Brendon Wong

Acceptable respondent burden in patient-reported outcome (PRO) assessment in oncology clinical trials: a mixed methods study with patients and trialists

Selin Yurdakul, Alexandros Georgiadis, Bert Sandy, Heiko Zettl et autres

BACKGROUND: Patient-reported outcomes (PROs) are essential for measuring the effectiveness of medical treatments from the patient’s perspective. PROs are typically defined as any measure that describes or reflects how a patient feels, functions, or survives, and are becoming increasingly important in regulatory …

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Validity, reliability, responsiveness, and clinically meaningful change threshold estimates of the National Comprehensive Cancer Network-Functional Assessment of Cancer Therapy-Breast Cancer Symptom Index (NFBSI-16)

Nathan A. Clarke, Brendon Wong, Rachael M Lawrance, Anders Ingelgård et autres

BACKGROUND: Breast cancer is one of the most common cancers in women. Patient-reported outcome measures are used to evaluate patients' health-related quality of life in clinical breast cancer studies. This study evaluated the structure, validity, reliability, and responsiveness of the National Comprehensive …

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Setting International Standards in Analyzing Patient-Reported Outcomes and Quality of Life Endpoints in Cancer Clinical Trials-Innovative Medicines Initiative (SISAQOL-IMI): stakeholder views, objectives, and procedures

Madeline Lee Pe, Ahu Alanya, Ragnhild Sørum Falk, Cecilie Delphin Amdal et autres

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A Mixed-Methods Study to Better Measure Patient-Reported Pain and Fatigue in Soft Tissue Sarcoma

Louise Barrett, Emma Elliott, Maarten Voorhaar, Anders Ingelgård et autres

INTRODUCTION: Pain and fatigue are commonly reported by patients with soft tissue sarcoma (STS) as distressing symptoms, yet no patient-reported outcome (PRO) measures have been validated or developed specifically for STS. This study aimed to develop novel PRO scales using existing item …

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Development of a disease conceptual model of patient experience with metastatic colorectal cancer: identification of the most salient symptoms and impacts

Isabelle Guillemin, Mahesh Darpelly, Brendon Wong, Anders Ingelgård et autres

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Development of a disease conceptual model of patient experience with metastatic colorectal cancer: identification of the most salient symptoms and impacts.

Isabelle Guillemin, Mahesh Darpelly, Brendon Wong, Anders Ingelgård et autres

Abstract Purpose. Patients with metastatic colorectal cancer (mCRC) experience multiple symptoms and impacts affecting their health-related quality of life. However, there is limited data on self-reported experience of the most relevant and bothersome aspects of patients living with mCRC.Methods. Semi-structured interviews were …

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Obstructive Sleep Apnea in Neuro-Ophthalmology

Brendon Wong, Clare L. Fraser

BACKGROUND: Obstructive sleep apnea (OSA) is a common pulmonary disorder with many systemic sequelae. Its association with diseases seen in neuro-ophthalmology is being increasingly recognized. Treatment of OSA with continuous positive airway pressure (CPAP) may reverse the pathology in some eye diseases. …

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