Accès ouvert
2026
article
OpenAlex
Amanda L. Phelps, Lin S. Eastaugh, James S. Findlay, Ruth V. Thom et autres
Effective disinfectants are a requirement for safe operation within Containment Level 4 (CL4) laboratories. High-containment processes often demand that disinfectants remain effective over prolonged periods of time. Four candidate quaternary ammonium-based disinfectants were tested at room temperature for activity against Ebola virus …
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2022
article
OpenAlex
Rachel E. Ireland, Carwyn D. Davies, Emma Keyser, James S. Findlay et autres
There is an enduring requirement to develop animal models of COVID-19 to assess the efficacy of vaccines and therapeutics that can be used to treat the disease in humans. In this study, six marmosets were exposed to a small particle aerosol (1-3 …
gb
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Accès ouvert
2021
erratum
OpenAlex
Ruth E. Thom, Lin S. Eastaugh, Lyn M. O’Brien, David Ulaeto et autres
In the original article, there was a mistake in Table 1; Protocols tested for assessing inactivation using lysis buffers as published. During the publication process the components for each of the three kits tested in this study (as stated in the 'Reagents' …
gb
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Accès ouvert
2021
article
OpenAlex
Ruth E. Thom, Lin S. Eastaugh, Lyn M. O’Brien, David Ulaeto et autres
Rapid and demonstrable inactivation of SARS-CoV-2 is crucial to ensure operator safety during high-throughput testing of clinical samples. The inactivation efficacy of SARS-CoV-2 was evaluated using commercially available lysis buffers from three viral RNA extraction kits used on two high-throughput (96-well) RNA …
gb
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Accès ouvert
2021
article
OpenAlex
Sophie J. Smither, Lin S. Eastaugh, James S. Findlay, Thomas R. Laws et autres
A small-scale study with Mosi-guard Natural spray, an insect repellent containing Citriodiol, was performed to determine if it has virucidal activity against SARS-CoV-2. A liquid test examined the activity of the insect repellent and the individual components for virucidal activity. A surface …
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Accès ouvert
2021
preprint
OpenAlex
Ruth E. Thom, Lin S. Eastaugh, Lyn M. O’Brien, David Ulaeto et autres
ABSTRACT Rapid and demonstrable inactivation of SARS-CoV-2 is crucial to ensure operator safety during high-throughput testing of clinical samples. The inactivation efficacy of SARS-CoV-2 was evaluated using commercially available lysis buffers from three viral RNA extraction kits used on two high-throughput (96-well) …
gb
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Accès ouvert
2020
article
OpenAlex
Sophie J. Smither, Lin S. Eastaugh, James S. Findlay, Lyn M. O’Brien et autres
Knowledge of the survival and stability of a pathogen is important for understanding its risk, reducing its transmission, and establishing control measures. Lassa virus is endemic in West Africa, causes severe disease, and is an emerging pathogen of concern. Our study examined …
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Accès ouvert
2020
article
OpenAlex
Sophie J. Smither, Isabel García-Dorival, Lin S. Eastaugh, James S. Findlay et autres
As the ongoing outbreak in the Democratic Republic of Congo illustrates, Ebola virus disease continues to pose a significant risk to humankind and this necessitates the continued development of therapeutic options. One option that warrants evaluation is that of defective genomes; these …
gb
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2020
article
OpenAlex
Sophie J. Smither, Lin S. Eastaugh, James S. Findlay, Mark S. Lever
SARS-CoV-2, the causative agent of the COVID-19 pandemic, may be transmitted via airborne droplets or contact with surfaces onto which droplets have deposited. In this study, the ability of SARS-CoV-2 to survive in the dark, at two different relative humidity values and …
gb
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Accès ouvert
2019
article
OpenAlex
James S. Findlay, Helen C. Flick-Smith, Emma Keyser, Ian A. M. Cooper et autres
With the rise of antimicrobial resistance, novel ways to treat bacterial infections are required and the use of predatory bacteria may be one such approach. Bdellovibrio species have been shown in vitro to predate on a wide range of other Gram-negative bacteria, …
gb
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Accès ouvert
2019
article
OpenAlex
Sophie J. Smither, Lin S. Eastaugh, James S. Findlay, Lyn M. O’Brien et autres
Nipah virus (NiV) infection is a newly emerging zoonosis that causes severe disease in humans. Nipah virus is one of the lesser studied of the WHO emerging pathogens for which research is a priority. Survival and persistence data is important for risk …
gb
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Accès ouvert
2018
article
OpenAlex
James S. Findlay, Graham P. Cook, G. Eric Blair
It has been proposed that blood coagulation factors, principally factor X (FX), enhance the uptake of human adenovirus type 5 (Ad5) into cultured epithelial cells by bridging the viral hexon capsid protein and cell-surface heparan sulphate proteoglycans (HSPGs). We studied the effects …
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