Dag Linnarsson

European Space Agency Nitric Oxide - 1

Per Co-Investigator: Blom, M. Co-Investigator: Carlson, Claes Co-Investigator: Frostell, Lars Co-Investigator: Gustafsson et autres

Airway Nitric Oxide in Space

Lars Co-Investigator: Gustafsson, Dag Linnarsson, A Van Muylem, Lars L. Karlsson

European Space Agency Nitric Oxide - 2

Per Co-Investigator: Blom, M. Co-Investigator: Carlson, Claes Co-Investigator: Frostell, Lars Co-Investigator: Gustafsson et autres

Fluid-regulating hormones and plasma volume during 60 days of head-down bed rest with exercise during artificial gravity (BRACE)

Carol G. Bryans, Carmelo J. Mastrandrea, Eric T. Hedge, Christoph Siebenmann et autres

Artificial gravity (AG) combined with exercise was proposed to protect plasma volume during head-down bed rest (HDBR). Our results suggest that by performing exercise with simultaneous AG, the previously identified beneficial effect of gravity-like exposure after exercise during prolonged HDBR is lost. …

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Exercise during artificial gravity preserves cardiorespiratory fitness but not orthostatic tolerance following 60 days of head-down bed rest (BRACE)

Eric T. Hedge, Carol G. Bryans, Carmelo J. Mastrandrea, Christoph Siebenmann et autres

Exposing participants to artificial gravity (AG) while performing high-intensity interval cycling protects cardiorespiratory fitness after 60 days of head-down bed rest but not orthostatic tolerance. These effects are not different than performing exercise without AG. Accordingly, to gain the previously reported benefits …

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Potential pulmonary toxic effects of Martian dust simulant

Jie Ji, Jasmine Rita Petriglieri, Francesco Turci, Shanzina Iasmin Sompa et autres

Human exploration of the Moon and Mars will inevitably result in exposure to extraterrestrial dust. We investigated the potential pulmonary toxicity of JSC Mars-1(Martian dust simulant, respirable diameter 1.45 μm) using an advanced multicellular lung mucosa model with dust applied apically to …

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Pulmonary nitric oxide in astronauts before and during long-term spaceflight

Lars L. Karlsson, Lars E. Gustafsson, Dag Linnarsson

Introduction: During exploratory space flights astronauts risk exposure to toxic planetary dust. Exhaled nitric oxide partial pressure (PENO) is a simple method to monitor lung health by detecting airway inflammation after dust inhalation. The turnover of NO in the lungs is dependent …

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Lung diffusing capacity for nitric oxide in space: microgravity gas density interactions

Lars L. Karlsson, Alain Van Muylem, Dag Linnarsson

Introduction: During manned space exploration lung health is threatened by toxic planetary dust and radiation. Thus, tests such as lung diffusing capacity (DL) are likely be used in planetary habitats to monitor lung health. During a DL maneuver the rate of uptake …

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Potential toxic effects in the lung of planetary dust

J Ji, Ingrid Corazzari, F Turci, Per Gerde et autres

As space exploration extends to the Moon and Mars, both astronauts and workers in earth-based test facilities will be exposed to extraterrestrial dust. In this study, the ESA Topical Team on the Toxicity of Celestial Dust (T3CD) exposed lung mucosa models to …

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Evaluation of the Toxicity of Lunar Dust Exposed to Simulated Space Radiation: Perspective from an ESA Topical Team

Marco Durante, Bice Fubini, Per Gerde, Linnéa Karlsson et autres

Combined Effects of Microgravity and Reduced Gas Density on an Exhaled Biomarker for Airway Inflammation

Dag Linnarsson, Lars Karlsson

Towards human exploration of space: the THESEUS review series on cardiovascular, respiratory, and renal research priorities

ANDRE E. AUBERT, Irina V. Larina, Iman Momken, Stéphane Blanc et autres

The THESEUS project (Towards Human Exploration of Space: a EUropean Strategy) was initiated within the seventh Framework Programme by the European Commission. This project aimed to provide a cross-cutting, life science-based roadmap for Europe’s strategy towards human exploration of space, especially for …

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