Sherea Long

Prior vaccination promotes early activation of memory T cells and enhances immune responses during SARS-CoV-2 breakthrough infection

Mark M. Painter, Timothy S. Johnston, Kendall A. Lundgreen, Jefferson José da Silva Santos et autres

us, jp (code pays fourni par la source)

Prior vaccination enhances immune responses during SARS-CoV-2 breakthrough infection with early activation of memory T cells followed by production of potent neutralizing antibodies

Mark M. Painter, Timothy S. Johnston, Kendall A. Lundgreen, Jefferson José da Silva Santos et autres

SARS-CoV-2 infection of vaccinated individuals is increasingly common but rarely results in severe disease, likely due to the enhanced potency and accelerated kinetics of memory immune responses. However, there have been few opportunities to rigorously study early recall responses during human viral …

us (code pays fourni par la source)

Efficient recall of Omicron-reactive B cell memory after a third dose of SARS-CoV-2 mRNA vaccine

Rishi R. Goel, Mark M. Painter, Kendall A. Lundgreen, Sokratis A. Apostolidis et autres

us, au (code pays fourni par la source)

Efficient recall of Omicron-reactive B cell memory after a third dose of SARS-CoV-2 mRNA vaccine

Rishi R. Goel, Mark M. Painter, Kendall A. Lundgreen, Sokratis A. Apostolidis et autres

Abstract Despite a clear role in protective immunity, the durability and quality of antibody and memory B cell responses induced by mRNA vaccination, particularly by a 3 rd dose of vaccine, remains unclear. Here, we examined antibody and memory B cell responses …

us, au (code pays fourni par la source)

mRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern

Rishi R. Goel, Mark M. Painter, Sokratis A. Apostolidis, Divij Mathew et autres

Immune memory after vaccination Vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has proven highly effective at preventing severe COVID-19. However, the evolution of viral variants, and waning antibody levels over time, raise questions regarding the longevity of vaccine-induced immune protection. …

us, au (code pays fourni par la source)

mRNA Vaccination Induces Durable Immune Memory to SARS-CoV-2 with Continued Evolution to Variants of Concern

Rishi R. Goel, Mark M. Painter, Sokratis A. Apostolidis, Divij Mathew et autres

SARS-CoV-2 mRNA vaccines have shown remarkable efficacy, especially in preventing severe illness and hospitalization. However, the emergence of several variants of concern and reports of declining antibody levels have raised uncertainty about the durability of immune memory following vaccination. In this study, …

us, au (code pays fourni par la source)

Rapid induction of antigen-specific CD4+ T cells is associated with coordinated humoral and cellular immunity to SARS-CoV-2 mRNA vaccination

Mark M. Painter, Divij Mathew, Rishi R. Goel, Sokratis A. Apostolidis et autres

us (code pays fourni par la source)

Rapid induction of antigen-specific CD4 + T cells guides coordinated humoral and cellular immune responses to SARS-CoV-2 mRNA vaccination

Mark M. Painter, Divij Mathew, Rishi R. Goel, Sokratis A. Apostolidis et autres

Summary The SARS-CoV-2 mRNA vaccines have shown remarkable clinical efficacy, but questions remain about the nature and kinetics of T cell priming. We performed longitudinal antigen-specific T cell analyses in healthy individuals following mRNA vaccination. Vaccination induced rapid near-maximal antigen-specific CD4 + …

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Distinct antibody and memory B cell responses in SARS-CoV-2 naïve and recovered individuals after mRNA vaccination

Rishi R. Goel, Sokratis A. Apostolidis, Mark M. Painter, Divij Mathew et autres

Novel mRNA vaccines for SARS-CoV-2 have been authorized for emergency use. Despite their efficacy in clinical trials, data on mRNA vaccine-induced immune responses are mostly limited to serological analyses. Here, we interrogated antibody and antigen-specific memory B cells over time in 33 …

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Longitudinal Analysis Reveals Distinct Antibody and Memory B Cell Responses in SARS-CoV2 Naïve and Recovered Individuals Following mRNA Vaccination

Rishi R. Goel, Sokratis A. Apostolidis, Mark M. Painter, Divij Mathew et autres

Novel mRNA vaccines for SARS-CoV2 have been authorized for emergency use and are currently being administered to millions of individuals worldwide. Despite their efficacy in clinical trials, there is limited data on vaccine-induced immune responses in individuals with a prior SARS-CoV2 infection …

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The COVID-19 immune landscape is dynamically and reversibly correlated with disease severity

Hamid Bolouri, Cate Speake, David A. G. Skibinski, Sherea Long et autres

Abstract Despite a rapidly growing body of literature on COVID-19, our understanding of the immune correlates of disease severity, course and outcome remains poor. Using mass cytometry, we assessed the immune landscape in longitudinal whole blood specimens from 59 patients presenting with …

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Bovine Insulin and Porcine or Human Insulin Prime Distinct CD4+ T Cell Subsets in C57BL/6 Mice

Sherea Long, Michał Zimecki, Judith A. Kapp

us, pl (code pays fourni par la source)