Travis L. Unger

Secreted GPNMB enhances uptake of fibrillar alpha-synuclein in a non-cell-autonomous process that can be blocked by anti-GPNMB antibodies

Marc Carceles‐Cordon, Eliza M. Brody, Masen L. Boucher, Michael D. Gallagher et autres

Glycoprotein nonmetastatic melanoma B (GPNMB) is critical to cellular uptake of pathological forms of alpha-synuclein (aSyn), the hallmark disease protein in Parkinson's disease (PD). Here, we demonstrate that the non-membrane-anchored, extracellular domain of GPNMB can function in a non-cell-autonomous manner. In the …

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Secreted GPNMB enhances uptake of fibrillar alpha-synuclein in a non-cell-autonomous process that can be blocked by anti-GPNMB antibodies

Marc Carceles‐Cordon, Eliza M. Brody, Masen L. Boucher, Michael D. Gallagher et autres

ABSTRACT Glycoprotein nonmetastatic melanoma B (GPNMB), encoded by the target gene ( GPNMB ) of a Parkinson’s disease (PD) risk locus, acts as a secreted factor mediating inflammatory effects in the context of immunity and cancer. In a neurodegenerative disease context, GPNMB …

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The Source and Pathogenic Potential of Blood-derived Alpha-Synuclein (S4.010)

George T. Kannarkat, R. Tyler Skrinak, Travis L. Unger, Rebecca Zack et autres

This study investigates the source and pathogenic potential of blood-based alpha-synuclein (aSyn) using conformation-selective antibodies.

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Testing for Allele-specific Expression from Human Brain Samples

Maria E. Diaz‐Ortiz, Nimansha Jain, Michael D. Gallagher, Marijan Posavi et autres

allele-specific expression (ASE) in brain lysates from cognitively normal controls (NC) and Parkinson's disease (PD) individuals. • Builds on the ASE protocol of Mayba et al. (2014) and extends application from cells to human tissue. • Increased sensitivity by enrichment for desired …

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GPNMB confers risk for Parkinson’s disease through interaction with α-synuclein

Maria E. Diaz‐Ortiz, Yunji Seo, Marijan Posavi, Marc Carceles Cordon et autres

Many risk loci for Parkinson’s disease (PD) have been identified by genome-wide association studies (GWASs), but target genes and mechanisms remain largely unknown. We linked the GWAS-derived chromosome 7 locus (sentinel single-nucleotide polymorphism rs199347) to GPNMB through colocalization analyses of expression quantitative …

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Plasma MIA , CRP , and Albumin Predict Cognitive Decline in Parkinson's Disease

Junchao Shen, Noor Amari, Rebecca Zack, R. Tyler Skrinak et autres

OBJECTIVE: Using a multi-cohort, discovery-replication-validation design, we sought new plasma biomarkers that predict which individuals with Parkinson's disease (PD) will experience cognitive decline. METHODS: In 108 discovery cohort PD individuals and 83 replication cohort PD individuals, we measured 940 plasma proteins on …

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Plasma MIA, CRP, and albumin predict cognitive decline in Parkinson’s Disease

Junchao Shen, Noor Amari, Rebecca Zack, R. Tyler Skrinak et autres

ABSTRACT Objective Using a multi-cohort, Discovery-Replication-Validation design, we sought new plasma biomarkers that predict which PD individuals will experience cognitive decline. Methods In 108 Discovery Cohort PD individuals and 83 Replication Cohort PD individuals, we measured 940 plasma proteins on an aptamer-based …

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TMEM106B modifies TDP-43 pathology in human ALS brain and cell-based models of TDP-43 proteinopathy

Fei Mao, John Robinson, Travis L. Unger, Marijan Posavi et autres

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TMEM106B modifies TDP-43 pathology in human ALS brain and cell-based models of TDP-43 proteinopathy

Fei Mao, John Robinson, Travis L. Unger, Marijan Posavi et autres

ABSTRACT The neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with TAR DNA-binding protein-43 (TDP-43) inclusions (FTLD-TDP) share the neuropathological hallmark of aggregates of TDP-43. However, factors governing the severity and regional distribution of TDP-43 pathology, which may account for …

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Interaction of the Frontotemporal Dementia-Associated Protein TMEM106B With VAMP8 in Lysosome-Autophagosome Fusion

Elisia Clark, Rakshita A. Charan, Travis L. Unger, Johanna Busch et autres

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Author Correction: Aberrant activation of non-coding RNA targets of transcriptional elongation complexes contributes to TDP-43 toxicity

Chia-Yu Chung, Amit Berson, Jason R. Kennerdell, Ashley Sartoris et autres

The original version of this Article contained an error in the author affiliations. The affiliation of Alice Chen-Plotkin with the Department of Neurology, Perelman School of Medicine, Philadelphia, PA, 19104 USA was inadvertently omitted. This has now been corrected in both the …

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Aberrant activation of non-coding RNA targets of transcriptional elongation complexes contributes to TDP-43 toxicity

Chia‐Yu Chung, Amit Berson, Jason R. Kennerdell, Ashley Sartoris et autres

TDP-43 is the major disease protein associated with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with ubiquitinated inclusions (FTLD-TDP). Here we identify the transcriptional elongation factor Ell-a shared component of little elongation complex (LEC) and super elongation complex (SEC)-as a strong …

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