Olaf Schneewind

Lipoteichoic Acid Synthesis and Function in Gram-Positive Bacteria

Amany M. Ibrahim, Olaf Schneewind, Dominique M. Missiakas

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Inhibitory activities of monoclonal antibodies against Staphylococcus aureus clumping factor A

B. N. Banerjee, Carla Emolo, Miaomiao Shi, Abrar Abdullah Al Fardan et autres

ABSTRACT Staphylococcus aureus infection is a frequent cause of sepsis in humans, a disease associated with high mortality and without specific intervention. Clumping factor A (ClfA) displayed on the bacterial surface plays a key role in promoting S. aureus replication during invasive …

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Inhibitory activities of monoclonal antibodies against Staphylococcus aureus Clumping factor A

B. N. Banerjee, Carla Emolo, Miaomiao Shi, Abrar Abdullah Al Fardan et autres

ABSTRACT Staphylococcus aureus infection is a frequent cause of sepsis in humans, a disease associated with high mortality and without specific intervention. Clumping factor A (ClfA) displayed on the bacterial surface plays a key role in promoting S. aureus replication during invasive …

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A SecA-associated protease modulates the extent of surface display of staphylococcal protein A

Muhammad S. Azam, Amany Mohamed Ibrahim, Owen K. Leddy, So‐Young Oh et autres

ABSTRACT In bacteria, signal peptides direct pre-proteins to the SecYEG secretion channel and are typically cleaved by signal peptidases during translocation across the membrane. In gram-positive bacteria, such as Staphylococcus aureus , some signal peptides have a pre-translocation function. Staphylococcal protein A …

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Screening a library of temperature-sensitive mutants to identify secretion factors in Staphylococcus aureus

Owen K. Leddy, Amany Mohamed Ibrahim, Muhammad S. Azam, Sadie Solomon et autres

ABSTRACT Protein secretion is an essential cell process in bacteria, required for cell envelope biogenesis, export of virulence factors, and acquisition of nutrients, among other important functions. In the Sec secretion pathway, signal peptide-bearing precursors are recognized by the SecA ATPase and …

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Deficiency in non-classical major histocompatibility class II-like molecule, H2-O confers protection against Staphylococcus aureus in mice

Emily Cullum, Yunys Pérez-Betancourt, Miaomiao Shi, Eirinaios Gkika et autres

Staphylococcus aureus is a human-adapted pathogen that replicates by asymptomatically colonizing its host. S. aureus is also the causative agent of purulent skin and soft tissue infections as well as bloodstream infections that result in the metastatic seeding of abscess lesions in …

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Processing of LtaS restricts LTA assembly and YSIRK preprotein trafficking into Staphylococcus aureus cross-walls

Amany Mohamed Ibrahim, Muhammad S. Azam, Olaf Schneewind, Dominique M. Missiakas

In Staphylococcus aureus , peptidoglycan is assembled at the septum. Dedicated cell division proteins coordinate septal formation and the fission of daughter cells. Lipoteichoic acid (LTA) assembly and trafficking of preproteins with a YSIRK motif also occur at the septum. This begs …

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Processing of LtaS restricts LTA assembly and YSIRK preprotein trafficking into Staphylococcus aureus cross-walls

Amany M. Ibrahim, Muhammad S. Azam, Olaf Schneewind, Dominique M. Missiakas

Septal membranes of Staphylococcus aureus serve as the site of secretion for precursors endowed with the YSIRK motif. Depletion of ltaS, a gene required for lipoteichoic acid (LTA) synthesis, results in the loss of restricted trafficking of YSIRK precursors to septal membranes. …

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Processing of LtaS restricts LTA assembly and YSIRK preprotein trafficking into Staphylococcus aureus cross-walls

Amany M. Ibrahim, Muhammad S. Azam, Olaf Schneewind, Dominique M. Missiakas

Septal membranes of Staphylococcus aureus serve as the site of secretion for precursors endowed with the YSIRK motif. Depletion of ltaS, a gene required for lipoteichoic acid (LTA) synthesis, results in the loss of restricted trafficking of YSIRK precursors to septal membranes. …

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Immunoglobulin G subclasses confer protection against Staphylococcus aureus bloodstream dissemination through distinct mechanisms in mouse models

Xinhai Chen, Haley Gula, Tonu Pius, Chong Ou et autres

Antibodies bind target molecules with exquisite specificity. The removal of these targets is mediated by the effector functions of antibodies. We reported earlier that the monoclonal antibody (mAb) 3F6 promotes opsonophagocytic killing of Staphylococcus aureus in blood and reduces bacterial replication in …

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Immunoglobulin G subclasses confer protection against Staphylococcus aureus bloodstream dissemination through distinct mechanisms in mouse models

Xinhai Chen, Haley Gula, Tonu Pius, Chong Ou et autres

Antibodies bind target molecules with exquisite specificity. The removal of these targets is mediated by the effector functions of antibodies. We reported earlier that the monoclonal antibody (mAb) 3F6 promotes opsonophagocytic killing of Staphylococcus aureus in blood and reduces bacterial replication in …

us (code pays fourni par la source)

Immunoglobulin G subclasses confer protection against Staphylococcus aureus bloodstream dissemination through distinct mechanisms in mouse models

Xinhai Chen, Haley Gula, Tonu Pius, Chong Ou et autres

Antibodies bind target molecules with exquisite specificity. The removal of these targets is mediated by the effector functions of antibodies. We reported earlier that the monoclonal antibody (mAb) 3F6 promotes opsonophagocytic killing of Staphylococcus aureus in blood and reduces bacterial replication in …

us (code pays fourni par la source)