Olabisi Oluwabukola Coker

Mo1540: GUT MICROBIAL STRUCTURAL VARIATIONS ARE ASSOCIATED WITH COLORECTAL CANCER PROGRESSION

Luyao Wang, Olabisi Oluwabukola Coker, Yufeng Lin, Kai Yuan et autres

Intraneoplastic fungal dysbiosis is associated with colorectal cancer progression and host gene mutation

Kai Yuan, Hongzhi Xu, Shengmian Li, Olabisi Oluwabukola Coker et autres

BACKGROUND: The relationship between intraneoplastic fungi and colorectal cancer (CRC) progression remains largely unclear. Here, we investigated fungal community changes in adenoma and CRC and their correlation with host genetic mutations. METHODS: We obtained 261 tissue biopsies from two geographically distinct cohorts …

hk, cn (code pays fourni par la source)

Multi-Cohort Analysis Reveals Altered Archaea in Colorectal Cancer Fecal Samples Across Populations

Tianhui Li, Olabisi Oluwabukola Coker, Yang Sun, Shiyu Li et autres

BACKGROUND & AIMS: Archaea are important components of the host microbiome, but their roles in colorectal cancer (CRC) remain largely unclear. We aimed to elucidate the contribution of gut archaea to CRC across multiple populations. METHODS: This study incorporated fecal metagenomic data …

hk, cn (code pays fourni par la source)

Streptococcus anginosus promotes gastric inflammation, atrophy, and tumorigenesis in mice

Kaili Fu, Alvin H.K. Cheung, Chi Chun Wong, Weixin Liu et autres

Publisher of over 50 scientific journals across the life, physical, earth, and health sciences, both independently and in partnership with scientific societies including Cell, Neuron, Immunity, Current Biology, AJHG, and the Trends Journals.

Metagenomic Analysis Reveals Large‐Scale Disruptions of the Gut Microbiome in Parkinson's Disease

Avril Metcalfe‐Roach, Mihai Cîrstea, Adam C. Yu, Hena R. Ramay et autres

BACKGROUND: Parkinson's disease (PD) has been consistently linked to alterations within the gut microbiome. OBJECTIVE: Our goal was to identify microbial features associated with PD incidence and progression. METHODS: Metagenomic sequencing was used to characterize taxonomic and functional changes to the PD …

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Su1142 MULTI-COHORT ANALYSIS OF COLORECTAL CANCER FECAL METAGENOME IDENTIFIED ALTERED ARCHAEA ACROSS POPULATIONS AND UNIVERSAL ARCHAEAL MARKERS

Tianhui Li, Olabisi Oluwabukola Coker, Chuanfa Liu, Yufeng Lin et autres

Blood microbial signatures associated with mortality in patients with sepsis: A pilot study

Huarong Chen, Weixin Liu, Olabisi Oluwabukola Coker, Na Qin et autres

Sepsis is a life-threatening illness caused by the dysregulated host response to infection. Nevertheless, our current knowledge of the microbial landscape in the blood of septic patients is still limited. Next-generation sequencing (NGS) is a sensitive method to quantitatively characterize microbiomes at …

hk, cn, sg (code pays fourni par la source)

Streptococcus anginosus promotes gastric inflammation, atrophy, and tumorigenesis in mice

Kaili Fu, Alvin H.K. Cheung, Chi Chun Wong, Weixin Liu et autres

Streptococcus anginosus (S. anginosus) was enriched in the gastric mucosa of patients with gastric cancer (GC). Here, we show that S. anginosus colonized the mouse stomach and induced acute gastritis. S. anginosus infection spontaneously induced progressive chronic gastritis, parietal cell atrophy, mucinous …

hk, cn, sg (code pays fourni par la source)

PacBio sequencing of human fecal samples uncovers the DNA methylation landscape of 22 673 gut phages

Yanqiang Ding, Liuyang Zhao, Guoping Wang, Yu Shi et autres

Gut phages have an important impact on human health. Methylation plays key roles in DNA recognition, gene expression regulation and replication for phages. However, the DNA methylation landscape of gut phages is largely unknown. Here, with PacBio sequencing (2120×, 4785 Gb), we …

hk, cn (code pays fourni par la source)

IDDF2023-ABS-0053 PacBio sequencing reveals human enteric virus DNA methylation and its roles for viruses

Yanqiang Ding, Liuyang Zhao, Guoping Wang, Yu Shi et autres

Background Enteric viruses have an important impact on human health. Methylation plays a key role in DNA recognition and replication for viruses. However, the DNA methylation of enteric viruses is largely unknown. We aim to uncover human enteric virus DNA methylation based …

hk, cn (code pays fourni par la source)

Non-bacteria Microbiome (Virus, Fungi, and Archaea) in Gastrointestinal Cancer

Olabisi Oluwabukola Coker

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Altered gut microbiome composition by appendectomy contributes to colorectal cancer

Feiyu Shi, Gaixia Liu, Yufeng Lin, Cosmos Liutao Guo et autres

Appendectomy impacts the homeostasis of gut microbiome in patients. We aimed to study the role of appendectomy in colorectal cancer (CRC) risk through causing gut microbial dysbiosis. Population-based longitudinal study (cohort 1, n = 129,155) showed a 73.0% increase in CRC risk …

cn, hk (code pays fourni par la source)