Dimitrios Georgopoulos

Reply to Domínguez de la Cruz et al.: Little Big Issues in Brain-Lung Crosstalk.

Dimitrios Georgopoulos

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Reply to Domínguez de la Cruz et al. : Little Big Issues in Brain–Lung Crosstalk

Dimitrios Georgopoulos

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Mechanical Ventilation in Patients with Acute Brain Injuries: A Pathophysiology-based Approach

Dimitrios Georgopoulos, Shaurya Taran, Maria Bolaki, Evangelia Akoumianaki

Applying mechanical ventilation and selecting ventilatory strategies in patients with acute brain injuries, especially those with lung damage, is challenging. Static (positive end-expiratory pressure) and dynamic (intratidal) changes in ventilator pressure, via complex pathways, influence cerebral arterial inflow and cerebral venous pressure …

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Dexmedetomidine as sedative agent for flexible bronchoscopy: efficacy and patient satisfaction

Vaia Stamatopoulou, Irini Lambiri, Konstantinos Karagiannis, Eirini Vasarmidi et autres

Introduction: Dexmedetomidine, an a2-adrenoceptor agonist is considered a safe sedative option for procedural conscious sedation, including bronchoscopy. Aims and objectives: This study sought to investigate the efficacy of dexmedetomidine as a sedative agent during bronchoscopy focusing primarily on monitoring vital signs, bronchoscopy …

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Ubiquity of models describing inspiratory effort dynamics in patients on pressure support ventilation

Jennifer L. Knopp, Yeong Shiong Chiew, Dimitrios Georgopoulos, Geoffrey M. Shaw et autres

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Driving pressure of respiratory system and lung stress in mechanically ventilated patients with active breathing

Vaia Stamatopoulou, Evangelia Akoumianaki, Katerina Vaporidi, Efstathios Stamatopoulos et autres

Abstract Background During control mechanical ventilation (CMV), the driving pressure of the respiratory system (ΔP rs) serves as a surrogate of transpulmonary driving pressure (ΔP lung). Expiratory muscle activity that decreases end-expiratory lung volume may impair the validity of ΔP rs to …

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Hiccup-like Contractions in Mechanically Ventilated Patients: Individualized Treatment Guided by Transpulmonary Pressure

Evangelia Akoumianaki, Maria Bolaki, Georgios Prinianakis, Ioannis Konstantinou et autres

Hiccups-like contractions, including hiccups, respiratory myoclonus, and diaphragmatic tremor, refer to involuntary, spasmodic, and inspiratory muscle contractions. They have been repeatedly described in mechanically ventilated patients, especially those with central nervous damage. Nevertheless, their effects on patient-ventilator interaction are largely unknown, and …

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Dyspnea in the ICU: It Is Difficult to See What Patients Feel

Robert B. Banzett, Dimitrios Georgopoulos

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Neural Network-Enabled Identification of Weak Inspiratory Efforts during Pressure Support Ventilation Using Ventilator Waveforms

Stella Soundoulounaki, Emmanouil Sylligardos, Evangelia Akoumianaki, Μάρκος Σιγάλας et autres

During pressure support ventilation (PSV), excessive assist results in weak inspiratory efforts and promotes diaphragm atrophy and delayed weaning. The aim of this study was to develop a classifier using a neural network to identify weak inspiratory efforts during PSV, based on …

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Impact of Molecular Syndromic Diagnosis of Severe Pneumonia in the Management of Critically Ill Patients

Dimitra Stafylaki, Sofia Maraki, Katerina Vaporidi, Dimitrios Georgopoulos et autres

The impact of syndromic molecular diagnosis in the management of nosocomial infections caused by MDR/XDR pathogens has been incompletely characterized. We evaluated the performance of a molecular syndromic platform (BioFire FilmArray -Pneumonia plus Panel) in 79 patients with pneumonia in the intensive …

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Oxidant/Antioxidant Status Is Impaired in Sepsis and Is Related to Anti-Apoptotic, Inflammatory, and Innate Immunity Alterations

Marianna Miliaraki, Panagiotis Briassoulis, Stavroula Ilia, Kalliopi Michalakakou et autres

Oxidative stress is considered pivotal in the pathophysiology of sepsis. Oxidants modulate heat shock proteins (Hsp), interleukins (IL), and cell death pathways, including apoptosis. This multicenter prospective observational study was designed to ascertain whether an oxidant/antioxidant imbalance is an independent sepsis discriminator …

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COVID-19 ARDS: Points to Be Considered in Mechanical Ventilation and Weaning

Εumorfia Kondili, Demosthènes Makris, Dimitrios Georgopoulos, Νikoletta Ρovina et autres

The COVID-19 disease can cause hypoxemic respiratory failure due to ARDS, requiring invasive mechanical ventilation. Although early studies reported that COVID-19-associated ARDS has distinctive features from ARDS of other causes, recent observational studies have demonstrated that ARDS related to COVID-19 shares common …

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