Arum Han

Biosynthesis of cyanophycin by high-cell-density cultivation of recombinant Escherichia coli for corrosion-resistant biomaterial applications

Saroj Raj Kafle, Anirudh Mukunth, Arum Han, Arul Jayaraman et autres

Cyanophycin granule polypeptide (CGP), also known as multi-L-arginyl-poly(aspartic acid), is a biodegradable biopolymer composed primarily of aspartic acid and arginine. Due to its versatile functional properties, CGP has attracted increasing interest for potential applications in food, medicine, cosmetics, agriculture, and corrosion inhibition. …

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DURABLE: A Workflow for Determining Corrosion-Driving and Protective Microbial Mechanisms

Aifen Zhou, Yuwen Li, Han Zhang, Evelyn Callaway et autres

Microbiologically influenced corrosion (MIC) threatens global infrastructure, causing billions of dollars in annual losses. Its persistence stems from unresolved mechanisms─particularly the metabolites produced by microorganisms that drive or inhibit corrosion─and the microbial community structures. Progress has been hindered by the absence of …

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Polychip‐A High‐Throughput Droplet Microfluidics Platform for Interrogating Microbial Interactions

Jeong Jae Han, Adrian Ryan Guzman, Aifen Zhou, Han Zhang et autres

ABSTRACT Microbial interactions are fundamental to ecology, health, and disease, yet high‐throughput tools to study these complex relationships remain scarce. We introduce Polychip, a fully integrated, high‐throughput droplet microfluidics platform that revolutionizes microbial interaction screening. By seamlessly combining six microfluidic operations onto …

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A Synthetic Microbial Therapy Rewires Antitumor Immunity Across Multiple Cancer Types

Jugal Kishore Das, Qing‐Ming Qin, Shailbala Singh, Christina James Thomas et autres

Microbial immunotherapies show promise against cancer, yet broad efficacy and mechanistic insight remain elusive. Here, we introduce SPIKE 1.0 (S1.0), a metabolically engineered bacterium that converts tryptophan into immunomodulatory hydroxyindoles via tryptophan monooxygenase to remodel the tumor microenvironment (TME). A single systemic …

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Integrated bioprocess development for cyanophycin production as a corrosion-inhibiting biomaterial

Saroj Raj Kafle, Anirudh Mukunth, Arum Han, Arul Jayaraman et autres

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Fetal response to maternal exposures of environmental chemicals: Utility of a four-cell human feto-maternal interface organ-on-chip

Haley L. Moyer, Sung‐Jin Kim, Lauren Richardson, Han-Hsuan Doris Tsai et autres

Epidemiological studies suggest that maternal exposures to environmental pollutants may be linked to spontaneous preterm birth. Mechanistic studies are needed to provide support to these hypotheses; however, existing in vitro models do not replicate human feto-maternal barriers beyond placenta. The recently developed …

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Acousto-viscoelastic droplet microfluidics enhancing single particle-in-droplet encapsulation unlimited by the Poisson distribution

Youngseo Cho, Songi Han, Arum Han, Ok Chan Jeong et autres

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P2.02.16 Identification of Deruxtecan-Induced Methylome Signature in NSCLC Cell Lines

Adam C. Gower, Shengchun Li, Naeimeh Kamranpour, Tristan Grogan et autres

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PRISM: A platform for illuminating viral dark matter

Han Zhang, Justin X. Boeckman, Rohit K. Gupte, Ashlee Prejean et autres

Abstract The exploration of bacteriophage diversity remains constrained by reliance on conventional plaque assays, which bias discovery toward phages that form visible plaques and propagate efficiently. The discovery process, as well as measuring correct phage concentrations and phage resistance frequencies, are also …

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Bacterial Therapeutics: Addressing the Affordability Gap in Cancer Therapy

Chiswili Yves Chabu, Koichi S. Kobayashi, Jianxun Jim Song, Arum Han et autres

The global cancer care burden is projected to reach $25 trillion by 2050, with the United States experiencing increasing costs from $57 billion to $209 billion. The application of expensive cellular immunotherapies (exceeding $300,000 per treatment) will exacerbate escalating cancer care costs. …

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Draft genome of a polyurethane-utilizing bacterium Pseudomonas sp. PHC1

Jooho Chung, Arum Han, Kung‐Hui Chu

ABSTRACT We report a draft genome sequence of Pseudomonas sp. PHC1, capable of utilizing polyurethane (PUR) as sole carbon and sole nitrogen sources.

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Exosomal Delivery of Interleukin‐10 Reduces Infection‐Associated Inflammation in a 3D ‐Printed Model of a Humanized Feto–Maternal Interface

Leah Saylor, Rahul Cherukuri, Ananth Kumar Kammala, Lauren Richardson et autres

Spontaneous preterm birth (PTB) is associated with fetal inflammatory responses that are due to infections. Effective interventions to minimize these fetal responses are limited as drugs do not usually cross the feto-maternal interface (FMi) barrier, and reliable models to test drug efficacy …

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