Suat Şimşek

Nε-(carboxymethyl)lysine-modified albumin exacerbates doxorubicin-induced NOX5-dependent oxidative stress in endothelial cells

Zhu Jiang, Ingeborg S. E. Waas, Suat Şimşek, Casper G. Schalkwijk et autres

INTRODUCTION: -(carboxymethyl)lysine (CML) and activation of its receptor, RAGE (receptor for advanced glycation end-products) in the cardiac microvasculature, potentially driven by NADPH oxidase (NOX)-mediated oxidative stress. NOX5 is a critical contributor to endothelial dysfunction. But its role, alongside extracellular CML, in Dox-induced …

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StemBell Therapy Does Not Significantly Affect Atherosclerotic Plaque Characteristics in a Streptozotocin-Induced Diabetes Mellitus Mouse Model

Amber Korn, Suat Şimşek, Mitchell D. Fiet, Ingeborg S. E. Waas et autres

Aims: Diabetes mellitus (DM) increases cardiovascular risk by inducing atherosclerotic plaque instability. StemBell therapy (i.e., adipose tissue-derived stem cells (ASCs) coupled to ultrasound-activated microbubbles) previously improved plaque stability in non-DM ApoE−/− mice. Here, we investigated the effect of StemBell therapy on atherosclerotic …

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BURHAN FELEK VE REFİ' CEVAD ULUNAY'IN TÜRK MÜZİĞİ HAKKINDAKİ GÖRÜŞLERİNİN KARŞILAŞTIRILMASI

Suat Şimşek

Türkiye’de müzik sosyolojisi alanındaki çalışmaların temel konularından birisi Türk müziği tartışmalarıdır. Bu konu Cumhuriyet devri basınında da sıklıkla işlenmiş ve dönemin yazarları Türk müziğine dair bu tartışmalara müdahil olmuşlardır. Bu yazarlar arasında Burhan Felek (1889-1982) ve Refi’ Cevad Ulunay’ın (1890-1968) önemli bir …

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Eminönü Yeni Cami Hünkâr Kasrı’nın Yıkılmasının 1930’lu Yıllarda Gündeme Gelmesi ve Türk Basınındaki Tartışmalar

Suat Şimşek

İstanbul’un Eminönü semtinde 1597-1663 yılları arasında inşa edilen Yeni Cami, tarihi değerinin yanı sıra, Eminönü meydanında bulunması sebebiyle şehrin en görünür yapılarından biridir. Camiye bitişik olarak inşa edilen Hünkâr Kasrı ise 17. yüzyıl Türk sivil mimarisini yansıtmaktadır ve kasrın iç mekânı, çinicilik, …

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Increased perivascular fibrosis and pro-fibrotic cellular transition in intramyocardial blood vessels in myocardial infarction patients

Suat Şimşek, Joris J. T. H. Roelofs, Hans W.M. Niessen, Paul A.J. Krijnen

Background and objectives: Structural and functional changes in the intramyocardial microcirculation increase the risk of myocardial infarction (MI). This study investigated intramyocardial perivascular fibrosis and pro-fibrotic cellular transitions in deceased acute and subacute MI patients to explore their involvement in the pathogenesis …

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Combined evaluation of liver and kidney function improves prediction of clinical outcome in patients with chronic heart failure and reduced ejection fraction

Dominika Klimczak‐Tomaniak, Miloš Branković, Nick van Boven, K. Martijn Akkerhuis et autres

Abstract Background/Introduction The liver and the kidneys are important organs for body homeostasis and are both affected by heart failure (HF) either by systemic venous congestion or hypoperfusion. Purpose We aimed to verify whether the Model for End-stage Liver Disease eXcluding International …

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The association of inflammatory markers with frailty and in-hospital mortality in older COVID-19 patients

Estelle Tran Van Hoi, Brent Appelman, Simon P. Mooijaart, Virgil A. S. H. Dalm et autres

INTRODUCTION: During the COVID19 pandemic, older patients hospitalized for COVID-19 exhibited an increased mortality risk compared to younger patients. While ageing is associated with compromised immune responses and frailty, their contributions and interplay remain understudied. This study investigated the association between inflammatory …

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Application of adipose tissue-derived stem cell therapy with a clinically relevant dose does not significantly affect atherosclerotic plaque characteristics in a streptozotocin-induced hyperglycaemia mouse model

Amber Korn, Suat Şimşek, Mitchell D. Fiet, Ingeborg S. E. Waas et autres

Diabetes mellitus (DM) induces increased inflammation of atherosclerotic plaques, resulting in elevated plaque instability. Mesenchymal stem cell (MSC) therapy was shown to decrease plaque size and increase stability in non-DM animal models. We now studied the effect of MSC therapy in a …

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Lanreotide versus placebo for tumour reduction in patients with a 68Ga-DOTATATE PET-positive, clinically non-functioning pituitary macroadenoma (GALANT study): a randomised, multicentre, phase 3 trial with blinded outcome assessment

Tessel M. Boertien, Madeleine L. Drent, Jan Booij, Charles B.L.M. Majoie et autres

Background No established medical treatment options currently exist for patients with non-functioning pituitary macroadenoma (NFPMA). Somatostatin analogues may prevent tumour growth, but randomised controlled trials are lacking. In vivo somatostatin receptor assessment with 68 Ga-DOTATATE PET could help in selecting patients for …

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Lanreotide in patients with a 68Ga-DOTATATE PET-positive, clinically non-functioning pituitary macroadenoma (GALANT study): A randomised, double-blind, placebo-controlled trial

Tessel M. Boertien, Marjolein Drent, Jan Booij, Charles B.L.M. Majoie et autres

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Increased perivascular fibrosis and pro-fibrotic cellular transition in intramyocardial blood vessels in patients with myocardial infarction

G Sorrentino, Suat Şimşek, Hans W.M. Niessen, Paul A.J. Krijnen

Abstract Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): China Scholarship Council Background Myocardial infarction (MI) is pathologically characterized by irreversible myocardial necrosis caused by ischemia. Intramyocardial vascular dysfunction is believed to increase the risk …

Temporal evolution of liver function parameters predicts clinical outcome in chronic heart failure patients (Bio-SHiFT study)

Dominika Klimczak‐Tomaniak, Karolina Andrzejczyk, Sabrina Abou Kamar, Sara J. Baart et autres

BACKGROUND: Liver dysfunction contributes to worse clinical outcomes in heart failure (HF) patients. However, studies exploring temporal evolutions of liver function parameters in chronic HF (CHF) pa- tients, and their associations with clinical outcome, are scarce. Detailed temporal patterns of alkaline phosphatase …

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