David Matuskey

Exploratory imaging in SWEDD: Insights from dopaminergic PET, synaptic density PET, and volumetric MRI

Faranak Ebrahimian Sadabad, Tommaso Volpi, Sule Tinaz, Praveen Honhar et autres

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Associations between dopaminergic and serotonergic systems in individuals with cocaine use disorder: An exploratory analysis of [¹¹C]PHNO and [¹¹C]P943 PET imaging

Salih Çayır, Binah baht Ysrayl, Esteban Sotomayor Carreño, Alfredo J. Hurtado et autres

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Integrated Investigation of Sex Differences in the Human Nociceptin/Orphanin FQ Receptor System: Postmortem Analyses and In Vivo [11C]NOP-1A Positron Emission Tomography Imaging

Maëva Dhaynaut, Neda R. Morakabati, Kiely Morris, David Matuskey et autres

ABSTRACT Background The nociceptin/orphanin FQ (NOP) system modulates pain, stress, and reward, with emerging evidence for sex-dependent biology. Despite NOP’s hypothesized role in psychopathologies with pronounced sex differences, little is known about sex-associated distribution of NOP receptors. Methods To fill this gap, …

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Widespread synaptic density loss in schizophrenia follows molecular and network architecture

Alex Fornito, Patrick D. Worhunsky, Mika Naganawa, Xi-Han Zhang et autres

Abstract Converging neuroimaging, genetic, and post-mortem evidence highlights the fundamental role of synaptic density reductions in schizophrenia pathogenesis. However, the brain-wide spatial pattern of these alterations and the mechanisms underlying this patterning remain to be established. Here, using [ 11 C]UCB-J radiotracer …

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Effects of Age and BMI on Histamine H3 Receptor Availability in Healthy Humans (P3-12.005)

Yanghong Yang, Waleed Ibrahim, Paul Gravel, brian pittman et autres

To assess alterations in H3R availability with age and body mass index (BMI) in healthy humans using in vivo[11C]GSK189254 positron emission tomography (PET) imaging.

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Optimized reference region and the effect on test-retest reliability and sensitivity to differences between Parkinson’s disease and control groups with [ 11 C]UCB-J

Nikkita Khattar, David Matuskey, Jean-Dominique Gallezot, Mika Naganawa et autres

[ 11 C]UCB-J is a radioligand targeting synaptic vesicle glycoprotein 2A, used to image synaptic density. For quantification, a small-volume centrum semiovale area was previously optimized as a [ 11 C]UCB-J reference region (CS2mL); however, due to its small volume, its high …

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Dose Reduction in Dynamic PET Imaging Using Self-Supervised Two-Step Deep Image Prior

Andi Li, M. H. Syed, Mika Naganawa, David Matuskey et autres

Reducing the radiotracer dose in dynamic brain PET imaging lowers patient radiation exposure but also degrades the signal-to-noise (SNR) ratio and introduces bias in both dynamic frames and resulting parametric images. These effects compromise the accuracy of quantitative assessments of target proteins. …

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Imaging Metabotropic Glutamate Receptor 5 and Excitatory Neural Activity in Autism

Adam Naples, Yanghong Yang, Paul Gravel, Takuya Toyonaga et autres

OBJECTIVE: Autism spectrum disorder is a prevalent and heterogeneous condition with features ranging from social and communication differences to sensory sensitivities. Differences in excitatory neurotransmission have been identified in autism, but the molecular underpinnings are poorly understood. To investigate the mechanism underlying …

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Exceptional brain PET images from the NeuroEXPLORER: scans with targeted radiopharmaceuticals and comparison to HRRT

Tommaso Volpi, Takuya Toyonaga, Nikkita Khattar, Jean‐Dominique Gallezot et autres

Current brain-dedicated positron emission tomography (PET) systems (e.g., the High-Resolution Research Tomograph, HRRT) are unable to accurately and precisely measure pharmacologically-specific signals in small brain regions due to insufficient image resolution and sensitivity. The NeuroEXPLORER (NX), a new ultra-high-performance brain-dedicated scanner, promises …

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Optimized reference region and the effect on test-retest reliability and detection of Parkinson’s disease with [ 11 C]UCB-J

Nikkita Khattar, David Matuskey, Jean‐Dominique Gallezot, Mika Naganawa et autres

Abstract [ 11 C]UCB-J is a radioligand targeting synaptic vesicle glycoprotein 2A, used to image synaptic density. For quantification, a small-volume centrum semiovale area was previously optimized as a [ 11 C]UCB-J reference region (CS2mL); however, its high variability resulted in reduced …

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Measuring Dopamine Transporter Availability and Synaptic Density in Parkinson's Disease: A Dual‐Tracer Positron Emission Tomography Imaging Study

Faranak Ebrahimian Sadabad, Tommaso Volpi, Praveen Honhar, Sule Tinaz et autres

Abstract Background 18 F‐FE‐PE2I is a highly selective dopamine transporter (DAT) positron emission tomography (PET) radioligand, whereas 11 C‐UCB‐J targets synaptic vesicle glycoprotein 2A (SV2A), enabling the assessment of synaptic density. Both tracers show significant alterations in Parkinson's disease (PD) in nigrostriatal …

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Carotid Artery Image-Derived Blood TimeActivity Curves on the NeuroEXPLORER: Initial Multitracer Validation Against Arterial Sampling

Tommaso Volpi, Jean-Dominique Gallezot, Shannan Henry, Mark Dias et autres

Image-derived input functions are noninvasive alternatives to arterial blood sampling for PET kinetic modeling, allowing one to measure the whole-blood time–activity curve (BTAC). However, partial-volume effects have limited the use of carotid arteries (CA) to generate image-derived BTACs (ID-BTAC) for brain PET. …

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