F Ponz

A Multifunctionalized Potyvirus-Derived Nanoparticle That Targets and Internalizes into Cancer Cells

Daniel A. Truchado, María Juárez‐Molina, Sara Rincón, Lucía Zurita et autres

Plant viral nanoparticles (VNPs) are attractive to nanomedicine researchers because of their safety, ease of production, resistance, and straightforward functionalization. In this paper, we developed and successfully purified a VNP derived from turnip mosaic virus (TuMV), a well-known plant pathogen, that exhibits …

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Antigen-functionalized turnip mosaic virus nanoparticles increase antibody sensing in saliva. A case study with SARS-CoV-2 RBD

Carlos Medrano-Arranz, Sara Rincón, Lucía Zurita, F Ponz et autres

Nanoparticles derived from plant viruses play an important role in nanomedicine due to their biocompatibility, self-assembly and easily-modifiable surface. In this study, we developed a novel platform for increasing antibody sensing using viral nanoparticles derived from turnip mosaic virus (TuMV) functionalized with …

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A Multifunctionalized Potyvirus-Derived Nanoparticle That Targets and Internalizes into Cancer Cells

Daniel A. Truchado, María Juárez‐Molina, Sara Rincón, Lucía Zurita et autres

Plant viral nanoparticles (VNPs) are attractive to researchers in nanomedicine due to their safety, easy production, resistance, and straightforward functionalization. In this paper, we developed and successfully purified a VNP derived from turnip mosaic virus (TuMV), a well-known plant pathogen, that exhibits …

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Intrinsic disorder in the dynamic evolution of structure, stability, and flexibility of potyviral VLP assemblies: A computational study

Luis Fernandez Pacios, Flora Sánchez, F Ponz

An all-atom Molecular Dynamics (MD) study was applied to three viral nanoparticles (VLPs) of Turnip mosaic virus (TuMV), a potyvirus: the particles genetically functionalized with two peptides, VIP (human vasoactive intestinal peptide) and VEGFR (peptide derived from the human receptor 3 of …

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Editorial: Plant science’s contribution to fighting viral pandemics: COVID-19 as a case study, volume II

F Ponz, Linda Avesani

This RESEARCH TOPIC is a continuation of the previous Volume I under the same title. We already considered the increasing role of plants and plant biotechnology in different areas of the fight against diseases, including viral pandemics. A significant step in the …

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Structural intrinsic disorder in a functionalized potyviral coat protein as a main viability determinant of its assembled nanoparticles

Marina Mínguez-Toral, Luis Fernandez Pacios, Flora Sánchez, F Ponz

The viability of viral-derived nanoparticles (virions and VLPs) aimed to nanobiotechnological functionalizations of the coat protein (CP) of turnip mosaic virus has been studied by means of advanced computational methodologies that include molecular dynamics. The study has allowed to model the structure …

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Isopeptide Bonding In Planta Allows Functionalization of Elongated Flexuous Proteinaceous Viral Nanoparticles, including Non-Viable Constructs by Other Means

Daniel A. Truchado, Sara Rincón, Lucía Zurita, Flora Sánchez et autres

Plant viral nanoparticles (VNPs) have become an attractive platform for the development of novel nanotools in the last years because of their safety, inexpensive production, and straightforward functionalization. Turnip mosaic virus (TuMV) is one example of a plant-based VNP used as a …

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Corrigendum: Suitability of potyviral recombinant virus-like particles bearing a complete food allergen for immunotherapy vaccines

Diego Pazos‐Castro, Clémence Margain, Zulema Gonzalez Klein, Marina Amores-Borge et autres

[This corrects the article DOI: 10.3389/fimmu.2022.986823.].

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Turnip Mosaic Virus Nanoparticles: A Versatile Tool in Biotechnology

Daniel A. Truchado, Sara Rincón, Lucía Zurita, F Ponz

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Suitability of potyviral recombinant virus-like particles bearing a complete food allergen for immunotherapy vaccines

Diego Pazos‐Castro, Clémence Margain, Zulema Gonzalez Klein, Marina Amores-Borge et autres

Virus-like particles (VLPs) have been gaining attention as potential platforms for delivery of cargos in nanomedicine. Although animal viruses are largely selected due to their immunostimulatory capacities, VLPs from plant viruses constitute a promising alternative to be considered. VLPs derived from Turnip …

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Gelatin-methacryloyl hydrogels containing turnip mosaic virus for fabrication of nanostructured materials for tissue engineering

Ivonne González‐Gamboa, Edith Velázquez-Lam, Matías José Lobo-Zegers, Ada I. Frías-Sánchez et autres

Current tissue engineering techniques frequently rely on hydrogels to support cell growth, as these materials strongly mimic the extracellular matrix. However, hydrogels often need ad hoc customization to generate specific tissue constructs. One popular strategy for hydrogel functionalization is to add nanoparticles …

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Antitumor Applications of Polyphenol-Conjugated Turnip Mosaic Virus-Derived Nanoparticles

Edith Velázquez-Lam, Jaime Tomé‐Amat, Carmen Segrelles, Carmen Yuste-Calvo et autres

Background: Filamentous plant virus-derived nanoparticles are biodegradable and noninfectious to humans. Their structure is also amenable to chemical modifications. They constitute an appealing material for biomedical applications including imaging and drug delivery. We had previously used turnip mosaic virus-derived nanoparticles (TuMV-NPs) to …

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