Sara Notararigo

The role of microbial succinate in the pathophysiology of inflammatory bowel disease: mechanisms and therapeutic potential

Sonia Fernández‐Veledo, Carme Grau‐Bové, Sara Notararigo, Isabel Huber‐Ruano

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Extracellular Vesicle Therapy for Type 1 Diabetes

Setareh Soltani, Kamran Mansouri, Mohammad Sajad Emami Aleagha, Narges Moasefi et autres

Type 1 diabetes (T1D) is a chronic disorder characterized by immune-mediated destruction of pancreatic insulin-producing β-cells. The primary treatment for T1D is multiple daily insulin injections to control blood sugar levels. Cell-free delivery packets with therapeutic properties, extracellular vesicles (EVs), mainly from …

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Anti-Inflammatory Effect of an O-2-Substituted (1-3)-β-D-Glucan Produced by Pediococcus parvulus 2.6 in a Caco-2 PMA-THP-1 Co-Culture Model

Sara Notararigo, Encarna Varela, Anna Otal, Maria Antolı́n et autres

Bacterial β-glucans are exopolysaccharides (EPSs), which can protect bacteria or cooperate in biofilm formation or in bacterial cell adhesion. Pediococcus parvulus 2.6 is a lactic acid bacterium that produces an O-2-substituted (1-3)-β-D-glucan. The structural similarity of this EPS to active compounds such …

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P047 Effect of infliximab and vedolizumab on M1 and M2 macrophages derived from THP-1 cells

Sara Notararigo, Juan E. Viñuela, M J Zurita-Gonzalez, Erika Medina et autres

Abstract Background Inflammatory bowel diseases encompass two pathologies affecting the digestive tract, Crohn’s disease (CD) and ulcerative colitis (UC). They are characterized by a high and chronic inflammatory rate, resulting from activation of the intestinal immune system and increased permeability of the …

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Targeted 1H NMR metabolomics and immunological phenotyping of human fresh blood and serum samples discriminate between healthy individuals and inflammatory bowel disease patients treated with anti-TNF

Sara Notararigo, Manuel Martín‐Pastor, Juan E. Viñuela, Adriano Quiroga et autres

Inflammatory bowel disease is a multifactorial etiology, associated with environmental factors that can trigger both debut and relapses. A high level of tumor necrosis factor-α in the gut is the main consequence of immune system imbalance. The aim of treatment is to …

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P078 Proteomics and Lipidomics Analysis Revealed Alterations of Complement Activation and Lipid Metabolism in peripheral blood mononuclear cells of Inflammatory Bowel Disease Patients

Sara Notararigo, Susana B. Bravo, Manuel Martín‐Pastor, Iria Bastón‐Rey et autres

Abstract Background The lack of interaction between immune system cells and microbiota is considered a key driver of the pathogenesis of inflammatory bowel disease (IBD). The association of age-associated B cells (ABC) from antigen-experienced B cells and autoimmunity is now well established. …

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Evaluation of an O2-Substituted (1–3)-β-D-Glucan, Produced by Pediococcus parvulus 2.6, in ex vivo Models of Crohn’s Disease

Sara Notararigo, Encarna Varela, Anna Otal, Iván Cristobo et autres

1,3-β-glucans are extracellular polysaccharides synthesized by microorganisms and plants, with therapeutic potential. Among them, the O2-substituted-(1–3)-β-D-glucan, synthesized by some lactic acid bacteria (LAB), has a prebiotic effect on probiotic strains, an immunomodulatory effect on monocyte-derived macrophages, and potentiates the ability of the …

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P052 Nuclear magnetic resonance metabolomic profiling of IBD patients under anti-TNF treatment. Are the pathways network deregulated?

Sara Notararigo, Manuel Martín‐Pastor, J. Enrique Domínguez‐Muñoz, Manuel Barreiro‐de Acosta

Abstract Background The deregulation of immune system cell response implies loss of T-cell apoptosis, high rate of proinflammatory cytokines production and subsequent exacerbate activation of TNF-α pathway. The use of biologic antibody decrease inflammation rate and symptoms, but it remains unclear if …

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P089 Immune system cell differences between Crohn’s disease and ulcerative colitis patients in remission under anti TNF treatment

Sara Notararigo, J E Viñuela Roldán, Adriano Quiroga, J. Enrique Domínguez‐Muñoz et autres

Abstract Background Inflammatory bowel disease (Crohn’s disease (CD) and ulcerative colitis (UC)) are chronic gastrointestinal disorders of unknown aetiology where the immune system dysregulation is the responsible for immunological imbalance characterised by a relevant production of pro-inflammatory cytokines. The tumour necrosis factor-α …

P062 Differences in immune cell population subsets in inflammatory bowel disease patients under anti-TNF treatment

Sara Notararigo, J E Viñuela Roldán, María Abanades Tercero, J. Enrique Domínguez‐Muñoz et autres

In autoimmune diseases targets attacked by the immune system differ one from another and the immune system deregulation seems to be the main cause of these pathologies. The aim of this study was to determine the existence of a differential pattern in …

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Estudio en modelos "In vitro" y "Ex vivo" de los efectos inmunomoduladores del (1-3)-β-D-glucano sustituido en posición O-2 producido por bacterias ácido lácticas

Sara Notararigo

Los (1,3)-b-D-glucanos sintetizados por plantas y hongos son inmunomoduladores y algunos de ellos se utilizan para la elaboración de alimentos funcionales. Los exopolisacáridos (EPS) sintetizados por bacterias ácido lácticas (BAL) son polímeros extensamente estudiados por su amplia aplicación industrial, incluyendo la industria …

Current and Future Applications of Bacterial Extracellular Polysaccharides

Adrián Pérez-Ramos, Montserrat Nachér-Vázquez, Sara Notararigo, Paloma López et autres

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