Jorge Henao‐Mejia

Functional chimeric mRNAs encode proteins in mammalian immunity

Olivia Venezia, Harry Kane, Gang Du, Hannah D. Coughlan et autres

Abstract Individual mammalian mRNAs and proteins are typically believed to originate from single genomic loci, with isoform diversity arising through cis -splicing of pre-mRNA. Whether mRNA from distant genes can undergo trans -splicing to generate functionally relevant chimeric transcripts has remained unclear. …

us, cn, au (code pays fourni par la source)

Scaffolding-dependent CASP1 constrains excessive cell-intrinsic inflammatory signaling in leukemia

Emma E. Uible, Issac Choi, Courtnee A. Clough, Aishlin Hassan et autres

Caspase-1 (CASP1) is best known for regulating IL-1β processing and pyroptosis; however, its role in leukemia has not been clearly defined. Here, we show that loss of CASP1 impairs leukemic cell growth, drives differentiation, and reduces leukemic burden in vivo, independent of …

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Dietary saturated fatty acids promote lung myeloid cell inflammasome activation and IL-1β–mediated inflammation in mice and humans

Sam J. McCright, Olivia Harding, Julia Chini, Nicole DeMarco et autres

Resident tissue macrophages and monocytes (RTMs) integrate local and systemic signals to coordinate immune cell function at homeostasis and in response to inflammatory stimuli. Obesity-associated metabolic dysfunction drives the development of RTM populations that contribute to disease states in multiple tissues. However, …

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Mitochondrial complex IV remodeling in tumor-associated macrophages amplifies interferon signaling and promotes anti-tumor immunity

Megan L. Clark, Kamen P. Simeonov, Walter K. Mowel, Michaël F. Michieletto et autres

us, Afrique du Sud (code pays fourni par la source)

Skin damage signals mediate allergic sensitization to spatially unlinked antigen

Daniel A. Waizman, Isabela Brown‐Soler, Anjelica L. Martin, Yifan Ma et autres

Our current understanding of immunity to pathogens suggests that anatomic coupling of antigens with danger signals is a required feature for the formation of immune memory. However, in the context of pathogen-independent inflammation, the stringency of this anatomical coupling is unclear. Here, …

us, fr (code pays fourni par la source)

Myeloid-derived miR-6236 potentiates adipocyte insulin signaling and prevents hyperglycemia during obesity

Bam Paneru, Julia Chini, Sam J. McCright, Nicole DeMarco et autres

Adipose tissue macrophages (ATMs) influence obesity-associated metabolic dysfunction, but the mechanisms by which they do so are not well understood. We show that miR-6236 is a bona fide miRNA that is secreted by ATMs during obesity. Global or myeloid cell-specific deletion of …

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TIF1γ regulates stability of T regulatory cells during inflammation

Eugenio Contreras-Castillo, Jesús Daniel Zambrano-Romero, Diego Pérez-Vázquez, María Guadalupe García-Patiño et autres

Abstract T regulatory cells are a suppressor population critical to control inflammation and maintain tissue homeostasis. The TGF-β pathway is a fundamental signal for T regulatory cell differentiation, yet the molecular determinants of how TGF-β signals regulate all these processes are not …

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Deleting the mitochondrial respiration negative regulator MCJ enhances the efficacy of CD8+ T cell adoptive therapies in pre-clinical studies

Meng‐Han Wu, Felipe Valença-Pereira, Francesca Isabelle Cendali, Emily L. Giddings et autres

Abstract Mitochondrial respiration is essential for the survival and function of T cells used in adoptive cellular therapies. However, strategies that specifically enhance mitochondrial respiration to promote T cell function remain limited. Here, we investigate methylation-controlled J protein (MCJ), an endogenous negative …

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The impact of pediatric obesity on T cell function

Ceire A. Hay, Samir Sayed, Montana Knight, Jose S. Campos et autres

Abstract The increasing prevalence of childhood obesity is an urgent public health crisis. Children with obesity (≥ 95th percentile BMI for age and sex) are at an increased risk for developing asthma as well as cardiometabolic and autoimmune disorders. However, the mechanisms …

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Abstract 4013: Increasing mitochondrial respiration by silencing MCJ/DnaJC15 enhances CD8 CAR-T cell therapy efficacy

Meng‐Han Wu, Emily L. Giddings, Felipe Valença-Pereira, Catherine Pham‐Danis et autres

Abstract Chimeric antigen receptor (CAR)-T cell therapy is a promising treatment against leukemia and lymphoma. However, poor initial treatment response and post-therapy relapse have found to be common and remained to be resolved. Modulating T cell immunometabolism is considered a novel therapeutic …

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Nmes1 is a novel regulator of mucosal response influencing intestinal healing potential

Madeleine Hamley, Stephanie Leyk, Christian Casar, Imke Liebold et autres

Abstract The initiation of tissue remodeling following damage is a critical step in preventing the development of immune‐mediated diseases. Several factors contribute to mucosal healing, leading to innovative therapeutic approaches for managing intestinal disorders. However, uncovering alternative targets and gaining mechanistic insights …

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Author response for "Nmes1 is a novel regulator of mucosal response influencing intestinal healing potential"

Madeleine Hamley, Stephanie Leyk, Christian Casar, Imke Liebold et autres