Wu, Chunyi Shou et autres

OBJECTIVE: Develop a diagnostic model using common hematological and immunological indicators to assist in the early screening and differential diagnosis of Multiple Myeloma (MM) in clinical settings, reducing the risk of misdiagnosis. METHODS: A retrospective analysis was conducted on 274 newly diagnosed …

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